公开(公告)号：EP1432701A1

公开(公告)日：2004-06-30

申请号：EP02782863.1

申请日：2002-10-07

申请人： RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY ,  RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.

发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  RIVA, Carlo ,  TESTA, Rodolfo ,  CORBETT, Jeff, W.

IPC分类号： C07D401/12 ,  A61K31/47 ,  A61K31/404 ,  A61P13/00 ,  C07D215/12 ,  C07D215/18 ,  C07D215/20 ,  C07D405/12 ,  C07D215/40 ,  C07D215/42 ,  C07D215/26 ,  C07D401/06 ,  C07D417/12 ,  C07D413/12 ,  C07D409/08 ,  C07D413/08 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14

CPC分类号： C07D401/06 ,  C07D215/12 ,  C07D215/18 ,  C07D215/20 ,  C07D215/26 ,  C07D215/40 ,  C07D215/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/08 ,  C07D409/14 ,  C07D413/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Compounds of formula (I) are thus useful for treating disorders of the urinary tract. In the compounds I, R1 = one or more substituents selected from H, halogen, OH, alkyl, haloalkyl, alkoxy, haloalkoxy, NO2, nitro, phenyl, substituted phenyl, heterocycle, substituted heterocycle, NR3R4(R3 and R4 being H, alkyl, acyl or alkoxycarbonyl); R2 = one or two substituents selected from H, alkyl; Y = CH2 or a bond; Q = CO, CS or SO2; A = alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocyclic, alkylamino, dialkylamino, arylamino or arylalkylamino, each of which is optionally substituted; n is 1 or 2; X = an amino moiety selected from formula (a), (b) and -N(R5)-CH2-(R5 = H, methyl, benzyl group; W = bond, N, CH, CH2, C(CN) C(OH) or C(COCH3) (when W represents a nitrogen atom or a CH, C(CN) C(OH) or C(COCH3) group, the group Z-B attaches to the W ring atom); when X is (a) or (b), Z = bond, O, S, CH2, CH2CH2, CO, CHOH, OCH2, NH, NHCO or NHCONHCH2, but when X is -N(R5)-CH2-group, Z represents a CH2CH2 or CH2O group or Z and B together represent a 2,3-dihydro-benzo[1,4]dioxin-2-yl group; and B is a monocyclic or bicyclic aryl group or a monocyclic or bicyclic heterocycle, each of which is optionally substituted.

公开(公告)号：EP0906100B1

公开(公告)日：2004-01-28

申请号：EP97906125.6

申请日：1997-02-25

申请人： RECORDATI S.A. ,  RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.

发明人： LEONARDI, Amedeo ,  TESTA, Rodolfo

IPC分类号： A61K31/495

CPC分类号： A61K31/496

摘要： Compounds which: (a) bind to a 5-HT1A receptor with an affinity of at least 10 M, (b) bind to a 5-HT1A receptor with an affinity at least 50-fold stronger than the affinity with which the compound binds to an alpha 1-adrenergic receptor, and (c) exhibit 5-HT1A receptor antagonist activity on both pre-synaptic and post-synaptic 5-HT1A receptors, and their stereoisomers, hydrates, solvates and pharmaceutically acceptable salts are useful for the treatment of lower urinary tract disorders in mammals.

公开(公告)号：EP1000046B1

公开(公告)日：2003-11-26

申请号：EP98943811.4

申请日：1998-07-31

申请人： RECORDATI S.A. ,  RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.

发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  RIVA, Carlo ,  TESTA, Rodolfo

IPC分类号： C07D295/12 ,  A61K31/495

CPC分类号： C07D295/096 ,  A61K31/495 ,  A61K31/496 ,  C07D213/38 ,  C07D213/56 ,  C07D213/57 ,  C07D295/15 ,  C07D319/18 ,  C07D401/14

摘要： Piperazine derivatives of formula (I) (Ar, Ar' and B are substituted or unsubstituted aryl or heteroaryl groups, Y = N, CH, C-OH, C-CN or C-CONH2, R = H or lower alkyl, Z = CH2 or CH2CH2, Z' = bond or CH2 or CH2CH2) bind to 5HT1A receptors and are useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The use of these compounds for the preparation of a medicament for this treatment is claimed, and some of the compounds (Z = CH2, Z' = bond) are claimed per se.

公开(公告)号：EP1273840A3

公开(公告)日：2003-11-05

申请号：EP02076749.7

申请日：2002-05-01

申请人： KNI Incorporated

发明人： Klaymar, Edward J.

