公开(公告)号：EP2004258A1

公开(公告)日：2008-12-24

申请号：EP06753388.5

申请日：2006-04-13

申请人： Boehringer Ingelheim Microparts Gmbh

发明人： DUNNE, Stephen, Terence

IPC分类号： A61M11/02 ,  A61M15/00

CPC分类号： A61M11/02 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0028 ,  A61M15/0036 ,  A61M15/0045 ,  A61M15/0048 ,  A61M2202/064 ,  A61M2205/071 ,  A61M2205/8218 ,  A61M2206/16

摘要： A dispensing device (1) for dispensing powder (2) as a spray (3) is disclosed. The dispensing device comprises a duct (5) through which the powder is dispensible by gas pressure for de-agglomerating the powder. The duct is angled by at least about 90 degrees at a diversion portion (12) and/or diverted into two opposite directions at a fork portion (15) so that the powder is impacted on to a solid surface (14) for powder de-agglomeration.

摘要翻译： 公开了一种用于分配作为喷雾（3）的粉末（2）的分配装置（1）。 分配装置包括管道（5），通过该管道可以通过气体压力分配粉末以使粉末解聚。 所述管道在分流部分（12）处成角度至少约90度和/或在叉部分（15）处被转向到两个相反方向，使得所述粉末被冲击到固体表面（14） 结块。

公开(公告)号：EP1992380A1

公开(公告)日：2008-11-19

申请号：EP07009804.1

申请日：2007-05-16

申请人： Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： Rohrschneider, Marc ,  Dunne, Stephen T.

IPC分类号： A61M15/00

CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M15/0003 ,  A61M15/0031 ,  A61M15/0036 ,  A61M15/0048 ,  A61M15/0061 ,  A61M15/0075 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/8225

摘要： A dispensing device (1) having a storage device (4) and an air pump (18) for dispensing a medical formulation is proposed. The storage device (4) comprises multiple inserts (6), each insert (6) containing a single dose of the formulation (2). Each insert (6) is located in a separate and sealed cavity (7). The cavities (7) can be individually opened for dispensing the respective dose from the respective insert (6).

摘要翻译： 提出了一种具有用于分配药物制剂的储存装置（4）和空气泵（18）的分配装置（1）。 存储装置（4）包括多个插入件（6），每个插入件（6）包含单剂量的制剂（2）。 每个插入件（6）位于分开且密封的空腔（7）中。 空腔（7）可以单独打开以从相应的插入物（6）分配相应的剂量。

公开(公告)号：EP1992378A1

公开(公告)日：2008-11-19

申请号：EP07009802.5

申请日：2007-05-16

申请人： Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： Rohrschneider, Marc ,  Besseler, Jens ,  von Brunn, Timo ,  Reinhold, Thomas Sowden

IPC分类号： A61M15/00

CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M15/0008 ,  A61M15/0031 ,  A61M15/0036 ,  A61M15/0041 ,  A61M15/0048 ,  A61M15/0061 ,  A61M15/0075 ,  A61M2016/0039 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/8225 ,  A61M2205/8293

摘要： A dispensing device having a storage device and an air pump for dispensing a medical formulation is proposed. The storage device comprises multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity (37). The cavities can be individually opened for dispensing the respective dose from the respective insert. The storage device comprises an empty or hollow or dummy receptacle (43) into which a connecting element can engage in a state before first use of when mounting the device.

摘要翻译： 提出了具有用于分配医疗制剂的储存装置和空气泵的分配装置。 储存装置包括多个插入物，每个插入物包含单剂量的制剂。 每个插入件位于一个单独的密封腔（37）中。 腔可以单独打开以从相应的插入物分配相应的剂量。 存储装置包括空的或中空的或虚拟的插座（43），连接元件在第一次使用之前可以接合在该插入状态中，以便在安装该装置时使用。

公开(公告)号：EP1992375A1

公开(公告)日：2008-11-19

申请号：EP07009799.3

申请日：2007-05-16

申请人： Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： von Brunn, Timo ,  Besseler, Jens ,  Dunne, Stephen T.

