公开(公告)号：EP0822812A4

公开(公告)日：2000-06-14

申请号：EP96910472

申请日：1996-03-18

申请人： PERRICONE NICHOLAS V

发明人： PERRICONE NICHOLAS V

IPC分类号： A61K31/131 ,  A61K31/137 ,  A61K31/14 ,  A61K31/198 ,  A61K31/216 ,  A61K31/221 ,  A61K31/4045 ,  A61K45/06 ,  A61P17/00 ,  A61P21/00 ,  A61P21/04 ,  A61K31/195 ,  A61K31/13 ,  A61K31/135 ,  A61K31/40

CPC分类号： A61K31/221 ,  A61K31/131 ,  A61K31/137 ,  A61K31/14 ,  A61K31/198 ,  A61K31/216 ,  A61K31/4045 ,  A61K45/06 ,  Y10S424/05 ,  Y10S514/944

摘要： Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue containing catecholamines and/or acetylcholine precursors in a dermatologically acceptable carrier. Catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Acetylcholine precursors include dimethylaminoethanol, monoaminoethanol, choline, serine, and mixtures thereof. Preferred embodiments further contain at least one other ingredient that enhances skin penetration. In these and other embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, other cofactors such as vitamin B6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added; a fatty acid ester of ascorbic acid is included in some formulations.

摘要翻译： 下垂皮下肌肉和覆盖皮肤组织的局部治疗组合物含有皮肤可接受的载体儿茶酚胺和/或相关化合物。 实施例一儿茶酚胺包括肾上腺素，去甲肾上腺素，多巴胺及其前体; 儿茶酚胺前体：如酪氨酸和苯丙氨酸是优选的。 优选实施例的进一步包含至少一种其它成分没有增强神经递质合成和/或皮肤渗透。 在一些实施方案中，在乙酰胆碱前体：例如二甲基氨基乙醇和/或抗坏血酸的脂肪酸酯都包含在制剂中。 在论文和其它实施例，特别是那些采用酪氨酸和/或苯丙氨酸作为儿茶酚胺前体，辅因子等：例如维生素B6和泛酸或泛酸钙被包括在组合物中以提高活性成分的作用。 其他化合物并清除自由基，因此可以添加抗氧化剂。

公开(公告)号：EP0801565A1

公开(公告)日：1997-10-22

申请号：EP95914884.0

申请日：1995-03-27

申请人： PERRICONE, Nicholas V

发明人： PERRICONE, Nicholas V

IPC分类号： A61K8 ,  A61K31 ,  A61Q5 ,  A61Q17 ,  A61Q19

CPC分类号： A61Q19/08 ,  A61K8/498 ,  A61K8/676 ,  A61K8/678 ,  A61K31/35 ,  A61K31/355 ,  A61K31/60 ,  A61Q5/00 ,  A61Q17/04 ,  Y10S514/847 ,  A61K2300/00

摘要： A method for the prevention and/or treatment of skin or hair damage, particularly inflammation and aging of skin and hair damage from sunlight and chemicals, in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin or hair areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier.

公开(公告)号：EP0295300A4

公开(公告)日：1989-06-21

申请号：EP88901752

申请日：1987-12-21

申请人： PERRICONE NICHOLAS V

发明人： PERRICONE NICHOLAS V

IPC分类号： A61K20060101 ,  A61K8/365 ,  A61K31/19 ,  A61K31/215 ,  A61Q9/02 ,  C11D20060101 ,  A61K7/15

CPC分类号： A61K8/365 ,  A61Q9/02

摘要： Treatment and prevention of pseudofolliculitis barbae (''razor bumps'') is effected by topical application to beard areas of an alpha-hydroxy acid or derivative thereof, most preferably glycolic acid or glycolic acid derivatives, and most preferably as a component of a cosmetically acceptable lotion, cream, ointment, soap, shaving foam, stick, gel or solution.