IPC分类号： F16L1/06 ,  F16L3/00

CPC分类号： F16L1/028

摘要： An improved method for supporting an underground pipeline (12) in an excavated trench (14) is disclosed. The method involves supporting the pipeline (12) on specially-designed support benches (20) at spaced intervals. The benches (20) are designed to fail when exposed to a predetermined load, which load will be placed on the benches (20) at some point during the backfilling of the trench (14) or when the pipeline (12) undergoes hydrostatic testing. When the benches (20) fail, the fill (24) under the pipeline (12) is compacted and thereby supports the pipeline (12) in lieu of the support benches (20).

公开(公告)号：EP1324725A2

公开(公告)日：2003-07-09

申请号：EP01980072.1

申请日：2001-10-12

申请人： Biorthex Inc.

发明人： GJUNTER, Victor Eduardovich

IPC分类号： A61F2/44

CPC分类号： A61F2/442 ,  A61F2002/30013 ,  A61F2002/30224 ,  A61F2002/30293 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30668 ,  A61F2002/30769 ,  A61F2230/0069 ,  A61F2230/0091 ,  A61F2250/0001 ,  A61F2250/0024 ,  A61F2310/00023

摘要： An implant device for surgical treatment of spinal disc damage or injury is formed as a resilient body comprising porous TiNi; the body is internally mobile such that it resiliently expands and contracts in response to variation in forces applied externally on the body.

公开(公告)号：EP1312262A1

公开(公告)日：2003-05-21

申请号：EP02079840.1

申请日：2002-11-08

申请人： Taylor, Alan John ,  Roberts, George Andrew Francis ,  Wood, Frances Ann

发明人： Taylor, Alan John ,  Roberts, George Andrew Francis ,  Wood, Frances Ann

IPC分类号： A01N59/16

CPC分类号： A01N59/16 ,  A01N43/16 ,  A01N25/10 ,  A01N25/08 ,  A01N2300/00

摘要： Powders having contact biocidal properties comprise a polysacharide carrying atomic/metallic silver. The preferred polysaccharide is chitin, although other polysaccharides including chitosan, carboxymethyl celluloses and carrageenans can be used. The chitin may be obtained from deproteinated crustacean shells without demineralisation, thus being admixed with calcium carbonate and other naturally occurring minerals present in the shells, and may be enzyme deacetylated.
The powders of the invention can be used as biocidal dusting powders, formulated into pastes, gels, hydrogels, creams, foams and aerosol sprays for pharmaceutical applications, or dissolved to form solutions for coating substrates such as skin, fabrics, glass, leather and paper to give a bactericidal surface. A particular application of such a solution is as a protective, post-wash treatment for workwear in a laundering process.
The powders of the invention may be prepared by slurrying a polysaccharide, which is capable of interacting with silver ions and which is in powder form, in a liquid in which the polymer is insoluble, which liquid contains silver ions, filtering off the powder, washing the powder, reducing the silver ions which have interacted with the polysaccharide to atomic/metallic silver, and drying the powder. According to the polysaccharide chosen, the liquid is suitably water or aqueous ethanol. The silver ions may derive from silver nitrate. The reduction of the silver ions which have interacted with the polysaccharide to atomic/metallic silver can be effected photochemically through exposure to light. To hasten the reduction, however, the washed powder is preferably slurried in a solution of an alkali metal halide, irradiated under stirring with natural or artificial light containing an ultraviolet component, and again filtered off and washed, before drying it.

摘要翻译： 具有接触杀生物性的粉末包含携带原子/金属银的多糖。 优选的多糖是几丁质，尽管可以使用包括壳聚糖，羧甲基纤维素和角叉菜胶的其它多糖。 几丁质可以从去蛋白化甲壳类壳体获得，而不脱矿质，因此与壳中存在的碳酸钙和其他天然存在的矿物质混合，并且可以是酶脱乙酰化的。 本发明的粉末可以用作杀菌粉剂，配制成糊剂，凝胶剂，水凝胶，霜剂，泡沫剂和用于药物应用的泡沫喷雾剂，或溶解形成用于涂覆底物如皮肤，织物，玻璃，皮革和纸张的溶液 给予杀菌表面。 这种解决方案的具体应用是作为洗涤过程中工作服的保护性洗后处理。 本发明的粉末可以通过将能够与银离子相互作用并且呈粉末形式的多糖在聚合物不溶的液体中分散，该液体含有银离子，过滤粉末，洗涤 粉末，将与多糖相互作用的银离子还原成原子/金属银，并干燥粉末。 根据所选择的多糖，液体适宜为水或乙醇水溶液。 银离子可以来自硝酸银。 与多糖与原子/金属银相互作用的银离子的还原可以通过曝光光光化学实现。 然而，为了加速还原，优选将洗涤过的粉末在碱性金属卤化物的溶液中浆化，在搅拌下用包含紫外线成分的天然或人造光照射，再次过滤并洗涤，然后干燥。

