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    BIOFILM INCUBATION
    3.
    发明授权
    BIOFILM INCUBATION 失效
    生物膜的孵化

    公开(公告)号：EP0904347B1

    公开(公告)日：2005-08-03

    申请号：EP97906060.5

    申请日：1997-03-12

    申请人： UNIVERSITY TECHNOLOGIES INTERNATIONAL INC.

    发明人： CERI, Howard ,  OLSON, Merle, Edwin ,  MORCK, Douglas, Walter ,  READ, Ronald, Rae ,  BURET, Andre, Gerald

    IPC分类号： C12M1/14

    CPC分类号： B01L3/50853 ,  C12M23/38 ,  C12M25/06 ,  C12M27/16 ,  C12M35/04 ,  C12N9/20

    摘要： Biofilm forming organisms are incubated to form a biofilm on projections by providing a flow of liquid growth medium across projections, the direction of the flow of liquid being repeatedly changed, and an assay made of the resulting biofilm. Biofilm forming organisms are incubated to form a biofilm on projections arranged in rows, with several projections in each row, while providing a flow of liquid growth medium across each row of projections, and an assay made of the resulting biofilm. Sensitivity of the biofilm to antimicrobial reagent may be determined by treating the projections with antimicrobial reagent before carrying out the assay, by treating each row of projections with a different antimicrobial reagent, and each of the projections in a row with a different concentration of antibacterial reagent. A biofilm assay device includes a vessel including at least one channel for flow of liquid growth medium, projections arranged in at least one row and having a support for supporting the projections within the channel, and a tilt table to flow liquid growth medium along each channel in different directions across the projections. A further biofilm assay device includes a vessel including channels for flow of liquid growth medium, projections arranged in rows and having a support for supporting the projections within the channels, and a rocking table to rock the vessel and flow liquid growth medium along each channel across the projections.

    The use of epidermal growth factor (EGF) for increasing weight gain in an animal
    4.
    发明公开
    The use of epidermal growth factor (EGF) for increasing weight gain in an animal 失效
    Verwendung des epidermalen Wachstumsfaktors zur Steigerung der Gewichtszunahme beim Tier

    公开(公告)号：EP1479394A1

    公开(公告)日：2004-11-24

    申请号：EP04019831.9

    申请日：1996-05-09

    申请人： UNIVERSITY TECHNOLOGIES INTERNATIONAL INC.

    发明人： Buret, Andre G. ,  Gall, D. Grant ,  Hardin, James A. ,  Olson, Merle E.

    IPC分类号： A61K38/18 ,  A23K1/16 ,  A61P3/04

    CPC分类号： A61K31/277 ,  A23K20/147 ,  A23K20/168 ,  A23K50/00 ,  A23K50/30 ,  A61K38/1808

    摘要： A new use of epidermal growth factor (EGF) for preparing an agent for increasing weight gain in an animal is described. The agent is preferably formulated as a food additive or drinking water additive and administered in the feed of the animal. Another use of EGF is for preparing a medicament for treating malnourished people and persons suffering from anorexia nervosa. As such EGF can be used to increase animal production, for example in the agriculture or aquaculture industry.

    摘要翻译： 描述了用于制备增加动物体重增加剂的表皮生长因子（EGF）的新用途。 该试剂优选配制成食品添加剂或饮用水添加剂并在动物的饲料中施用。 EGF的另一用途是制备治疗营养不良的人和患有神经性厌食症的人的药物。 因此，EGF可用于增加动物生产，例如在农业或水产养殖业。

    LINKER PHOSPHORAMIDITES FOR OLIGONUCLEOTIDE SYNTHESIS
    6.
    发明公开
    LINKER PHOSPHORAMIDITES FOR OLIGONUCLEOTIDE SYNTHESIS 审中-公开
    LEFT亚磷酰胺用于生产寡核苷酸

    公开(公告)号：EP1319013A2

    公开(公告)日：2003-06-18

    申请号：EP01971543.2

    申请日：2001-09-10

    申请人： University Technologies International Inc.

