公开(公告)号：EP1097613B1

公开(公告)日：2003-03-05

申请号：EP98911249.5

申请日：1998-03-27

申请人： Hwang, Gapwoo

发明人： Hwang, Gapwoo

IPC分类号： H05B41/36

CPC分类号： H05B41/2885 ,  Y02B20/202 ,  Y10S315/07

摘要： Disclosed is an electronic ballast for a high intensity discharge lamp which is capable of reducing the number of parts to thereby maintain a high power factor and prevent power loss generated in the circuit thereof. The electronic ballast includes: a converter part (2) having first to fourth rectifying diodes (D1-D4), a choke coil (TR2) and a first condenser (C4); an inverter part (3) having first and second switching transistors (K1, K2), a second condenser (C13), a DIAC (D11), and first and second gate wave shaping integrated circuits (IC1, IC2); an output matching part (4) having a resonant coil (TR4), first to third resonant condensers (C7-C9), and a transformer (TR3); an absorbed DC power source part (5) having first and second diodes (D7, D8) and third and fourth condensers (C5,C6); a power control part (6) having a first operational amplifier (U2), first and second DC voltage detection resistors (R8, R9), a first resistor (R15), a second operational amplifier (U1), a second resistor (R7), a third resistor (R6), a first comparator (U3), a fourth resistor (R11), a second comparator (U4), a fifth resistor (R14), a first switch (SW1), a third comparator (U5), a timer, a sixth resistor (R16), a fifth condenser (C15) and an undervoltage lockout; and a gate transformer (TR5).

公开(公告)号：EP1272457A2

公开(公告)日：2003-01-08

申请号：EP01921087.1

申请日：2001-04-12

申请人： HSC Research and Development Limited Partnership

发明人： ROIFMAN, Chaim, M. ,  GRUNBERGER, Thomas ,  ROUNOVA, Olga ,  DEMIN, Peter ,  SHARFE, Nigel

IPC分类号： C07C255/34 ,  C07C255/40 ,  C07C255/41 ,  C07C255/42 ,  A61K31/165

CPC分类号： C07F7/1852 ,  C07C45/292 ,  C07C255/41 ,  C07C255/42 ,  C07C327/44 ,  Y02P20/582 ,  C07C47/277

摘要： Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).

公开(公告)号：EP1264832A1

公开(公告)日：2002-12-11

申请号：EP02008181.6

申请日：1998-04-15

申请人： Glycodesign Inc.

发明人： Dennis, James W. ,  Ziser, Lothar ,  Shah, Rajan N.

IPC分类号： C07D471/04 ,  A61K31/435

CPC分类号： C07D471/04 ,  A61K31/437

摘要： Crystalline salts of swainsonine, and methods of using the same. Pharmaceutical composition for treatment of cancer, hepatitis c, viral bacterial, fungal or parasitic infections; for stimulation hematopoietic growth, for inhibiting metasis or neoplastic growth, for stimulating the immune system, etc.

摘要翻译： 磺胺的结晶盐及其使用方法。 用于治疗癌症，丙型肝炎，病毒性细菌，真菌或寄生虫感染的药物组合物; 用于刺激造血生长，用于抑制肿瘤生长或肿瘤生长，刺激免疫系统等。

公开(公告)号：EP1241479A2

公开(公告)日：2002-09-18

申请号：EP01106463.1

申请日：2001-03-23

申请人： Immundiagnostik AG ,  ABC Armbruster Biochemicals

发明人： Armbruster, Franz, Paul ,  Stangl, Karl ,  Dschietzig, Thomas ,  Voelter, Wolfgang ,  Heller, Jörg

IPC分类号： G01N33/74 ,  G01N33/543

CPC分类号： G01N33/74 ,  G01N33/6893 ,  G01N2333/5751 ,  G01N2800/32

摘要： Method of determining the biological active urotensin II in a sample of a body fluid, comprising contacting the sample with polyclonal and/or monoclonal antibodies which have been elicted by immunisation with a cyclic peptide having the sequence: having a disulfide bridge formed between Cys 5 and Cys 10, and comprising the artificial sequence βAla-Cys, optionally conjugated with a carrier peptide. The obtained antibodies are then either purified or characterised by their binding to cyclic human urotensin II and can be used in a binding assay for a diagnosis of cardiovascular diseases, heptarenal syndrome, cirrhosis, diseases involving haemodynamic alterations, pathological conditions involving vasocontrictive substances.

