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1.发明公开USE OF ANTIBODIES AGAINST ICAM-1 IN THE TREATMENT OF PATIENTS WITH RELAPSED CANCER 审中-公开抗体与ICAM-1使用肿瘤患者复发治疗
公开(公告)号：EP2593481A1
公开(公告)日：2013-05-22
申请号：EP11749359.3
申请日：2011-07-13
发明人： HANSSON, Markus , FRENDEUS, Björn
IPC分类号： C07K16/28
CPC分类号： C07K16/2821 , A61K9/0019 , A61K9/20 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, for use in the treatment of cancer in patients who have previously been treated for cancer and either not responded to said treatment or have previously responded to said treatment and subsequently relapsed.
摘要翻译： 本发明提供抗体或其抗原结合片段具有结合特异性为ICAM-1，用于在患者中治疗癌症中的用途谁先前已经治疗癌症和要么没有响应所述治疗或之前响应所述治疗，随后其 复发。
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2.发明公开METHOD FOR SCREENING ANTI-LIGAND LIBRARIES FOR IDENTIFYING ANTI-LIGANDS SPECIFIC FOR DIFFERENTIALLY AND INFREQUENTLY EXPRESSED LIGANDS 有权一种筛选抗配图书馆用于鉴定抗特异性的配体为不同的和罕见的EXPERIMIERTE配位体
公开(公告)号：EP1535069A1
公开(公告)日：2005-06-01
申请号：EP03793817.2
申请日：2003-09-03
发明人： FRENDEUS, Björn
CPC分类号： C40B30/04 , C12N15/1037 , G01N33/554 , G01N33/6845
摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
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3.发明公开USE OF ANTIBODIES AGAINST ICAM-1 IN COMBINATION WITH AN ANTI CANCER DRUG IN THE TREATMENT OF PATIENTS 审中-公开TO ICAM-1抗体的结合使用具有中等对癌症治疗的患者
公开(公告)号：EP2943509A1
公开(公告)日：2015-11-18
申请号：EP14700572.2
申请日：2014-01-09
发明人： FRENDEUS, Björn , HANSSON, Markus
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/454 , A61K31/573 , A61K38/05 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/2821 , C07K2317/21 , C07K2317/73 , C07K2317/732 , A61K2300/00
摘要： There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, together with further anti-cancer agents, and compositions thereof, for use in the treatment of cancer.
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公开(公告)号：EP2943509B1
公开(公告)日：2019-04-10
申请号：EP14700572.2
申请日：2014-01-09
发明人： FRENDEUS, Björn , HANSSON, Markus
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K39/00
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公开(公告)号：EP2470210A2
公开(公告)日：2012-07-04
申请号：EP10812677.2
申请日：2010-08-27
发明人： BUNTING, Stuart , BULLENS, Sherron , CARLSSON, Roland , FRENDEUS, Björn , GLAZER, Steven , GROVE, Kevin , VAN BRUGGEN, Nick
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/94
摘要： The present invention relates to methods and compositions for increasing insulin sensitivity comprising the administration of anti-oxidized LDL antibodies.
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6.发明授权METHOD FOR SCREENING ANTI-LIGAND LIBRARIES FOR IDENTIFYING ANTI-LIGANDS SPECIFIC FOR DIFFERENTIALLY AND INFREQUENTLY EXPRESSED LIGANDS 有权一种筛选抗配图书馆用于鉴定抗特异性的配体为不同的和罕见的EXPERIMIERTE配位体
公开(公告)号：EP1535069B1
公开(公告)日：2008-08-06
申请号：EP03793817.2
申请日：2003-09-03
发明人： FRENDEUS, Björn
CPC分类号： C40B30/04 , C12N15/1037 , G01N33/554 , G01N33/6845
摘要： The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands; providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
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