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公开(公告)号：EP2986628A4
公开(公告)日：2016-09-21
申请号：EP14785257
申请日：2014-04-15
申请人： UNIV DUKE , GOVERNMENT OF THE US AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INST , JACKSON H M FOUND MILITARY MED , LOS ALAMOS NAT SECURITY LLC
发明人： KIM JEROME , ROLLAND MORGANE , KORBER BETTE T , HAYNES BARTON F
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
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公开(公告)号：EP2900693A4
公开(公告)日：2016-05-11
申请号：EP13841395
申请日：2013-09-26
申请人： UNIV DUKE , GOVERNMENT OF THE US AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INST
发明人： HAYNES BARTON F , BONSIGNORI MATTIA , LIAO HUA-XIN , FERRARI GUIDO , MOODY MICHAEL A , KIM JEROME , MICHAEL NELSON , POLLARA JUSTIN
CPC分类号： C07K16/1063 , A61K39/42 , A61K2039/507 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/732 , C07K2317/76
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公开(公告)号：EP2739300A4
公开(公告)日：2015-06-03
申请号：EP12807743
申请日：2012-07-05
申请人： UNIV DUKE , CHILDRENS MEDICAL CENTER , GOVERNMENT OF THE US AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INST
IPC分类号： A61K38/17 , A61K38/16 , A61K39/21 , A61K39/245 , A61K48/00 , A61P31/00 , A61P37/00 , C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/6075 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/92 , C07K2319/40 , C12N2710/16622 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
摘要翻译： 本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及用于HIV-1的疫苗及其制备和使用方法。
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4.发明公开CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS 审中-公开CAP260-，CAP174- UND K0224-HIV-1信封，肽和佐剂明胶
公开(公告)号：EP3083661A4
公开(公告)日：2017-06-28
申请号：EP14870945
申请日：2014-12-18
发明人： HAYNES BARTON F , KORBER BETTE T
IPC分类号： C07K14/155 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/295 , A61K39/39 , C07K14/005 , C12N7/00 , C12N15/49 , C12N15/63 , C12N15/863
CPC分类号： A61K39/21 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
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公开(公告)号：EP3119890A4
公开(公告)日：2017-12-27
申请号：EP15764507
申请日：2015-03-19
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HRABER PETER T
IPC分类号： C12N15/46 , A61K39/21 , C07K14/155 , C12N15/85
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16134
摘要： In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
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公开(公告)号：EP2318430A4
公开(公告)日：2012-08-29
申请号：EP09806982
申请日：2009-08-14
发明人： KORBER BETTE T , FISCHER WILLIAM , LETVIN NORMAN , LIAO HUA-XIN , HAYNES BARTON F , HAHN BEATRICE H
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
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公开(公告)号：EP3126502A4
公开(公告)日：2018-01-17
申请号：EP15772335
申请日：2015-03-31
IPC分类号： C12N15/49 , A61K31/7088 , A61K39/21 , C07K14/155
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
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公开(公告)号：EP2895500A4
公开(公告)日：2016-04-13
申请号：EP13837551
申请日：2013-09-12
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , UNIV PENNSYLVANIA , UNIV BOSTON , US GOV HEALTH & HUMAN SERV , UNIV LELAND STANFORD JUNIOR
发明人： HAYNES BARTON F , LIAO HUA-XIN , LYNCH REBECCA M , ZHOU TONGQING , GAO FENG , BOYD SCOTT , SHAW GEORGE M , HAHN BEATRICE H , KEPLER THOMAS B , KORBER BETTE T , KWONG PETER , MASCOLA JOHN
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
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公开(公告)号：EP3197488A4
公开(公告)日：2018-03-21
申请号：EP15843595
申请日：2015-09-25
发明人： HAYNES BARTON F , LIAO HUA XIN , KORBER BETTE T , HRABER PETER T
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K31/4706 , A61K39/12 , A61K39/3955 , A61K47/48276 , A61K47/4833 , A61K47/48338 , A61K47/48815 , A61K2039/505 , A61K2039/545 , A61K2039/6018 , A61K2039/627 , C07K14/70578 , C07K2319/70 , C12N7/00 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
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公开(公告)号：EP3122881A4
公开(公告)日：2017-11-15
申请号：EP15769306
申请日：2015-03-25
发明人： HAYNES BARTON F , KORBER BETTE T
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/70 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
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