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    NEOADJUVANT THERAPY FOR BLADDER CANCER
    2.
    发明公开
    NEOADJUVANT THERAPY FOR BLADDER CANCER 审中-公开

    公开(公告)号：EP3389717A1

    公开(公告)日：2018-10-24

    申请号：EP16819894.3

    申请日：2016-12-19

    申请人： Photocure ASA

    发明人： HESTDAL, Kjetil

    IPC分类号： A61K41/00 ,  A61P35/00

    CPC分类号： A61K41/0061

    摘要： This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.

    Photodynamic diagnostics of tissue fluids caused by oncological pathology
    10.
    发明公开
    Photodynamic diagnostics of tissue fluids caused by oncological pathology 有权
    组织的光动力诊断为流体肿瘤学病理

    公开(公告)号：EP2722059A3

    公开(公告)日：2014-08-27

    申请号：EP13189606.0

    申请日：2013-10-22

    申请人： I.I. Lazeriu ir Bangu Medicinos Moksline Klinika ,  Lietuvos Edukologijos Universitetas

    发明人： Plesniene, Laima ,  Plesnys, Albinas ,  Vaisnoras, Rimantas

    IPC分类号： A61K49/00 ,  G01N33/574

    CPC分类号： A61K41/0061 ,  A61K41/0071 ,  A61K49/0036 ,  G01N33/574

    摘要： The invention is related to biomedicine in particular to diagnostics of oncological pathology conditioned tissue fluids.
    Neoplastic process often causes discharge of tissue liquids and their subsequent accumulation in various cavities of a body, most often in pleura and peritoneum. Treatment of patients, suffering from accumulation of tissue liquids caused by neoplastic process, is substantially different from treatment of cases of accumulation of tissue liquids caused by other conditions. Therefore for clinicians it is crucial to perform accurate and timely diagnostics of tissue liquids caused by pleural malignant ascites and other neoplastic pathologies.
    This invention provides a diagnostic system, comprising puncturing of an adequate volume of liquid accumulated in a tissue, when patient undergoing said test, prior to puncturing of said tissue liquid, with intent for treatment and/or diagnostics is administered with an adequate photosensitizer or its precursor, illuminating collected tissue liquid with a light (violet) having certain wavelength, whereat a color and intensity of the glow of said liquid is assessed visually or by spectrophotometric methods. Derivatives of hematoporphyrine, such as photofrin, photohem, photosan, which are illuminated with 400 - 405 nm wavelengths light, are used in the invention; the raspberry-color glow of a test liquid is assessed visually or by using a spectrophotometer.