公开(公告)号：EP2144910A2

公开(公告)日：2010-01-20

申请号：EP08737800.6

申请日：2008-04-11

申请人： Actelion Pharmaceuticals Ltd.

发明人： BUR, Daniel ,  HUBSCHWERLEN, Christian ,  RUEEDI, Georg ,  SURIVET, Jean-Philippe ,  ZUMBRUNN ACKLIN, Cornelia

IPC分类号： C07D471/04 ,  A61K31/435 ,  A61P31/00 ,  C07D519/00

CPC分类号： C07D413/14 ,  C07D471/04 ,  C07D519/00

摘要： The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. Certain compounds of formula (I) are new and are also part of this invention.

摘要翻译： 本发明涉及式（I）化合物，其中U，V，W，X，R1，R2，R3，R4，R5，R6，A，B，D，E，G，m和n如说明书 涉及这些化合物的药学上可接受的盐，用于制造用于预防或治疗细菌感染的药物。 某些式（I）化合物是新的并且也是本发明的一部分。

公开(公告)号：EP2125760A2

公开(公告)日：2009-12-02

申请号：EP08719826.3

申请日：2008-03-25

申请人： Actelion Pharmaceuticals Ltd.

发明人： AISSAOUI, Hamed ,  BOSS, Christoph ,  GUDE, Markus ,  KOBERSTEIN, Ralf ,  SIFFERLEN, Thierry

IPC分类号： C07D277/04 ,  C07D277/24 ,  C07D277/56 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/427 ,  A61P25/00 ,  A61P25/28 ,  A61P9/00

CPC分类号： C07D417/14 ,  C07D277/04 ,  C07D277/24 ,  C07D277/56 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04

摘要： The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

公开(公告)号：EP1322624B1

公开(公告)日：2009-10-21

申请号：EP01980288.3

申请日：2001-08-28

申请人： Actelion Pharmaceuticals Ltd.

发明人： WELLER, Thomas ,  BOLLI, Martin ,  BOSS, Christoph ,  CLOZEL, Martine ,  Fischli, Walter

IPC分类号： C07D239/46 ,  A61K31/505 ,  A61P9/10 ,  C07D409/14

摘要： The invention relates to novel aryl-alkane-sulfonamides of the general formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

公开(公告)号：EP2094690A2

公开(公告)日：2009-09-02

申请号：EP07859531.1

申请日：2007-12-28

申请人： Actelion Pharmaceuticals Ltd.

发明人： AISSAOUI, Hamed ,  BOSS, Christoph ,  GUDE, Markus ,  KOBERSTEIN, Ralf ,  SIFFERLEN, Thierry ,  TRACHSEL, Daniel

IPC分类号： C07D407/12 ,  C07D407/14 ,  C07D417/14 ,  C07D513/04 ,  A61K31/427 ,  A61P25/00

CPC分类号： C07D513/04 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14

摘要： The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

公开(公告)号：EP2086968A1

公开(公告)日：2009-08-12

申请号：EP07827038.6

申请日：2007-11-09

申请人： Actelion Pharmaceuticals Ltd.

发明人： HUBSCHWERLEN, Christian ,  PANCHAUD, Philippe ,  SPECKLIN, Jean-Luc

IPC分类号： C07D413/14 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61P31/00

CPC分类号： C07D413/14 ,  C07D471/04

摘要： The invention relates to novel chimeric antibiotics of formula (I) wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; R3 represents H or fluorine; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R6 represents H, alkoxy or halogen; and n is O or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula (I). These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).

公开(公告)号：EP2079690A2

公开(公告)日：2009-07-22

申请号：EP07826577.4

申请日：2007-09-28

申请人： Actelion Pharmaceuticals Ltd.

发明人： AISSAOUI, Hamed ,  BOSS, Christoph ,  GUDE, Markus ,  KOBERSTEIN, Ralf ,  LEHMANN, David ,  SIFFERLEN, Thierry ,  TRACHSEL, Daniel

IPC分类号： C07D209/52 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/403 ,  A61P25/00

CPC分类号： C07D409/12 ,  C07D209/52 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

摘要翻译： 本发明涉及式（I）的3-氮杂 - 双环[3.1.0]己烷衍生物，其中A，B，n，X和R1如说明书中所述，及其盐，以及它们作为食欲肽受体拮抗剂 。

公开(公告)号：EP2069332A2

公开(公告)日：2009-06-17

申请号：EP07826034.6

申请日：2007-08-15

申请人： Actelion Pharmaceuticals Ltd.

发明人： AISSAOUI, Hamed ,  BOSS, Christoph ,  GUDE, Markus ,  KOBERSTEIN, Ralf ,  SIFFERLEN, Thierry

IPC分类号： C07D405/12 ,  C07D417/14 ,  C07D515/04 ,  A61K31/397 ,  A61P25/00

CPC分类号： C07D405/12 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04 ,  C08L19/006 ,  C08L21/00 ,  C08L83/10 ,  C08L2666/08 ,  C08L2666/04

摘要： The invention relates to novel azetidine compounds of formula (I),wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

公开(公告)号：EP2059246A2

公开(公告)日：2009-05-20

申请号：EP07826167.4

申请日：2007-08-28

申请人： Actelion Pharmaceuticals Ltd.

发明人： CLOZEL, Martine

IPC分类号： A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  A61P9/00

CPC分类号： A61K31/513 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having PDE5-inhibitory properties, or a pharmaceutically acceptable salt thereof, for therapeutic use, simultaneously, separately or over a period of time, in the treatment of a disease wherein vasoconstriction is involved.

公开(公告)号：EP2051962A1

公开(公告)日：2009-04-29

申请号：EP07805287.5

申请日：2007-08-02

申请人： Actelion Pharmaceuticals Ltd.

发明人： FRETZ, Heinz ,  POTHIER, Julien ,  RISCH, Philippe

IPC分类号： C07D209/88

CPC分类号： C07D209/88

摘要： The present invention relates to (3-amino-l,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

公开(公告)号：EP1998774A1

公开(公告)日：2008-12-10

申请号：EP07735108.8

申请日：2007-03-14

申请人： Actelion Pharmaceuticals Ltd.

发明人： JENCK, François

IPC分类号： A61K31/47 ,  A61P25/28

CPC分类号： A61K31/47

摘要： The invention relates to the use of tetrahydroisoquinoline derivatives for the preparation of a medicament to enhance, maintain and/or restore all stages and/or types of short-, middle- and/or long-term memory.