    发明人： PON, Richard, T. ,  YU, Shuyuan

    IPC分类号： C07H21/00 ,  C07H19/06 ,  C07H19/16

    CPC分类号： C07H19/10 ,  C07B2200/11 ,  C07H19/00 ,  C07H19/20 ,  C07H21/00 ,  C40B40/00

    摘要： A novel approach for combining the ease of cleavage of carboxylic acid linker arms with the single phosphoramidite coupling chemistry of the universal supports useful in oligonucleotide synthesis. There is disclosed a new class of phosphoramidite reagents, linker phosphoramidites, which contain a bifunctional linker arm with a protected nucleoside linked through a 3'-ester bond on one end and a reactive phosphoramidite group or other phosphate precursor group on the other end. The phosphoramidite group on the linker phosphoramidite may be activated under the same conditions and has similar reactivity as conventional nucleoside-3'-phosphoramidite reagents lacking the intermediate linker arm. The 3'-ester linkage contained within the linker phosphoramidite has similar properties to the linkages on prederivatized supports. The ester linkage is stable to all subsequent synthesis steps, but upon treatment with a cleavage reagent, such as ammonium hydroxide, the ester linkage is hydrolyzed. This releases the oligonucleotide product with the desired 3'-hydroxyl terminus and leaves the phosphate portion of the reagent attached to the support, which is subsequently discarded.

    REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF
    8.
    发明公开
    REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF 失效
    可重复使用FESTTÄGER寡核苷酸合成，制造及其方法及其使用方法

    公开(公告)号：EP0876390A1

    公开(公告)日：1998-11-11

    申请号：EP96940964.0

    申请日：1996-12-13

    申请人： UNIVERSITY TECHNOLOGIES INTERNATIONAL INC.

    发明人： PON, Richard, T. ,  YU, Shuyuan

    IPC分类号： C07B61 ,  C07H19 ,  C07H21 ,  G01N33 ,  G01N37

    CPC分类号： C07H21/00 ,  C07B2200/11 ,  C07H19/06

    摘要： A solid support for oligonucleotide synthesis is disclosed. The solid support has formula (1) wherein: R8 is selected from the group consisting of a substituted or unsubstituted C¿1?-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; X?3 and X4¿ are the same or different and are selected from the group consisting of -O-, -S-, -S(O)¿2?- and -N(R?12)-; R12¿ is selected from the group consisting of a substituted or unsubstituted C¿1?-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; and Y is selected from the group consisting of: -CH2-CH2-; -CH2-; -CH2-O-CH2-; -CH2-CH2-CH2-; -CH=CH-; -CH=C(CH3)-; -C(CH3)=C(CH3)-; -CH2-C(=CH2)-; and -CH2-S-CH2-; wherein when Y is -CH2-CH2-, at least one of X?3 and X4¿ is -O-. An aspect of the invention also relates to a linker arm for oligonucleotide synthesis based on the solid support. Process for producing of the solid support and the linker arm, respectively, are also disclosed. The linker arm is characterized by being reusable in an otherwise conventional oligonucleotide production protocol.

    PHOTOCATALYST COMPOUND AND PROCESS FOR PRODUCTION THEREOF
    9.
    发明公开
    PHOTOCATALYST COMPOUND AND PROCESS FOR PRODUCTION THEREOF 失效
    光催化及其制备方法

    公开(公告)号：EP0812301A1

    公开(公告)日：1997-12-17

    申请号：EP96903847.0

    申请日：1996-03-04

    申请人： UNIVERSITY TECHNOLOGIES INTERNATIONAL INC.

    发明人： LANGFORD, Cooper, H. ,  XU, Yiming

    IPC分类号： B01J21 ,  B01J23 ,  B01J29 ,  B01J35 ,  C02F1

    CPC分类号： C02F1/32 ,  B01J35/002 ,  B01J35/004

    摘要： A photocatalyst compound comprising: (i) a photocatalyst selected from the group consisting of TiO2, WO3 and mixtures thereof, the photocatalyst being substantially free of sharp, narrow band X-ray reflections at angles corresponding to those of crystalline TiO2, WO3 and mixtures thereof, and (ii) a porous, crystalline, adsorbent support material. A process for producing the photocatalyst compound is also disclosed. The process comprises: (i) hydrolysing a non-ionic titanium compound to produce a colloidal suspension having an average particle size of less than about 250 Å; (ii) contacting a porous, crystalline, adsorbent support material with the colloidal suspension to produce an impregnated support; and (iii) calcining the impregnated support to produce the photocatalyst compound. The photocatalyst compound is useful, inter alia, in the treatment of a fluid containing an organic pollutant.