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公开(公告)号：EP1341464A4
公开(公告)日：2009-07-22
申请号：EP01959004
申请日：2001-07-19
申请人： CERAMOPTEC GMBH
CPC分类号： A61K9/0014 , A61B18/22 , A61B2017/22054 , A61B2018/00982 , A61B2018/2261 , A61K47/32 , A61K47/34 , A61N5/0601 , A61N5/062
摘要： An apparatus and method for treating epithelial hyperproliferative diseases by application of an active composition over the diseased irregular tissue which is in the form of a viscous gel to carry the photosensitizer. The gel's viscosity allows it to adhere to the tissue for a sufficient time to transfer the photosensitizer or for a mechanical device such an expanding balloon to press the gel into the tissue. The photosensitizer within the gel is activated by the corresponding wavelenght of radiation. An extended multi-ballon system limits the area of treatment and localizes the spread of the gel. The apparatus, designed to be used with an endoscope, contains a catheter with at least two balloons, one to block drainage of the gel and one to limit the height of the treatment area and to press the gelinto the tissue.
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公开(公告)号：EP1211997A4
公开(公告)日：2009-06-17
申请号：EP00957381
申请日：2000-08-10
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG
CPC分类号： A61B18/22 , A61B17/3213 , A61B2018/2261
摘要： A device that simultaneously incises an area and cauterizes the desired tissue. The device incorporates laser energy by some means into a mechanical scalpel so that the incised area is cauterized as well. For example, a laser source is coupled by some means to an optically transparent blade such as a diamond knife. The diamond knife is appropriately coated so that radiation only exits at desired areas. In another example, optical fibers are embedded into a sharp edge blade scalpel with means to couple to a suitable radiation source.
摘要翻译： 同时切割区域并烧灼所需组织的装置。 该装置通过一些手段将激光能量结合到机械手术刀中，从而切开的区域也被烧灼。 例如，激光源通过一些装置耦合到诸如金刚石刀之类的光学透明刀片。 钻石刀适当涂层，以便辐射只在所需区域退出。 在另一个例子中，光纤被嵌入锋利的刃刀片手术刀中，其具有耦合到合适的辐射源的装置。
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公开(公告)号：EP1324663A4
公开(公告)日：2004-01-14
申请号：EP01966064
申请日：2001-08-22
申请人： CERAMOPTEC GMBH
CPC分类号： A61K31/00
摘要： A new approach for targeting chemotherapeutics to focal bacterial infections is provided. Such focal infections are characterized by high densities of different bacteria and thus high concentrations of their extracellular signal molecules sensing the cell density. In gram-negative bacteria, one of such signal molecules is acylhomoserine lactone (acyl-HSL, member of the autoinducer family AI-1), wherein species-specificity is achieved by acyl-residues, and HSLs are common for all gram-negative bacteria. In gram-positive bacteria, oligopeptides secreted by the bacteria communicate the cell density. In addition, there are cell density signal molecules (members of the autoinducer family AI-2) which communicate between gram-positive and gram-negative bacteria. The general scheme of the present invention is molecular modules that comprise both a targeting component and a chemotherapeutical component which serves for photodynamic antimicrobial chemotherapy (PACT). One preferred embodiment of the present invention is to target photosensitizers to the extracellular signal molecules instead of on the bacteria themselves. Targeting of the photosensitizers is mediated via molecules with efficient binding to the HSL-moiety of the acyl-HSL, so that a broad spectrum of gram-negative bacteria can be knocked out. Photosensitizers used in the present invention can be packed into special liposomes with lipid chelators or multiple coupled to dendrimers, so that they are especially effective for PACT. In addition, selected molecules with high affinity to a common moiety of such signal molecules, like HSL, may be used as molecular probes for the search of yet undiscovered cell density dependent signals.
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