公开(公告)号：EP1283864A2

公开(公告)日：2003-02-19

申请号：EP01933079.4

申请日：2001-05-04

申请人： Independent Stave Co.

发明人： SWAN, James S.

IPC分类号： C12H1/056 ,  A23L2/80 ,  A23L1/015

CPC分类号： A23L2/80 ,  A23L5/273 ,  C12H1/0424

摘要： A process of removing off-flavors and off-odors, such as caused by trichloroanisole (TCA), from food or beverage products by contacting the food or beverage with one or more aliphatic synthetic polymers so as to sufficiently lower the concentration of the off-flavors and off-odors that they are undetectable by taste or smell. The concentration of the TCA is lowered to about 10 ppt or less.

公开(公告)号：EP1235622A1

公开(公告)日：2002-09-04

申请号：EP00954125.1

申请日：2000-08-17

申请人： The University of Chicago

发明人： DATTA, Rathin ,  LIN, YuPo ,  BURKE, Dennis ,  TSAI, Shih-Perng

IPC分类号： B01D24/00 ,  B01D61/46 ,  B01D61/48 ,  C08J5/20

CPC分类号： B01D61/48 ,  B01J47/018 ,  B01J47/08 ,  C02F1/42 ,  C02F1/4604 ,  C02F1/469 ,  C08J5/20

摘要： A porous immobilized ion-exchange material (30) is provided and secured in an opening (34). Also provided is an electrodeionization device incorporating the material (30). A method for subjecting a fluid to electrodeionization, is provided utilizing porous immobilized ion-exchange material (30). A salient feature of the material (30) is that it can be regenerated.

摘要翻译： 多孔固定化离子交换材料（30）被提供并固定在开口（34）中。 还提供了包含材料（30）的电去离子装置。 利用多孔固定化离子交换材料（30）提供使流体经历电去离子化的方法。 材料（30）的突出特点是可以再生。

公开(公告)号：EP1219143A1

公开(公告)日：2002-07-03

申请号：EP00962065.9

申请日：2000-09-08

申请人： Pillinger, Barry Ernest

发明人： Pillinger, Barry Ernest

IPC分类号： H05B3/84 ,  H05B3/86 ,  A47G1/00 ,  A47F11/04 ,  B60R1/00 ,  G02B5/08

CPC分类号： H05B3/845 ,  A47G1/02 ,  G02B7/1815 ,  H05B3/86

摘要： An anti-fogging mirror assembly (10) comprises a mirrored sheet (12), a second sheet (16), and a bonding medium (18) adapted to bond together the mirrored sheet (12) and the second sheet (16). The bonding medium (18) has embedded in it a heating pad (20) in the form of an electrical resistance heating element, which, when it is supplied with electrical energy, heats the mirrored sheet (12) such that any moisture on the mirrored sheet (12) is evaporated, and condensation of moisture on the mirrored sheet (12) is prevented. The heating element (20) may be in the form of a polyester substrate printed with a conductive ink, and electrical energy to the heating element (20) may be supplied through upper (68) and lower (26) bus bars. A thermostat (54) may be provided such that when the heating element (20) reaches a predetermined temperature electrical energy is no longer supplied to the heating element (20).

公开(公告)号：EP1043974B1

公开(公告)日：2002-04-03

申请号：EP98966710.0

申请日：1998-12-28

申请人： Cellpep S.A.

发明人： DE ROUGE, Bonabes-Olivier

IPC分类号： A61K9/127 ,  A61K38/16 ,  A61P31/18

CPC分类号： A61K9/127 ,  A61K38/162

摘要： The incorporation of multiple branch peptide constructions having activity against HIV (such as those described in WO 95/07929 and WO 98/29443) into liposomes of sufficient size for white blood cell internalisation (e.g. greater than 150 nm and preferably approximately 250 to 400 nm) has been shown to increase the activity of those MBPCs manifold. The liposomes and pharmaceutical compositions containing them are claimed.