摘要翻译： 确定性采矿生物活性尾加压素II的体液的样品中，其包括使用多克隆和/或单克隆抗体的样品哪个havebeen通过免疫与具有下面序列的环肽elicted的方法：具有二硫桥之间形成 的Cys <5>和Cys <10>和包含人工序列的β丙氨酸 - 半胱氨酸，任选地与载体肽缀合。 所获得的抗体然后纯化的或由它们的结合，以环状人类尾加压素II，并且可以在结合测定可用于心血管疾病，综合征heptarenal，肝硬化，疾病涉及的血液动力学改变，病理状况涉及vasocontrictive物质的诊断特征的。

公开(公告)号：EP0942795B1

公开(公告)日：2002-06-05

申请号：EP96922708.1

申请日：1996-07-18

申请人： Sherwood, William Lyon

发明人： Sherwood, William Lyon

IPC分类号： B22D11/06

摘要： A casting wheel is provided carrying a rotating inner-radius mold wall (8) along its rim and featuring a non-rotating mold sector (11) comprising at least one rigid mold segment (10) incorporating an outer-radius mold wall (12), circumferentially oscillated about an external stationary support (34). The casting wheel includes circumferential guide tracks (5, 6) around the wheel periphery, along which cam guide rollers (15) carrying the non-rotating segments (10) act to maintain a closely controlled interface clearance between the inner (9) and outer-radius (21) mold wall edges throughout the rotation. The non-rotating mold sector (11) may be constructed as a single enclosure, or multiple segments (10) hinged together for oscillation by a single oscillator (32), each segment incorporating its own guide roller system. Each box inside wall doubles as the mold envelope outside wall (12) which may be cooled by water sprays (39) directed from nozzles (38) or direct sealing and pressurizing of segments (10) through which controlled coolant flow is maintained. Because of the rigid construction of both wheel and closure, the invention is also adaptable to casting of wide slab sections for flat-rolled products, simply by increasing the width of the wheel in relation to the depth of the mold envelope. The invention includes embodiments providing adjustable-width side dams (44) for adjusting cast slab width, extra clearance for submerged entry nozzles for casting of thin slab sections, and is adaptable for a variety of near net shape products including structural sections. An embodiment includes non-oscillated roller segments (90) carrying a series of idler rollers (69) in place of the outer-radius mold wall (12), following the formation of a cohesive solid skin on the section being cast. This eliminates significant closure friction and assures non-sliding contact at controlled pressure between stock and wheel, thereby propelling the stock by static friction along the arc of contact with the wheel , rather than by pulling with withdrawal rollers following discharge, or with driven rollers along the containment section. Various other features and advantages of the apparatus are disclosed.

公开(公告)号：EP0758452B1

公开(公告)日：2001-11-07

申请号：EP95917877.3

申请日：1995-05-04

申请人： MOUNT SINAI HOSPITAL CORPORATION

发明人： DENNIS, James, W. ,  DEMETRIOU, Michael

IPC分类号： G01N33/50 ,  G01N33/68 ,  A61K38/17

CPC分类号： G01N33/6863 ,  A61K38/1793 ,  G01N33/74 ,  G01N2333/495 ,  G01N2500/00 ,  G01N2500/20 ,  Y10S514/885

摘要： The invention relates to a method for assaying for the presence of a substance that modulates a cytokine of the TGF- beta superfamily. A substance which is suspected of modulating a cytokine of the TGF- beta superfamily and a TGF- beta binding compound which is not a TGF- beta receptor and which contains a TRH1 domain, or a portion or mimetic thereof, is reacted with a cytokine of the TGF- beta superfamily under conditions where the compound, portion or mimetic thereof, and the cytokine are capable of forming a complex. Complexes, free compound and/or cytokine are assayed and compared with a control. The invention also relates to a composition comprising at least one compound which is not a TGF- beta receptor and which contains the TRH1 domain or a portion, or a mimetic thereof, and a pharmaceutically acceptable carrier, auxiliary or excipient and to methods of treatment using the composition. Further the invention relates to a method of enhancing the activity of growth factors.

公开(公告)号：EP1092437A1

公开(公告)日：2001-04-18

申请号：EP00123426.9

申请日：1996-05-09

申请人： UNIVERSITY TECHNOLOGIES INTERNATIONAL INC.

