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344 条记录 (耗时 0.021 秒)

    Antibodies against an IgE receptor
    54.
    发明公开
    Antibodies against an IgE receptor 失效
    Antikörpergegen einen IgE-Rezeptor。

    公开(公告)号：EP0499112A1

    公开(公告)日：1992-08-19

    申请号：EP92101732.3

    申请日：1992-02-03

    申请人： F. HOFFMANN-LA ROCHE AG

    发明人： Chizzonite, Richard Anthony ,  Hakimi, John ,  Kochan, Jarema Peter

    IPC分类号： C12P21/08 ,  C12N5/20 ,  C12N15/06 ,  G01N33/577 ,  G01N33/68 ,  A61K39/395

    CPC分类号： C07K16/283 ,  A61K38/00 ,  C07K2317/34

    摘要： The present invention is directed to a monoclonal antibody or a fragment thereof capable of binding to at least one epitope of the α-subunit of the human high affinity Fc IgE receptor, hybridoma cells secreting such a monoclonal antibody, a process for the preparation of such a hybridoma cell and for the preparation of such a monoclonal antibody or fragment thereof, pharmaceutical compositions containing such an antibody or fragment thereof and the use of such an antibody or fragment thereof for therapy, diagnosis and purification purposes.

    摘要翻译： 本发明涉及能够结合人高亲和力Fc IgE受体的α-亚单位的至少一个表位的单克隆抗体或其片段，分泌这种单克隆抗体的杂交瘤细胞，制备这种单克隆抗体的方法 杂交瘤细胞和这种单克隆抗体或其片段的制备，含有这种抗体或其片段的药物组合物以及这种抗体或其片段在治疗，诊断和纯化目的中的用途。

    Rat monoclonal antibodies directed against human antigens and processes for preparation thereof
    57.
    发明公开
    Rat monoclonal antibodies directed against human antigens and processes for preparation thereof 无效
    针对人类抗原的大鼠单克隆抗体及其制备方法

    公开(公告)号：EP0380018A3

    公开(公告)日：1990-08-29

    申请号：EP90101207.0

    申请日：1990-01-22

    申请人： ABBOTT LABORATORIES

    发明人： Bazin, Herve ,  De Bruyere, Marc

    IPC分类号： C12P21/08 ,  C12N5/20 ,  C12N15/06 ,  A61K39/395 ,  G01N33/577

    CPC分类号： C07K16/2812 ,  A61K38/00 ,  C07K2317/73

    摘要： A method of producing rat monoclonal antibodies to human T-cell lymphocyte antigen epitopes other than those epitopes defined by murine monoclonal antibodies directed to the same antigen comprising: (1) immunizing a rat or rat immunocompetent cells in vitro with an immunogenic amount of an antigen comprising T-cell lymphocyte markers; (2) fusing immunized cells from said rat or immunized rat immunocompetent cells with immunocytoma cells; (3) selecting hybridoma cells that produce antibody that binds to the human T-cell lymphocyte antigen epitopes other than those epitopes defined by murine monoclonal antibodies directed to the same antigen; (4) culturing the selected hybridoma cells; and (5) recovering said antibody. A method of producing rat monoclonal antibodies that bind to human CD4 antigen, the method comprising: (1) immunizing a rat or rat immunocompetent cells in vitro with an immunogenic amount of an antigen comprising CD4 molecule; (2) fusing immunized cells from said rat or immunized rat immunocompetent cells with immunocytoma cells; (3) selecting hybridoma cells that produce antibody that binds to human CD4 antigen; (4) culturing the selected hybridoma cells; and (5) recovering said antibody. A hybridoma that produces a rat monoclonal antibody that binds to human CD4 antigen. A rat monoclonal antibody that binds to human CD4 antigen. In a preferred embodiment the rat monoclonal antibody binds to a human CD4 antigen epitope other than those epitopes defined by murine monoclonal antibodies OKT4 and Leu3a. A rat monoclonal antibody that binds to human T-cell lymphocyte antigen epitopes other than those epitopes defined by murine monoclonal antibodies directed to the same antigen.

    Established cell line
    59.
    发明公开
    Established cell line 失效
    建立细胞线

    公开(公告)号：EP0220045A3

    公开(公告)日：1989-03-08

    申请号：EP86307921.6

    申请日：1986-10-14

    申请人： MITSUI TOATSU CHEMICALS, Inc.

    发明人： Kanai, Yoshiyuki ,  Awaya, Akira

    IPC分类号： C12N15/06 ,  C07K15/06 ,  A61K35/12 ,  A61K37/02 ,  C12P21/00

    CPC分类号： C07K16/18

    摘要： A novel established cell lint (ECACC 86 091801) is obtained by collecting lymphoid cells from an animal with autoimmune disease, culturing them in a culture medium containing the supernatant of a culture in which lymphoid cells of animal origin have been grown in the presence of a mitogen, and continuing the culture for a period of 8 months until the cells come to grow in the absence of the aforesaid supernatant. This established cell line has the following properties:
    (1) it produces a factor participating in the differentiation of antibody-producing cells. (2) it does not produce B cell growth factor. (3) it consists of immortalized null cells. This established cell line can be used to enhance the production of anti-nucleic acid antibodies by antibody-producing cells.