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公开(公告)号：EP0764849A1
公开(公告)日：1997-03-26
申请号：EP96401973.1
申请日：1996-09-17
发明人： Mizon, Jacques , Burnouf, Thierry
IPC分类号： G01N33/573 , C07K16/38
CPC分类号： C07K16/38 , G01N33/573
摘要： L'invention concerne un test immunologique pour la détection et le dosage spécifiques de l'ITI ainsi que les immunoglobulines spécifiques des chaînes lourdes H 1 et H 2 de l'ITI qui permettent de piéger celui-ci "en sandwich" et qui rendent ledit test possible et hautement spécifique. L'invention trouve des applications dans le domaine diagnostic et dans l'analyse fine du métabolisme de l'ITI.
摘要翻译： 用于α间 - 胰蛋白酶抑制剂（ITI）的三明治免疫测定使用：（a）对ITI的2个重链中的1个特异性并固定在载体上的免疫球蛋白，和（b）对另一个特异性的免疫球蛋白 重链ITI并用生物素标记。 还要求的是：（1）特异于ITI重链H1的免疫球蛋白。 通过免疫具有高纯度H1制剂的动物，回收粗制抗血清并通过消除污染性免疫球蛋白来纯化抗H1免疫球蛋白。 抗H2和抗bikunin免疫球蛋白，通过吸附在制剂上。 的固定在CNBr活化的“琼脂糖凝胶”（RTM）上的H2和比肯宁，和（2）对ITI重链H2的特异性免疫球蛋白。 通过免疫具有高纯度H2制剂的动物，回收粗制抗血清并通过消除污染性免疫球蛋白来纯化抗-H2免疫球蛋白， 抗H1免疫球蛋白，通过吸附在制剂上。 的H1固定在CNBr活化的“Sepharose”（RTM）上。
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公开(公告)号：EP0669344A3
公开(公告)日：1996-12-18
申请号：EP95102569.1
申请日：1995-02-23
发明人： Yago, Hirokazu, C/o Daiichi Pure Chemicals , Hanada, Hisashi, C/o Daiichi Pure Chemicals , Wada, Masato, c/o Daiichi Pure Chemicals , Ushizawa, Koji, c/o Daiichi Pure Chemicals
摘要： Monoclonal antibodies which exhbit specificity anti-thrombin-antithrombin III complexes and a method for imunologically measuring the anti-thrombin-antithrombin III complexes. Because the monoclonal antibodies of the present invention specifically recognize and exhibit high affinity with thrombin-antithrombin III complexes, they can accurately determine concentrations of thrombin-antithrombin III complexes in samples without being affected by cross-reaction products and is thus useful for diagnosis of a blood clotting tendency.
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33.发明公开Monoclonal antibody and immunoassay using the same 失效MonokeparerAntikörperund seine Verwendung in einem Immunoassay。
公开(公告)号：EP0669344A2
公开(公告)日：1995-08-30
申请号：EP95102569.1
申请日：1995-02-23
发明人： Yago, Hirokazu, C/o Daiichi Pure Chemicals , Hanada, Hisashi, C/o Daiichi Pure Chemicals , Wada, Masato, c/o Daiichi Pure Chemicals , Ushizawa, Koji, c/o Daiichi Pure Chemicals
摘要： Monoclonal antibodies which exhbit specificity anti-thrombin-antithrombin III complexes and a method for imunologically measuring the anti-thrombin-antithrombin III complexes. Because the monoclonal antibodies of the present invention specifically recognize and exhibit high affinity with thrombin-antithrombin III complexes, they can accurately determine concentrations of thrombin-antithrombin III complexes in samples without being affected by cross-reaction products and is thus useful for diagnosis of a blood clotting tendency.
