公开(公告)号：EP4461354A2

公开(公告)日：2024-11-13

申请号：EP24193389.4

申请日：2010-11-11

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  WALTER, Korden ,  WÖLL, Stefan ,  KREUZBERG, Maria ,  HUBNER, Bernd ,  ERDELJAN, Michael

IPC分类号： A61P1/18

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

公开(公告)号：EP4285911A3

公开(公告)日：2024-04-10

申请号：EP23200924.1

申请日：2010-02-19

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  HELFTENBEIN, Gerd ,  KORDEN, Walter ,  WÖLL, Stefan ,  OPREA, Gabriela-Elena

IPC分类号： C12N15/11 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/04 ,  C12N15/113

摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.

公开(公告)号：EP4331578A2

公开(公告)日：2024-03-06

申请号：EP23209136.3

申请日：2016-04-13

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  WALTER, Korden ,  KREUZBERG, Maria ,  MITNACHT-KRAUS, Rita ,  LE GALL, Fabrice ,  JACOBS, Stefan

IPC分类号： A61K31/40

摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

公开(公告)号：EP4112645A1

公开(公告)日：2023-01-04

申请号：EP22154316.8

申请日：2006-11-24

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  USENER, Dirk ,  FRITZ, Stefan ,  UHEREK, Christoph ,  BRANDENBURG, Gunda ,  GEPPERT, Harald-Gerhard ,  SCHRÖDER, Anja Kristina ,  THIEL, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K51/10 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61P35/04 ,  A61P43/00

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP4036119A1

公开(公告)日：2022-08-03

申请号：EP22152178.4

申请日：2013-05-06

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  MITNACHT-KRAUS, Rita ,  WÖLL, Stefan

IPC分类号： C07K16/30 ,  A61P37/00

摘要： The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.

公开(公告)号：EP3791896A1

公开(公告)日：2021-03-17

申请号：EP20194625.8

申请日：2013-05-21

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  MITNACHT-KRAUS, Rita ,  JACOBS, Stefan, Denis ,  UTSCH, Magdalena, Jadwiga ,  HEINZ, Cornelia, Adriana, Maria ,  STADLER, Christiane, Regina

IPC分类号： A61K39/395 ,  C07K16/30 ,  A61K45/06

摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

公开(公告)号：EP3027208B1

公开(公告)日：2020-06-24

申请号：EP14750331.2

申请日：2014-07-30

申请人： Biontech AG ,  Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  WALTER, Korden ,  WAGNER, Meike ,  KREUZBERG, Maria ,  HÄCKER, Sabine ,  JACOBS, Stefan

IPC分类号： A61K39/395 ,  G01N33/50

公开(公告)号：EP3421499A1

公开(公告)日：2019-01-02

申请号：EP18188488.3

申请日：2011-03-10

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  KOSLOWSKI, Michael ,  MITNACHT-KRAUS, Rita

IPC分类号： C07K16/30

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.

公开(公告)号：EP3254695A1

公开(公告)日：2017-12-13

申请号：EP17171169.0

申请日：2013-05-21

申请人： GANYMED Pharmaceuticals AG ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  MITNACHT-KRAUS, Rita ,  JACOBS, Stefan, Denis ,  UTSCH, Magdalena, Jadwiga ,  HEINZ, Cornelia, Adriana, Maria ,  STADLER, Christiane, Regina

IPC分类号： A61K39/395 ,  C07K16/30 ,  A61K45/06

摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

公开(公告)号：EP4364756A2

公开(公告)日：2024-05-08

申请号：EP24150410.9

申请日：2013-05-21

申请人： Astellas Pharma Inc. ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  MITNACHT-KRAUS, Rita ,  JACOBS, Denis Stefan ,  UTSCH, Magdalena Jadwiga ,  HEINZ, Cornelia Adriana Maria ,  STADLER, Christiane Regina

IPC分类号： A61K45/06

CPC分类号： A61K39/39558 ,  A61K45/06 ,  C07K16/30 ,  C07K16/3046

摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.