公开(公告)号：EP1896435A1

公开(公告)日：2008-03-12

申请号：EP06753938.7

申请日：2006-05-27

申请人： Sanofi-Aventis

发明人： ZOLLER, Gerhard ,  PETRY, Stefan ,  MÜLLER, Günter ,  HEUER, Hubert ,  TENNAGELS, Norbert

IPC分类号： C07D277/68 ,  A61K31/428 ,  A61P3/10

CPC分类号： C07D277/68

摘要： The invention relates to benzothiazol-2-on derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances.

公开(公告)号：EP1771426B1

公开(公告)日：2007-12-19

申请号：EP05756578.0

申请日：2005-07-02

申请人： Sanofi-Aventis Deutschland GmbH

发明人： PETRY, Stefan ,  BARINGHAUS, Karl-Heinz ,  TENNAGELS, Norbert ,  MUELLER, Guenter ,  KIRSCH, Reinhard

IPC分类号： C07D277/42 ,  C07D277/46 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07D277/42 ,  C07D277/46

摘要： The aim of the invention is to provide compounds having a therapeutic blood-sugar decreasing effect. Said compounds are suitable especially for the prevention and treatment of pancreatic diabetes. To this end, the invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 independently represent H, F, Cl, Br, J, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-alkyl, O-(C1-C4)-alkoxy-(C1-C4)-alkyl, S-(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O-(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, O-(C3-C8)-cycloalkenyl, (C2-C6)-alkinyl, aryl, O-aryl, (C1-C8)alkylene-aryl, O-(C1-C8)-alkylene-aryl, S-aryl, CO-NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH-SO2-CH3, SO2-CH3, COOH, COO-(C1-C6)-alkyl, or CO-N((C1-C6)-alkyl)2; R6 represents H, (C1-C6)-alkyl; A represents a bond, -CH2-, -NH-, -CH2-O-, -S-, -CH2-CH2-, or -CH(CH3)-; B represents NH, NH(C1-C4)-alkyl, or NH(CO); and D represents phenyl or a heterocycle. The invention also relates to the physiologically compatible salts of said compounds.