摘要翻译： 特异性抗凝血酶 - 抗凝血酶III复合物的单克隆抗体和用于免疫测定抗凝血酶 - 抗凝血酶III复合物的方法。 由于本发明的单克隆抗体特异性地识别并表现出与凝血酶 - 抗凝血酶III复合物的高亲和力，因此它们可以准确地测定样品中凝血酶 - 抗凝血酶III复合物的浓度，而不受交叉反应产物的影响，因此可用于诊断 血液凝固倾向。
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34.发明公开ANTIBODY AGAINST HUMAN PLASMIN--G(A) 2?-PLASMIN INHIBITOR COMPLEX, HYBRIDOMA AND IMMUNOASSAY 失效抗人体抗体 - G（A）2？血小板抑制剂复合物，杂交和免疫调节
公开(公告)号：EP0516863A4
公开(公告)日：1993-06-09
申请号：EP92901440
申请日：1991-12-19
IPC分类号： C07K16/38 , C07K16/40 , C12N5/20 , C12P21/08 , G01N33/577
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35.发明公开Antibody to a mediator activity composition and its use in a pharmaceutical composition. 无效抗体调解活动组合物及其在药物组合物的使用。
公开(公告)号：EP0101681A4
公开(公告)日：1985-06-06
申请号：EP82902957
申请日：1982-09-08
申请人： UNIV ROCKEFELLER
发明人： CERAMI ANTHONY , KAWAKAMI MASANOBU
IPC分类号： C12N15/02 , A61K31/00 , A61K35/24 , A61K38/00 , A61K38/55 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/04 , A61P9/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/38 , C07K16/42 , C12N5/0789 , C12P1/00 , C12P21/08 , C12Q1/00 , G01N33/53 , G01N33/569
CPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4703 , C07K14/523 , C07K16/18 , C07K16/24 , C07K16/241 , C07K16/38 , C07K16/4241 , C12N5/0647 , C12N2501/21 , C12N2501/22 , C12P1/00 , C12R1/91 , G01N33/5308 , G01N33/569 , G01N33/56905 , G01N2333/52 , G01N2400/40
摘要： Mediator substances exhibiting inhibitory effect upon anabolic enzyme activity in mammals, are prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and incubating the macrophage cells to produce the mediator substance. The stimulator materials, for example, may include endotoxins, trypanosomes and the like, and the enzymes that may be observed range from lipoprotein lipase, acetyl Coenzyme A carboxylase and fatty acid synthetase, to the inducers for red blood cells growth and differentiation. The mediator substance may be utilized to raise antibodies which would in turn find utility in testing for the presence or amount of various invasive stimuli, such as infection and the like. Testing procedures and appropriate materials in kit form are also contemplated. The mediator substances may likewise be utilized in procedures as screening agents, to test for potentially effective antishock agents or chemicals.
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公开(公告)号：EP4177267A1
公开(公告)日：2023-05-10
申请号：EP22202435.8
申请日：2016-01-27
发明人： HOROWITZ, Lawrence
IPC分类号： C07K16/18 , C07K16/28 , C07K16/38 , G01N33/574 , G01N33/569 , C07K16/42 , G01N33/564
摘要： The present invention concerns anti-surrogate light chain antibodies and their uses. In particular, the present invention concerns anti-VpreBI antibodies and their uses.
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公开(公告)号：EP4058061A1
公开(公告)日：2022-09-21
申请号：EP20821374.4
申请日：2020-11-10
申请人： Pfizer Inc.
IPC分类号： A61K39/395 , C07K16/38
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38.发明授权
公开(公告)号：EP2970499B1
公开(公告)日：2022-08-10
申请号：EP14710541.5
申请日：2014-03-14
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公开(公告)号：EP3194447B1
公开(公告)日：2021-12-01
申请号：EP15763621.8
申请日：2015-09-17
发明人： PETERSEN, Helle Heibroch , KROGH, Berit Olsen , BREINHOLT, Jens , KOFOD-HANSEN, Mikael , HILDEN, Ida
IPC分类号： C07K16/38 , C07K16/46 , A61K39/395
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公开(公告)号：EP3102610B1
公开(公告)日：2020-01-22
申请号：EP15706386.8
申请日：2015-02-09
申请人： Katholieke Universiteit Leuven , INSERM - Institut National de la Santé et de la Recherche Médicale , Université de Caen Basse Normandie , Centre Hospitalier Universitaire de Caen
发明人： DECLERCK, Paul , DE MEYER, Simon , GEUKENS, Nick , GILS, Ann , RUBIO, Marina , VIVIEN, Denis , WYSEURE, Tine
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