公开(公告)号：EP2079744A1

公开(公告)日：2009-07-22

申请号：EP07819422.2

申请日：2007-10-29

申请人： NOVARTIS AG

发明人： CAPRARO, Hans-Georg ,  FURET, Pascal ,  IMBACH, Patricia ,  STAUFFER, Frédéric

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The invention relates to novel compounds of the formula (I), as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or human body in view of their ability to inhibit protein kinases such as especially PI3 kinase.

公开(公告)号：EP2079702A1

公开(公告)日：2009-07-22

申请号：EP07821990.4

申请日：2007-10-29

申请人： NOVARTIS AG

发明人： HOLZER, Philipp ,  IMBACH, Patricia ,  FURET, Pascal

IPC分类号： C07D231/38 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D231/38

摘要： The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

公开(公告)号：EP1670771A1

公开(公告)日：2006-06-21

申请号：EP04789483.7

申请日：2004-09-30

申请人： IRM, LLC ,  Novartis AG

发明人： CHOPIUK, Greg ,  FURET, Pascal ,  GRAY , Nathanael, Schiander ,  IMBACH, Patricia ,  LIU, YI ,  SCHOEPFER, Joseph ,  STEENSMA, Ruo

IPC分类号： C07D251/48 ,  C07D239/02 ,  C07D403/00 ,  A61K31/53 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D239/26 ,  A61K31/5377 ,  C07D239/42 ,  C07D403/12

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGFβ , KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

摘要翻译： 本发明提供了一类新化合物，包含此类化合物的药物组合物以及使用此类化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及Abl，BCR-Abl异常活化的疾病或病症的方法 EGFR，c-erbB2激酶（HER-2），CHK2，FGFR3，p70S6K，PKC，PDGF-R，p38，TGFβ，KDR，c-Kit，b-RAF，c-RAF，FLT1和/ 激酶。