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51.发明公开
公开(公告)号：EP1296915A1
公开(公告)日：2003-04-02
申请号：EP01933970.4
申请日：2001-05-16
申请人： MERCK PATENT GmbH
CPC分类号： C07B37/00 , B01J19/0093 , B01J2219/00984 , C07C1/2072
摘要： The invention relates to a method for transferring alkylidene groups to organic compounds. According to the inventive method, at least one organic compound in a liquid or dissolved from is mixed with at least one alkylidene group transfer reagent in a liquid or dissolved form in at least one microreactor, reacted during a specific reaction time and the olefin thus obtained is, optionally, isolated from the reaction mixture.
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公开(公告)号：EP1284965A1
公开(公告)日：2003-02-26
申请号：EP01943202.0
申请日：2001-03-29
申请人： MERCK PATENT GmbH
IPC分类号： C07D209/88 , B01J19/00 , C07B37/10
CPC分类号： B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00916 , B01J2219/00984 , C07D209/88
摘要： The invention relates to a method for producing indols, characterized in that at least one aryl hydrazone in liquid or dissolved form is mixed with at least one catalyst in liquid or dissolved form in an optionally temperable microreactor and reacted for a residence time, before the resulting indol compound is optionally isolated from the reaction mixture.
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53.发明公开
公开(公告)号：EP1272482A1
公开(公告)日：2003-01-08
申请号：EP01923597.7
申请日：2001-02-22
申请人： MERCK PATENT GmbH
IPC分类号： C07D313/04 , C07B41/08 , C07B41/12
CPC分类号： C07D315/00 , C07B41/12
摘要： The invention relates to a method for carrying out a Baeyer-Villiger oxidation of organic carbonyl compounds.
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54.发明公开VERFAHREN ZUR 1,3-DIPOLAREN CYCLOADDITION ORGANISCHER VERBINDUNGEN IN EINEM MIKROREAKTOR 审中-公开方法1.3偶极环有机化合物在微反应器
公开(公告)号：EP1268485A1
公开(公告)日：2003-01-02
申请号：EP01917070.3
申请日：2001-03-06
申请人： MERCK PATENT GmbH
IPC分类号： C07D498/04 , C07B37/10
CPC分类号： C07D498/04 , B01J19/0093 , C07B37/10
摘要： The invention relates to a method for the 1,3 dipolar cycloaddition of organic compounds, characterised in that the reaction is carried out in a microreactor.
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55.发明公开VERFAHREN ZUR OXIMIERUNG ORGANISCHER CARBONYLVERBINDUNGEN UND/ODER CH/ACIDER VERBINDUNGEN 审中-公开VERFAHREN ZUR OIMIMIERUNG组织机构CARBONYLVERBINDUNGEN UND / ODER CH / ACIDER VERBINDUNGEN
公开(公告)号：EP1268406A1
公开(公告)日：2003-01-02
申请号：EP01915317.0
申请日：2001-03-06
申请人： MERCK PATENT GmbH
IPC分类号： C07C249/08 , C07C249/06 , C07C251/48 , B01J19/00
CPC分类号： C07D498/04 , B01J19/0093 , B01J2219/00984 , C07C249/08 , C07C251/48
摘要： The invention relates to a method for oximating organic carbonyl compounds and/or CH-acid compounds, wherein at least one organic carbonyl compound and/or CH-acid compound in a liquid or dissolved form is mixed with at least one oximating agent in a liquid or dissolved form in at least one microreactor, is reacted during a residence time and the organic oxime thus formed is optionally isolated from the reaction mixture.
摘要翻译： 本发明涉及一种肟化有机羰基化合物和/或CH-酸化合物的方法，其中将液体或溶解形式的至少一种有机羰基化合物和/或CH-酸化合物与液体中的至少一种肟化剂混合 或溶解形式在至少一个微反应器中，在停留时间内反应，并且任选地从反应混合物中分离出由此形成的有机肟。
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公开(公告)号：EP1200375A2
公开(公告)日：2002-05-02
申请号：EP00947931.2
申请日：2000-07-05
申请人： MERCK PATENT GmbH
IPC分类号： C07B43/02 , C07C201/08 , C07D217/02 , C07D307/77
CPC分类号： B01J19/0093 , B01J2219/00889 , C07B43/02 , C07C201/08 , C07D217/02 , C07D217/04 , C07C205/06
摘要： The invention relates to a novel method for the nitration of organic compounds, preferably of aromatics and heteroaromatics, using known and novel types of nitration reagents.
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57.发明公开IMIDAZOL[4,5-C-]-PYRIDIN-4-ON-DERIVATE MIT FAKTOR XA HEMMENDER WIRKUNG 审中-公开IMIDAZOL¬4,5-C - 吡啶-4- ON用Xa因子抑制作用衍生物
公开(公告)号：EP1117664A1
公开(公告)日：2001-07-25
申请号：EP99946151.0
申请日：1999-09-09
申请人： MERCK PATENT GmbH
发明人： GANTE, Joachim , MEDERSKI, Werner , JURASZYK, Horst , WURZIGER, Hanns , DORSCH, Dieter , BUCHSTALLER, Hans-Peter , BERNOTAT-DANIELOWSKI, Sabine , MELZER, Guido , ANZALI, Soheila
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： The invention relates to novel compounds of formula (I), wherein R, R?1, R2, R3¿, n and p have the meaning defined in claim 1. Said compounds are inhibitors of clotting factor Xa and can be used for the prophylaxis and/or therapy of thrombo-embolic disorders.
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公开(公告)号：EP1107954A1
公开(公告)日：2001-06-20
申请号：EP99936606.5
申请日：1999-07-26
申请人： MERCK PATENT GmbH
发明人： GANTE, Joachim DI , JURASZYK, Horst , WURZIGER, Hanns , DORSCH, Dieter , BUCHSTALLER, Hans-Peter , BERNOTAT-DANIELOWSKI, Sabine , MELZER, Guido , ANZALI, Soheila , MEDERSKI, Werner
IPC分类号： C07D215/22 , C07D215/50 , C07D413/12 , C07D413/14 , A61K31/47
CPC分类号： C07D215/227 , C07D215/50 , C07D215/54 , C07D413/10 , C07D413/14
摘要： The invention relates to novel compounds of formula (I), wherein X, Y, R, R?1, R2, R3¿ and n have the meaning cited in patent claim 1. Said compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases.
摘要翻译： 本发明涉及式（I）的新化合物，其中X，Y，R，R 1，R 2，R 3和n具有权利要求1中引用的含义。所述化合物是凝血因子Xa的抑制剂并且可以使用 用于预防和/或治疗血栓栓塞性疾病。
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