Verfahren und Vorrichtung zur Bestimmung des Volumens einer Flüssigkeitsprobe
    42.
    发明公开
    Verfahren und Vorrichtung zur Bestimmung des Volumens einer Flüssigkeitsprobe 有权
    一种用于确定液体样品的体积的方法和装置

    公开(公告)号:EP1221341A1

    公开(公告)日:2002-07-10

    申请号:EP01125832.4

    申请日:2001-10-30

    申请人: Tecan Trading AG

    摘要: Die Erfindung betrifft ein Verfahren, eine Vorrichtung und ein Testkit zur Durchführung dieses Verfahrens zur Bestimmung des Volumens einer Probe einer Flüssigkeit (A). Bei dem Verfahren wird - zum Anfärben der Flüssigkeit (A) - eine bestimmte Konzentration eines chromophoren Indikators in dieser Flüssigkeit (A) erstellt, eine Probe von der Flüssigkeit (A) abgetrennt, die optische Absorption der abgetrennten Probe gemessen und das Volumen der abgetrennten Probe durch Korrelation der gemessenen optischen Absorption mit der Konzentration des Indikators in dieser Flüssigkeit (A) bestimmt. Das Verfahren ist dadurch gekennzeichnet, dass als Indikator zum Anfärben der Flüssigkeit (A) Ionen verwendet werden, welche durch Komplexierung mit einem spezifischen Liganden die Färbung der Probe erzeugen.

    摘要翻译: 本发明涉及一种方法,装置和检测试剂盒,用于测定液体(A)的样品的体积进行该方法。 一个发色团指示在该液体中的一定浓度的(A),所创建的液体(A)的样品,分离,所述分离的样品的光学吸收进行测量,并将分离的样品的体积 - 在该方法中 - 用于着色液体(A) 通过以在该液体(A)的指示剂的浓度测得的光学吸收的相关性。 该方法的特征在于,(A),离子所使用的作为用于着色液体,其通过络合产生与特异性配体,所述样品的染色的指示器。

    METHOD AND DEVICE FOR INJECTING A FIXED QUANTITY OF LIQUID
    43.
    发明公开
    METHOD AND DEVICE FOR INJECTING A FIXED QUANTITY OF LIQUID 有权
    方法和装置液体注入指定数量的

    公开(公告)号:EP1155748A1

    公开(公告)日:2001-11-21

    申请号:EP99959878.2

    申请日:1999-12-17

    摘要: The present invention is intended to provide a method and apparatus with which, when ejecting or applying a very small amount of liquid, the liquid can be applied in a desired form at a high speed and precisely without depending on viscosity of the liquid.
    In a fixed-amount-of-liquid ejecting method according to the present invention, for ejecting a liquid in fixed amount from a liquid reservoir through an ejection valve, the method comprises a step of applying a pressure to the liquid beforehand prior to starting ejection of the liquid and/or holding a pressure near an ejection orifice after the end of liquid ejection at a predetermined specific value so that an ejection rate of the liquid through the ejection orifice is kept constant. Other features are that a liquid temperature is controlled, and/or that the liquid is automatically filled without entrapment of bubbles.
    A fixed-amount-of-liquid ejecting apparatus according to the present invention comprises a liquid reservoir, means for pressurizing a liquid in the liquid reservoir, and an ejection valve communicating with the liquid reservoir, thereby ejecting the liquid in fixed amount from the liquid reservoir through the ejection valve. The apparatus further comprises operation control means for controlling operations of the pressurizing means and the ejection valve, and ejection pressure control means for automatically regulating an ejection pressure of the liquid. The apparatus is further featured by including liquid temperature control means and/or a filling apparatus for automatically filling the liquid in the liquid reservoir without entrapment of bubbles.

    TOXICITY TYPING USING EMBRYOID BODIES
    45.
    发明公开
    TOXICITY TYPING USING EMBRYOID BODIES 审中-公开
    毒性由胚体打字

    公开(公告)号:EP1137809A1

    公开(公告)日:2001-10-04

    申请号:EP99963069.2

    申请日:1999-12-09

    申请人: Vistagen, Inc.

