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公开(公告)号：EP4242236A3
公开(公告)日：2023-11-22
申请号：EP23155995.6
申请日：2008-05-27
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12 , C07K16/28 , A61P35/04 , A61P43/00 , A61P37/04
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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公开(公告)号：EP4119582A1
公开(公告)日：2023-01-18
申请号：EP22181929.5
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3679069A1
公开(公告)日：2020-07-15
申请号：EP18765858.8
申请日：2018-09-05
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/28
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公开(公告)号：EP2852409B1
公开(公告)日：2020-03-25
申请号：EP13729591.1
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
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公开(公告)号：EP2976360B1
公开(公告)日：2019-11-27
申请号：EP14714586.6
申请日：2014-03-17
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61P35/00
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公开(公告)号：EP3401334A1
公开(公告)日：2018-11-14
申请号：EP18168460.6
申请日：2008-05-27
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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公开(公告)号：EP4364756A3
公开(公告)日：2024-07-31
申请号：EP24150410.9
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Denis Stefan , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06 , A61P35/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K16/30 , C07K16/3046 , A61K2039/50520130101 , A61P35/00 , C07K2317/73220130101 , C07K2317/7320130101 , C07K2317/73420130101
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4285911A2
公开(公告)日：2023-12-06
申请号：EP23200924.1
申请日：2010-02-19
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HELFTENBEIN, Gerd , KORDEN, Walter , WÖLL, Stefan , OPREA, Gabriela-Elena
IPC分类号： A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：EP4242236A2
公开(公告)日：2023-09-13
申请号：EP23155995.6
申请日：2008-05-27
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/28
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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公开(公告)号：EP3738611A1
公开(公告)日：2020-11-18
申请号：EP20180951.4
申请日：2014-07-30
申请人： BioNTech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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