公开(公告)号：EP2943509B1

公开(公告)日：2019-04-10

申请号：EP14700572.2

申请日：2014-01-09

申请人： BioInvent International AB

发明人： FRENDEUS, Björn ,  HANSSON, Markus

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K39/00

公开(公告)号：EP1960432B1

公开(公告)日：2016-04-06

申请号：EP06829616.9

申请日：2006-12-08

申请人： BioInvent International AB

发明人： FRENDÉUS, Björn ,  CARLSSON, Roland

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/2821 ,  C07K16/2833 ,  C07K16/4283 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/94

摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.

摘要翻译： 本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞凋亡。 还提供了用于凋亡诱导的方法和药物组合物及其用途。

公开(公告)号：EP2649098A1

公开(公告)日：2013-10-16

申请号：EP11804984.0

申请日：2011-12-12

申请人： BioInvent International AB

发明人： TEIGE, Ingrid

IPC分类号： C07K16/28 ,  A61K39/02

摘要： The invention relates to antibodies for inducing cell death by the specific binding of (ROR1), domains thereof or nucleotide molecules encoding (ROR1). There are also provided methods involving and uses of the antibodies of the invention.

公开(公告)号：EP2513146A2

公开(公告)日：2012-10-24

申请号：EP10798728.1

申请日：2010-12-10

申请人： BioInvent International AB

发明人： MELLSTEDT, Håkan ,  RABBANI, Hodjattallah ,  TEIGE, Ingrid

IPC分类号： C07K16/28

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14

摘要： The invention relates to antibodies and siRNA molecules for inducing cell death by the specific binding of ROR1, domains thereof or nucleotide molecules encoding ROR1. There are also provided methods involving and uses of the antibodies and siRNA molecules of the invention.

公开(公告)号：EP2470210A2

公开(公告)日：2012-07-04

申请号：EP10812677.2

申请日：2010-08-27

申请人： BioInvent International AB ,  Genentech, Inc. ,  Oregon Health and Science University

发明人： BUNTING, Stuart ,  BULLENS, Sherron ,  CARLSSON, Roland ,  FRENDEUS, Björn ,  GLAZER, Steven ,  GROVE, Kevin ,  VAN BRUGGEN, Nick

IPC分类号： A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/94

摘要： The present invention relates to methods and compositions for increasing insulin sensitivity comprising the administration of anti-oxidized LDL antibodies.

公开(公告)号：EP2468775A1

公开(公告)日：2012-06-27

申请号：EP11195698.3

申请日：2006-12-08

申请人： BioInvent International AB

发明人： Frendéus, Björn ,  Carlsson, Roland

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/02

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/2821 ,  C07K16/2833 ,  C07K16/4283 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/94

摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.

摘要翻译： 本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞凋亡。 还提供了用于凋亡诱导的方法和药物组合物及其用途。

公开(公告)号：EP2010212A2

公开(公告)日：2009-01-07

申请号：EP07724157.8

申请日：2007-04-11

申请人： BioInvent International AB

发明人： BORREBAECK, Carl ,  FRANSSON, Johan

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K51/10 ,  C07K16/30

CPC分类号： C07K16/30 ,  A61K47/6809 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/77 ,  G01N33/57492

摘要： The present application relates to agents, compositions and methods for use in medicine. In particular, the application relates to an agent comprising a binding moiety capable of selectively binding to Ku protein for use in medicine, in particular in the treatment and diagnosis of cancers.

公开(公告)号：EP1535069B1

公开(公告)日：2008-08-06

申请号：EP03793817.2

申请日：2003-09-03

申请人： BioInvent International AB

发明人： FRENDEUS, Björn

IPC分类号： G01N33/53 ,  C12Q1/68

CPC分类号： C40B30/04 ,  C12N15/1037 ,  G01N33/554 ,  G01N33/6845

摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.

公开(公告)号：EP1928913A2

公开(公告)日：2008-06-11

申请号：EP06777156.8

申请日：2006-09-04

申请人： BioInvent International AB

发明人： CARLSSON, Roland ,  NILSSON, Jan

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61K39/00 ,  A61P9/10 ,  A61K31/33 ,  G01N33/68 ,  G01N33/53

CPC分类号： C07K16/18 ,  A61K39/0012 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/622 ,  Y02A50/407

摘要： The use of immunotherapy against oxidised LDL to induce regression of pre-existing atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.

公开(公告)号：EP1696950A2

公开(公告)日：2006-09-06

申请号：EP04804169.3

申请日：2004-12-20

申请人： BIOINVENT INTERNATIONAL AB

发明人： KIESSLING, Rolf ,  HOLMGREN, Lars

IPC分类号： A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P27/00 ,  A61P29/00 ,  A61P43/00

CPC分类号： C07K14/71 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2300/00

摘要： A vaccine for preventing formation of blood vessels, for example neoangiogenesis, as well as repressing existing vascularization associated with tumors and other diseases, comprising angiomotin, for example as a whole molecule or fragment thereof or encoded as a gene or mRNA, or administered as dendritic cells (DC cells) expressing angiomotin, which may be utilized to generate immune responses to the angiomotin molecule. Inhibition of angiogenesis and delay in tumor outgrowth in animal models of cancer is achieved.