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    Acid addition salts of 5-aminolevulinic acid or its derivatives
    43.
    发明公开
    Acid addition salts of 5-aminolevulinic acid or its derivatives 有权
    纯净水添加剂5-AMINOLEVULINSÄERODER IHRER DERIVATE

    公开(公告)号：EP2308830A1

    公开(公告)日：2011-04-13

    申请号：EP10011759.7

    申请日：2005-03-29

    申请人： Photocure ASA

    发明人： Braenden, Jon, Erik ,  Godal, Aslak ,  Nilsen, Nils, Olav ,  Klaveness, Jo

    IPC分类号： C07C229/22 ,  A61K31/195

    CPC分类号： A61K41/0061 ,  C07C229/22

    摘要： The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

    摘要翻译： 本发明提供5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与酸的加成盐，其酸值为约5或更小，优选约3或更小， 较少，条件是酸不是盐酸。 特别优选的盐是衍生自选自磺酸及其衍生物，氢溴酸，硫酸，硝酸和磷酸的酸的酸。 根据本发明的盐特别适用于诊断和光化学治疗身体的外表面或内表面的病症或异常的光敏剂。

    Compounds for Dual Photodiagnosis and Therapy
    44.
    发明公开
    Compounds for Dual Photodiagnosis and Therapy 审中-公开
    Verbindungen zur Fotodiagnose und Therapie

    公开(公告)号：EP2270107A1

    公开(公告)日：2011-01-05

    申请号：EP10184629.3

    申请日：2004-10-07

    申请人： Mallinckrodt Inc.

    发明人： Achilefu, Samuel ,  Rajagopalan, Raghavan ,  Dorshow, Richard B. ,  Bugaj, Joseph E. ,  Periasamy, Muthunadar P.

    IPC分类号： C09B47/00 ,  A61K49/00

    CPC分类号： C09B23/083 ,  A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K47/546 ,  A61K47/66 ,  B82Y5/00 ,  C09B47/045 ,  C09B47/30 ,  Y10S436/80 ,  Y10T436/13

    摘要： The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.

    摘要翻译： 本发明公开了用于双光疗法和组合治疗和诊断肿瘤和其他病变的化合物和组合物。 化合物具有染料，当光活化时，它们通过I型和/或II型机制进行操作。 其它染料或叠氮化物组分可以通过相同或不同的机理操作。 选择化合物中的特定组分以及组合物中化合物的配制允许不同的活化波长用于不同的疗法。 可以将靶向部分加入到化合物或组合物中，使得染料位于特定部位，例如激素敏感性肿瘤，用于诊断和/或治疗。 化合物和组合物可以掺入脂质体中。

    Topical aminolevulinic acid-photodynamic therapy for acne vulgaris
    45.
    发明公开
    Topical aminolevulinic acid-photodynamic therapy for acne vulgaris 审中-公开
    Topische光敏剂Therapie mitAminolävulinsäurefürAkne vulgaris

    公开(公告)号：EP2269645A2

    公开(公告)日：2011-01-05

    申请号：EP10180457.3

    申请日：2001-08-13

    申请人： The General Hospital Corporation doing business as Massachusetts General Hospital

    发明人： Anderson, Richard, Rox

    IPC分类号： A61K41/00 ,  A61K9/00

    CPC分类号： A61Q19/008 ,  A61K8/44 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/08 ,  A61K9/127 ,  A61K41/0061 ,  A61K2800/81 ,  A61Q19/00 ,  Y10S514/814

    摘要： Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.

    摘要翻译： 公开了用5-氨基乙酰丙酸和光动力疗法治疗皮脂腺疾病的轻度治疗。 优选的治疗包括将5-氨基乙酰丙酸局部施用于皮肤，然后以不同间隔重复治疗进行光照射。 在单次或多次治疗的低剂量ALA和光动力疗法（PDT）中，皮脂腺疾病例如痤疮的改善提供了发现皮脂分泌减少和消除细菌的发现。 在高剂量的ALA和单次高能量PDT治疗中，已经发现皮脂腺和皮脂分泌的永久性变化。

    Topical Aminolevulinic acid-photodynamic therapy for acne vulgaris
    46.
    发明公开
    Topical Aminolevulinic acid-photodynamic therapy for acne vulgaris 审中-公开
    泰利亚氨基酸荧光素酶治疗师FÜRAKNE VULGARIS

    公开(公告)号：EP2248536A3

    公开(公告)日：2010-12-08

    申请号：EP10003702.7

    申请日：2001-08-13

    申请人： The General Hospital Corporation doing business as Massachusetts General Hospital

    发明人： Anderson, Richard Cox

    IPC分类号： A61K41/00

    CPC分类号： H04N17/00 ,  A61K41/0061 ,  H04L12/2801 ,  H04L43/00

    摘要： Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.