    摘要: This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian embryoid bodies contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions.

    VERFAHREN ZUR BESTIMMUNG VON PIPETTIERTEN FLÜSSIGKEITSVOLUMINA
    46.
    发明公开
    VERFAHREN ZUR BESTIMMUNG VON PIPETTIERTEN FLÜSSIGKEITSVOLUMINA 有权
    用于确定移液的液体体积

    公开(公告)号:EP1062483A1

    公开(公告)日:2000-12-27

    申请号:EP99911785.6

    申请日:1999-03-12

    申请人: QIAGEN GmbH

    发明人: LUTZE, Konstantin

    IPC分类号: G01F17/00 G01N35/10 G01F13/00

    CPC分类号: G01N35/1016 G01F17/00

    摘要: The invention relates to a method for determining a pipetted volume of liquid, according to which the liquid is withdrawn from a vessel by means of a pipette or transferred from a pipette into a vessel. The invention relates especially to a method according to which in a first step the liquid volume V1a present in a vessel is determined by means of a detection device, after which a liquid volume V1ist is taken up by a pipette and the liquid volume V1e contained in the vessel is again determined. Thereafter the liquid volume V1ist actually taken up is calculated using the equation V1a - V1e = V1ist. Next the difference between the liquid volume V1ist actually taken up and a liquid volume V1soll intended for uptake is calculated on the basis of the equation |V1ist - V1soll| = V1diff, after which the difference V1diff is compared with a predetermined liquid volume ε1 and an error message is displayed if V1diff > ε1.

    MEASUREMENT OF QUANTITY OF INCOMPRESSIBLE SUBSTANCE IN A CLOSED CONTAINER
    48.
    发明公开
    MEASUREMENT OF QUANTITY OF INCOMPRESSIBLE SUBSTANCE IN A CLOSED CONTAINER 失效
    量的测量不可压缩的物质在密闭的容器

    公开(公告)号:EP0986740A1

    公开(公告)日:2000-03-22

    申请号:EP98926035.1

    申请日:1998-05-14

    IPC分类号: G01F17/00

    CPC分类号: G01F17/00 G01F23/14

    摘要: In a process and apparatus for delivering a processing substance from a storage vessel to a processing station, the storage vessel enclosing a processing substance storage space and being coupled to conduits which communicate with the storage space, the storage vessel and the conduits enclosing a volume which includes the storage space, a method and system for determining the quantity of processing substance in the storage space by: closing the volume enclosed by the storage vessel and the conduits; performing first and second pressure measurements for measuring the gas pressure in the volume when the volume contains respectively first and second quantities of gas; determining the difference between the first and second quantities of gas; and calculating the quantity of processing substance in the storage space on the basis of the volume, the difference between the first and second quantities of gas and the gas pressures measured during the first and second pressure measurements.

    METHOD AND APPARATUS FOR BODY VOLUME MEASURING
    49.
    发明公开
    METHOD AND APPARATUS FOR BODY VOLUME MEASURING 失效
    体积测量方法和装置

    公开(公告)号:EP0538360A4

    公开(公告)日:1996-03-06

    申请号:EP91913188

    申请日:1991-07-08

    发明人: DEMPSTER PHILIP T

    CPC分类号: A61B5/4872 A61B5/1073

    摘要: Method and apparatus for volume measurement and body composition estimation provides an accurate, non-invasive estimation of the body volume and body composition of an object or body such as a human being. The present invention provides a first chamber (2) with a door (9) or closable means of entry through which an object or a subject may enter, along with a second chamber (3) and means (18) to cyclically perturb the volumes of the two chambers in a precisely complementary fashion. The present invention also measures the pressure in each of the chambers, controls in real time the volume perturbation and analyzes the pressure records so as to yield volume and body composition estimations.