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    PR13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES
    54.
    发明公开
    PR13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES 审中-公开

    公开(公告)号：EP3778904A1

    公开(公告)日：2021-02-17

    申请号：EP20172647.8

    申请日：2013-10-28

    申请人： Bavarian Nordic A/S

    发明人： Steigerwald, Robin ,  Brinkmann, Kay

    IPC分类号： C12N15/863 ,  A61K39/00 ,  A61P37/04 ,  A61P43/00

    摘要： The invention encompasses recombinant poxviruses, preferably modified Vaccinia Ankara (MVA) viruses, comprising a Pr13.5 promoter operably linked to a nucleotide sequence encoding an antigen and uses thereof. The invention is drawn to compositions and methods for the induction of strong CD8 T cell and antibody responses to a specific antigen(s) by administering one or more immunizations of the recombinant MVA to a mammal, preferably a human.

    METHODS AND COMPOSITIONS FOR ENHANCING VACCINE IMMUNE RESPONSES
    58.
    发明公开
    METHODS AND COMPOSITIONS FOR ENHANCING VACCINE IMMUNE RESPONSES 审中-公开

    公开(公告)号：EP3639851A1

    公开(公告)日：2020-04-22

    申请号：EP19164313.9

    申请日：2013-03-15

    申请人： Bavarian Nordic A/S

    发明人： Lauterbach, Henning ,  Hochrein, Hubertus

    IPC分类号： A61K39/12 ,  A61K39/00

    摘要： Provided herein are immunogenic compositions comprising a recombinant modified vaccinia virus Ankara (MVA) comprising a nucleic acid sequence encoding a CD40 ligand (CD40L) and a nucleic acid sequence encoding a heterologous disease-associated antigen, wherein the immunogenic composition induces increases T-cell immune responses specific for the heterologous disease-associated antigen when administered to a human host, and related methods and uses.