    摘要翻译： 公开了用5-氨基乙酰丙酸和光动力疗法治疗皮脂腺疾病的轻度治疗。 优选的治疗包括将5-氨基乙酰丙酸局部施用于皮肤，然后以不同间隔重复治疗进行光照射。 在单次或多次治疗的低剂量ALA和光动力疗法（PDT）中，皮脂腺疾病例如痤疮的改善提供了发现皮脂分泌减少和消除细菌的发现。 在高剂量的ALA和单次高能量PDT治疗中，已经发现皮脂腺和皮脂分泌的永久性变化。

    A METHOD FOR NON-THERAPEUTIC OR THERAPEUTIC PHOTODYNAMIC SKIN TREATMENT
    49.
    发明公开
    A METHOD FOR NON-THERAPEUTIC OR THERAPEUTIC PHOTODYNAMIC SKIN TREATMENT 无效
    液体光敏剂用于光动力治疗皮肤治疗和非治疗光动力治疗皮肤使用

    公开(公告)号：EP2131862A1

    公开(公告)日：2009-12-16

    申请号：EP08715610.5

    申请日：2008-03-06

    申请人： Christiansen, Kåre ,  Bjerring, Peter ,  Van Der Beek, Klaas

    发明人： Christiansen, Kåre ,  Bjerring, Peter ,  Van Der Beek, Klaas

    IPC分类号： A61K41/00 ,  A61P17/00 ,  A61P17/10 ,  A61K31/195 ,  A61K8/44 ,  A61Q19/08 ,  A61Q9/00

    CPC分类号： A61K8/44 ,  A61K41/0057 ,  A61K41/0061 ,  A61K41/0066 ,  A61K2800/81 ,  A61Q9/00 ,  A61Q19/08

    摘要： In a method for non-therapeutic or therapeutic photodynamic treatment of a skin target area, a photosensitizer fluid incorporating a photosensitizing agent or a precursor for a photosensitizing agent is delivered to the target area, the photosensitizing agent having at least one absorption wavelength in a wavelength range higher than 400 nm. The target area is then exposed to light energy in a range of wavelengths comprising at least one absorption wavelength of the photosensitizing agent, the light energy being supplied to the target area in the form of at least one light pulse producing in the target area an accumulated energy density sufficient for photodynamic activation of the photosensitizing agent. The photosensitizing agent or precursor is incorporated in the photosensitizer fluid with a concentration in the range from 0.1 to 2.0 % preferably from 0.1 to 0.9 %, and the photosensitizer fluid is delivered to the target area in the form of a number of repeated spray doses during an overall delivery time ranging from 0.25 to 8 hours. The method can be applied to cosmetic treatments for skin rejuvenation, reduction of wrinkles, treatment of telangiectasia or removal of hair as wells a medical treatment of dermatologic diseases such as acne vulgaris, acne scars, rosacea, psorieasis, actinic keratoses, basal cell carcinoma, Bowen's disease or eczema.

    5-AMINOLEVULINIC ACID SALTS AND THEIR USE
    50.
    发明公开
    5-AMINOLEVULINIC ACID SALTS AND THEIR USE 审中-公开
    5-氨基乙酰乙酸盐及其用途

    公开(公告)号：EP2007711A1

    公开(公告)日：2008-12-31

    申请号：EP07736127.7

    申请日：2007-03-22

    申请人： BAR ILAN UNIVERSITY ,  Syneron Medical Ltd.

    发明人： MALIK, Zvi ,  NUDELMAN, Abraham

    IPC分类号： C07C229/22 ,  A61K31/22 ,  A61P35/04 ,  A61Q9/00 ,  A61K8/44

    CPC分类号： C07C309/35 ,  A61K8/44 ,  A61K41/0061 ,  A61Q19/00 ,  C07C53/126 ,  C07C229/22 ,  C07C309/29

    摘要： The invention provides salts of 5-Aminolevulinic acid (ALA) of formula (I): wherein RY is an organic acid moiety; Y is selected from the group consisting of a sulfonic acid residue, mono- or di-phosphoric acid residue, mono- or di-carboxylic acid residue and R is selected from the group consisting of saturated, unsaturated, straight or branched C2-C20 chains, aryl, aralkyl or naphthyl. In preferred embodiments, RY is selected from benzenesulfonic acid (besylate), 2-naphthalene sulfonic acid (napsyate), p-toluenesulfonic acid (tosylate), diethyl phosphate, dibenzyl phosphate, di-(2-ethylhexyl) phosphate, caproic or stearic acids. The invention also provides methods for preparing the ALA salts of the invention, pharmaceutical compositions containing the ALA salts of the invention, and use of the ALA salts of the invention in photodynamic therapy (PDT).

    摘要翻译： 本发明提供了式（I）的5-氨基乙酰丙酸（ALA）的盐：其中RY是有机酸部分; Y选自磺酸残基，单磷酸残基或二磷酸残基，单羧酸残基或二羧酸残基，R选自饱和的，不饱和的，直链或支链的C2-C20链 ，芳基，芳烷基或萘基。 在优选的实施方案中，RY选自苯磺酸（苯磺酸盐），2-萘磺酸（萘磺酸盐），对甲苯磺酸（甲苯磺酸盐），磷酸二乙酯，磷酸二苄酯，磷酸二 - （2-乙基己基）酯，己酸或硬脂酸 。 本发明还提供了用于制备本发明的ALA盐的方法，含有本发明的ALA盐的药物组合物，以及本发明的ALA盐在光动力治疗（PDT）中的用途。