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公开(公告)号：EP1664117A4
公开(公告)日：2008-07-16
申请号：EP04784032
申请日：2004-09-14
申请人： UNIV DUKE
发明人： HAYNES BARTON F , PATEL DHAVALKUMAR D , ALAM MUNIR , LIAO HUA-XIN
IPC分类号： A61K39/21 , A61K20060101 , A61K39/38 , A61K39/385 , A61K47/48 , C07K14/16 , C07K16/00 , C07K16/10
CPC分类号： C07K16/1063 , A61K39/12 , A61K39/21 , A61K47/646 , A61K47/6841 , A61K2039/505 , C07K14/005 , C07K2317/76 , C12N2710/24143 , C12N2740/16122 , C12N2740/16134 , Y10S530/826
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公开(公告)号：EP3201227A4
公开(公告)日：2018-04-18
申请号：EP15846994
申请日：2015-09-29
发明人： HAYNES BARTON F , FERRARI GUIDO , KOENIG SCOTT , JOHNSON LESLIE S , LAM CHIA YING KAO , SUNG JULIA A , MARGOLIS DAVID M , LIU LIQIN , NORDSTROM JEFFREY LEE
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , C07K16/2809 , C07K16/283 , C07K16/44 , C07K2317/31 , C07K2317/52 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.
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公开(公告)号：EP3197488A4
公开(公告)日：2018-03-21
申请号：EP15843595
申请日：2015-09-25
发明人： HAYNES BARTON F , LIAO HUA XIN , KORBER BETTE T , HRABER PETER T
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K31/4706 , A61K39/12 , A61K39/3955 , A61K47/48276 , A61K47/4833 , A61K47/48338 , A61K47/48815 , A61K2039/505 , A61K2039/545 , A61K2039/6018 , A61K2039/627 , C07K14/70578 , C07K2319/70 , C12N7/00 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
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公开(公告)号：EP3122881A4
公开(公告)日：2017-11-15
申请号：EP15769306
申请日：2015-03-25
发明人： HAYNES BARTON F , KORBER BETTE T
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/70 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
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公开(公告)号：EP3003372A4
公开(公告)日：2017-05-17
申请号：EP14806951
申请日：2014-06-07
申请人： UNIV DUKE
发明人： PATZ JR EDWARD F , CAMPA MICHAEL J , GOTTLIN ELIZABETH , HAYNES BARTON F , LIAO HUA-XIN , MOODY M ANTHONY
IPC分类号： A61K39/395 , A61K39/00 , C07K14/72 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K14/72 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/73 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6878 , G01N2333/4716
摘要： Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
摘要翻译： 本文公开了补体因子H（CFH）抑制剂，例如抗CFH抗体和小分子，以及使用所述抑制剂的方法。
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公开(公告)号：EP2986628A4
公开(公告)日：2016-09-21
申请号：EP14785257
申请日：2014-04-15
申请人： UNIV DUKE , GOVERNMENT OF THE US AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INST , JACKSON H M FOUND MILITARY MED , LOS ALAMOS NAT SECURITY LLC
发明人： KIM JEROME , ROLLAND MORGANE , KORBER BETTE T , HAYNES BARTON F
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
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47.发明公开METHOD FOR THE GENERATION OF MONOCLONAL ANTIBODIES DERIVED FROM HUMAN B CELLS 审中-公开产生来自人B细胞的单克隆抗体的方法
公开(公告)号：EP2556148A4
公开(公告)日：2013-12-11
申请号：EP11766283
申请日：2011-04-11
申请人： UNIV DUKE
发明人： HAYNES BARTON F , BONSIGNORI MATTIA , HWANG KWAN-KI , LIAO HUA-XIN , MONTEFIORI DAVID C , LUFTIG MICAH A
IPC分类号： C12N5/0781 , C07K16/00 , C07K16/10 , C07K16/18 , C12N5/10
CPC分类号： C07K16/00 , C07K16/1045 , C07K2317/76
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公开(公告)号：EP2331104A4
公开(公告)日：2012-10-17
申请号：EP09811855
申请日：2009-09-08
申请人： UNIV DUKE
发明人： HAYNES BARTON F
IPC分类号： A61K31/685 , A61K39/00 , A61P31/18
CPC分类号： A61K31/685 , A61K9/0019 , A61K9/006 , A61K39/0005 , A61K39/0012 , A61K2039/53 , A61K2039/55572 , A61K2039/6037 , A61K2039/6081
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49.发明公开
公开(公告)号：EP2335069A4
公开(公告)日：2012-08-01
申请号：EP09816574
申请日：2009-09-24
申请人： UNIV DUKE
发明人： TOMARAS GEORGIA , HAYNES BARTON F , LIU PINGHUANG , YATES NICOLE , HWANG KWAN-KI
IPC分类号： G01N33/53 , C07K16/10 , C12Q1/68 , G01N33/569
CPC分类号： C07K16/1063 , G01N33/56988
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公开(公告)号：EP2129395A4
公开(公告)日：2012-05-09
申请号：EP08799657
申请日：2008-03-27
申请人： UNIV CALIFORNIA , UNIV DUKE , UNIV ALABAMA , UNIV NORTH CAROLINA
发明人： HAYNES BARTON F , KORBER BETTE T , HAHN BEATRICE H , BHATTACHARYA TANMOY , GNANAKARAN GNANA S , GAO FENG , SWANSTROM RON , SHAW GEORGE
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134
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