发明人： Buret, Andre G. ,  Hardin, James A. ,  Gall, Grant D. ,  Olson, Merle E.

IPC分类号： A61K38/18 ,  A23K1/16 ,  A61P1/04

CPC分类号： A61K31/277 ,  A23K20/147 ,  A23K20/168 ,  A23K50/00 ,  A23K50/30 ,  A61K38/1808

摘要： The use of epidermal growth factor for a manufacture of a medicament for treating or preventing gastric ulcers in an animal susceptible to or suffering from such ulcers is described. Epidermal growth factor (EGF) can be used as a gastrointestinal therapeutic agent. As such, EGF is useful in preventing gastrointestinal colonization by pathogens such as Helicobacter pylori . An important use of EGF is therefore in the prevention of bacterial colonization at gastric ulcer sites which contributes to the chronicity of the ulcer. EGF can also be used in accelerating the healing of gastric ulcers.

摘要翻译： 描述了使用表皮生长因子制造用于治疗或预防易患或患有这种溃疡的动物的胃溃疡的药物。 表皮生长因子（EGF）可用作胃肠道治疗剂。 因此，EGF可用于预防幽门螺杆菌等病原体的胃肠定植。 因此，EGF的重要用途是预防胃溃疡部位的细菌定植，这有助于溃疡的慢性。 EGF也可用于加速胃溃疡愈合。

公开(公告)号：EP1027264A1

公开(公告)日：2000-08-16

申请号：EP98949218.6

申请日：1998-10-13

申请人： Carmel, Avi ,  Liberman, Amir ,  Lev Ari, Amit

发明人： Carmel, Avi ,  Liberman, Amir ,  Lev Ari, Amit

IPC分类号： B65D79/02

CPC分类号： B65D79/02

摘要： The present invention relates to a milk product package useful for indicating milk acidity. This container is comprised of any (standard type of) milk product container, a transparent (impermeable) window (4) integrated into any side of the container (where the interior side of the window is in contact with the milk product and the exterior side of the window may be observed without opening the container), and a color changing acidity indicator located on the interior side of the window.

公开(公告)号：EP1007697A2

公开(公告)日：2000-06-14

申请号：EP98940016.3

申请日：1998-08-21

申请人： UNIVERSITY OF GUELPH

发明人： ETCHES, Robert J.,University of Guelph ,  MOHAMMED, Mansoor,University of Guelph ,  MORRISON, Sherie ,  WIMS, Letitia, Alice ,  TRINH, Kham, M. ,  WILDEMAN, Alan, G.

IPC分类号： C12N15/62 ,  C12N15/13 ,  C07K16/02 ,  C12N5/10 ,  A01K67/027

CPC分类号： C07K16/02 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/30 ,  A01K2267/01 ,  A61K48/00 ,  C12N15/8509

摘要： Methods for preparing recombinant proteins, such as antibodies, in eggs are described. The method offers advantages over existing systems for preparing recombinant proteins including high yield, low cost and compatibility with animal protection regulations. In addition, since eggs are edible food sources the recombinant protein does not have to be isolated from the egg.

公开(公告)号：EP1007095A2

公开(公告)日：2000-06-14

申请号：EP97925249.1

申请日：1997-06-04

申请人： YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： YARKONI, Shai ,  NECHUSHTAN, Amotz ,  LORBERBOUM-GALSKI, Haya ,  MARIANOVSKI, Irina

IPC分类号： A61K47/48

CPC分类号： A61K47/549

摘要： The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine lyomyoma cells, extra uterian endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.

摘要翻译： 本发明特别涉及靶向嵌合毒素的肿瘤细胞，其包含细胞靶向部分和细胞杀伤部分以识别和破坏肿瘤细胞，其中细胞靶向部分由促性腺激素释放激素同系物组成，细胞杀伤部分由假单胞菌外毒素A 本发明进一步涉及含有这些靶向嵌合毒素的肿瘤细胞作为活性成分的药物组合物以及制备这些嵌合毒素的方法。 所述发明还涉及用于治疗恶性癌细胞和良性增生（包括子宫肌瘤细胞，子宫外子宫内膜岛细胞，前列腺良性增生以及乳房和垂体肿瘤腺瘤细胞）的方法，其通过使用上述 嵌合毒素。