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51.发明公开
公开(公告)号：EP3416980A1
公开(公告)日：2018-12-26
申请号：EP17705891.4
申请日：2017-02-17
发明人： SCHOOR, Oliver , MAHR, Andrea , WEINSCHENK, Toni , WIEBE, Anita , FRITSCHE, Jens , SINGH, Harpreet
IPC分类号： C07K14/47
CPC分类号： A61K39/0011 , A61K2039/5158 , C07K14/4748 , C07K14/705 , C07K14/7051 , C07K14/70539 , C07K16/30 , C07K2319/33 , C12N5/0638 , C12N15/115 , C12N2310/16 , C12N2501/50 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57492
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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52.发明公开
公开(公告)号：EP3331900A2
公开(公告)日：2018-06-13
申请号：EP16750766.4
申请日：2016-08-05
发明人： MAHR, Andrea , WEINSCHENK, Toni , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet , MÜLLER, Phillip , LEIBOLD, Julia , GOLDFINGER, Valentina
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5158 , A61K2039/572 , C07K14/47 , C07K14/4748 , C07K14/7051 , C07K16/30 , C07K2319/00 , C12N5/0636 , C12N15/115 , C12N2310/16 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G01N33/5748 , G01N33/6848 , G01N2570/00 , G01N2800/52
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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53.发明公开
公开(公告)号：EP3325498A1
公开(公告)日：2018-05-30
申请号：EP16805839.4
申请日：2016-12-05
发明人： MAHR, Andrea , WEINSCHENK, Toni , SONG, Colette , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/00 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K14/7051 , C07K14/71 , C07K14/721 , C07K14/8135 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/2869 , C07K16/30 , C07K16/38 , C07K16/40 , C07K2317/34 , C07K2317/76 , C07K2319/40 , C12N5/0636 , C12N5/0638 , C12N9/0091 , C12N9/1264 , C12N15/115 , C12N2310/16 , C12N2502/11 , C12Q1/6886 , C12Q2600/156 , C12Y116/01 , C12Y207/07031 , G01N33/57484 , G01N2333/47 , G06F19/20
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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54.发明公开PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AND METHODS FOR GENERATING SCAFFOLDS FOR THE USE AGAINST PANCREATIC CANCER AND OTHER CANCERS 审中-公开用于免疫治疗的肽和用于产生用于胰腺癌和其他癌症的用途的方法的肽的组合和肽的组合
公开(公告)号：EP3310806A2
公开(公告)日：2018-04-25
申请号：EP16736799.4
申请日：2016-06-17
CPC分类号： C07K14/4748
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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55.发明授权METHOD FOR DIFFERENTIALLY QUANTIFYING NATURALLY PROCESSED HLA-RESTRICTED PEPTIDES FOR CANCER, AUTOIMMUNE AND INFECTIOUS DISEASES IMMUNOTHERAPY DEVELOPMENT 有权用于区分自然加工的HLA限制性肽用于癌症，自身免疫和感染性疾病免疫治疗发展的方法
公开(公告)号：EP2558867B1
公开(公告)日：2017-12-06
申请号：EP11714563.1
申请日：2011-04-15
发明人： WEINSCHENK, Toni , FRITSCHE, Jens
IPC分类号： G01N33/68
CPC分类号： G01N33/56977 , G01N33/6842 , G01N33/6848 , G01N33/6878 , G01N2333/70539 , Y02A90/24
摘要： The invention relates to a method for quantitatively identifying relevant HLA-bound peptide antigens from primary tissue specimens on a large scale without labeling approaches. This method can not only be used for the development of peptide vaccines, but is also highly valuable for a molecularly defined immunomonitoring and the identification of new antigens for any immunotherapeutic strategy in which HLA-restricted antigenic determinants function as targets, such as a variety of subunit vaccines or adoptive T-cell transfer approaches in cancer, or infectious and autoimmune diseases.
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56.发明授权
公开(公告)号：EP2178557B1
公开(公告)日：2017-03-01
申请号：EP08785105.1
申请日：2008-07-25
发明人： SINGH, Harpreet , SCHOOR, Oliver , TRAUTWEIN, Claudia , HILF, Norbert , WEINSCHENK, Toni , WALTER, Steffen , LEWANDROWSKI, Peter
CPC分类号： A61K39/0011 , A61K38/193 , A61K45/06 , A61K2039/5158 , A61K2039/53 , A61K2039/572 , C07K14/4748 , A61K2300/00
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumour immune responses against colorectal cancer.
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57.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 审中-公开新型免疫疗法针对不同肿瘤，包括神经和脑肿瘤
公开(公告)号：EP3120869A1
公开(公告)日：2017-01-25
申请号：EP16179192.6
申请日：2009-09-28
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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58.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 审中-公开新型免疫治疗包括神经元和脑肿瘤在内的多种肿瘤
公开(公告)号：EP3120868A1
公开(公告)日：2017-01-25
申请号：EP16179174.4
申请日：2009-09-28
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 具体而言，本发明涉及癌症的免疫治疗。 本发明还涉及单独或与其他肿瘤相关肽组合的肿瘤相关的细胞毒性T细胞（CTL）肽表位，所述肽用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分。 本发明涉及30种肽序列及其衍生自可用于引发抗肿瘤免疫应答的疫苗组合物的人类肿瘤细胞的HLA I类和II类分子的肽序列及其变体。
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59.发明授权
公开(公告)号：EP2643698B1
公开(公告)日：2016-06-22
申请号：EP11788121.9
申请日：2011-11-22
IPC分类号： G01N33/574 , A61K39/00
CPC分类号： G01N33/57488 , G01N33/5011 , G01N33/574 , G01N2333/523 , G01N2333/775 , G01N2800/52
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公开(公告)号：EP2183361B1
公开(公告)日：2015-06-10
申请号：EP08785107.7
申请日：2008-07-25
发明人： SCHOOR, Oliver , HILF, Norbert , WEINSCHENK, Toni , TRAUTWEIN, Claudia , WALTER, Steffen , SINGH, Harpreet
CPC分类号： A61K35/17 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C12N5/0638
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