IPC分类号： A61M15/00

CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M15/0031 ,  A61M15/0036 ,  A61M15/0048 ,  A61M15/0061 ,  A61M15/0075 ,  A61M15/0081 ,  A61M2202/064 ,  A61M2205/071 ,  A61M2205/273 ,  A61M2205/8225

摘要： A dispensing device (1) having a storage device (4) and an air pump (18) for dispensing a medical formulation is proposed. The storage device comprises multiple inserts (6), each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities (37) can be individually opened for dispensing the respective dose from the respective insert. The device comprises means (22) for limiting the movement of the inserts.

摘要翻译： 提出了一种具有用于分配药物制剂的储存装置（4）和空气泵（18）的分配装置（1）。 存储装置包括多个插入物（6），每个插入物包含单剂量的制剂。 每个插件都位于一个独立的密封腔内。 腔体（37）可以单独打开以从相应的插入物分配相应的剂量。 该装置包括用于限制插入物移动的装置（22）。

公开(公告)号：EP1928410A2

公开(公告)日：2008-06-11

申请号：EP06815563.9

申请日：2006-09-28

申请人： Nektar Therapeutics

发明人： CHARAN, Chatan, K. ,  DWIVEDI, Sarvajna

IPC分类号： A61K9/00 ,  A61K31/7036

CPC分类号： A61K31/7036 ,  A61J1/065 ,  A61J1/1412 ,  A61K9/0019 ,  A61K9/0078 ,  A61K9/08 ,  A61K9/19 ,  A61K31/573 ,  A61K31/7034 ,  A61M11/001 ,  A61M16/04 ,  A61M2202/064

摘要： An aqueous or powder composition includes anti-gram-negative antibiotic or salt thereof being present at an amount ranging from about 100 mg/ml to about 200 mg/ml. Another aqueous or powder composition includes anti-gram-positive antibiotic or salt thereof being present at a concentration ranging from about 0.6 to about 0.9 of the water solubility limit, at 25° C. and 1.0 atmosphere, of the anti-gram-positive antibiotic or salt thereof. Other embodiments include unit doses, kits, and methods.

公开(公告)号：EP1907036A2

公开(公告)日：2008-04-09

申请号：EP06788045.0

申请日：2006-07-21

申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI

发明人： LARSON, David, W. ,  XU, Zhi

IPC分类号： A61M11/00

CPC分类号： A61M11/005 ,  A61M11/001 ,  A61M16/1095 ,  G01N30/74 ,  G01N30/84 ,  G01N2030/847 ,  G01N21/47

摘要： A focused droplet nebulizer (104) of the invention produces substantially uniform droplets (210) of a predetermined size. Droplets (210) are pushed out through a small outlet orifice (306) by the contraction of a chamber. The droplets (210) can b'e carried on a substantially non-divergent path in a drift tube (108). A piezo-controlled membrane micro pump (202) acts in response to an electrical control signal to force a droplet out of the outlet orifice (306). The nebulizer can operate at frequencies permitting a stream of individual droplets (210) of the predetermined size to be sent along the substantially non-divergent path in the drift tube (108) in a preferred embodiment ELSD device.

公开(公告)号：EP1549440A4

公开(公告)日：2007-11-07

申请号：EP03752006

申请日：2003-09-05

申请人： PHILIP MORRIS USA INC

发明人： NGUYEN TUNG T ,  MCREA DOUGLAS D ,  COX KENNETH A ,  NICHOLS WALTER A ,  SMITH ULYSSES ,  GROLLIMUND GARY E ,  BROOKMAN DONALD L

IPC分类号： A61M15/00 ,  A61M11/04 ,  B05B1/24 ,  B05B17/04 ,  A61M11/00 ,  B05C1/00

CPC分类号： B05B17/04 ,  A61M11/001 ,  A61M11/041 ,  A61M11/042 ,  A61M15/008 ,  A61M15/025 ,  A61M2205/50 ,  A61M2205/8206 ,  B05B1/24

摘要： An aerosol generating device generates an aerosol having a desired particle size by passing a liquid through a flow passage heated to convert the liquid into a vapor. The flow passage includes an outlet section that controls the exit velocity of the vapor and produces an aerosol with a desired particle size. The aerosol generator can be incorporated in a hand held inhaler, and the liquid can include a medicament, which is delivered to a targeted portion of the lung using the inhaler.

公开(公告)号：EP1819388A2

公开(公告)日：2007-08-22

申请号：EP05797355.4

申请日：2005-10-06

申请人： Boehringer Ingelheim International GmbH

发明人： DUNNE, Stephen, Terence ,  ROHRSCHNEIDER, Marc ,  MOSER, Achim

IPC分类号： A61M15/00 ,  A61M11/02

CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M11/002 ,  A61M11/02 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0051 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2205/8225 ,  A61M2206/16

摘要： A storage device (4) and a dispensing device (1) are proposed. The powder (2) is dispensed through a duct (5) with a flat cross section to de-agglomerate the powder and to generate a spray (3) with fine particle size. A storage chamber (10) for the powder may be closed by a bursting element (12), wherein pressurized gas can burst the bursting element for discharging the powder. Preferably, the cross section of a gas supply to the storage chamber controls the gas flow during dispensing of the powder. The storage device comprises multiple storage chambers and associated ducts or nozzles, so that each dose of powder can be dispensed through a separate duct or nozzle. The powder may be forced through the duct by a gas pressure of less than 300 kPa to de-agglomerate the powder and/or to generate the spray. Preferably, the gas pressure reaches or exceeds a peak value before the bursting element bursts and, then, the powder is dispensed by a lower gas pressure.

公开(公告)号：EP1795221A1

公开(公告)日：2007-06-13

申请号：EP06000866.1

申请日：2006-01-17

申请人： Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： Rohrschneider, Marc ,  Vehdelmann, Matthias ,  Dunne, Dr. Stephen T.

IPC分类号： A61M15/00

CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0031 ,  A61M15/0036 ,  A61M15/0048 ,  A61M15/0061 ,  A61M2202/064 ,  A61M2205/071 ,  A61M2205/8225

摘要： A dispensing device, a storage device and a method for dispensing a medical formulation are proposed. Multiple doses of the formulation are stored in a carrier having multiple inserts, each insert containing a single dose. Preferably, each insert comprises at least one duct or nozzle for dispensing the respective dose. Each insert is located in a separate and sealed cavity in the carrier. The cavities can be individually opened for dispensing the respective dose from the respective insert.

摘要翻译： 提出了一种分配装置，存储装置和用于分配医疗配方的方法。 将多剂量的制剂储存在具有多个插入物的载体中，每个插入物含有单一剂量。 优选地，每个插入件包括用于分配相应剂量的至少一个管道或喷嘴。 每个插入件位于载体中的单独且密封的腔中。 可以单独打开空腔以从相应的插入件分配相应的剂量。

公开(公告)号：EP1765291A1

公开(公告)日：2007-03-28

申请号：EP05748736.5

申请日：2005-06-01

申请人： Mederio AG

发明人： NIEMI, Alf ,  CALANDER, Sven ,  KAX, Lars

IPC分类号： A61K9/14 ,  A61K9/72 ,  A61M15/00

CPC分类号： A61M15/0028 ,  A61M11/001 ,  A61M2202/064

摘要： The invention relates to a method for enclosing a metered, dry powder medication dose comprising at least one active pharmaceutical ingredient (API) and a metered dose of at least one dry powder excipient in a common space of a dose container. The deposited doses in the common dose container constitute a medical product. The method and the medical product are effective in raising the emitted medication dose output and improving the therapeutic efficacy when the doses are delivered together from a dry powder inhaler.