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    INDIVIDUALIZED CANCER TREATMENTS
    61.
    发明公开
    INDIVIDUALIZED CANCER TREATMENTS 审中-公开
    个性化癌症治疗

    公开(公告)号：EP2201135A2

    公开(公告)日：2010-06-30

    申请号：EP08833249.9

    申请日：2008-09-29

    申请人： Duke University

    发明人： POTTI, Anil ,  DRESSMAN, Holly, K. ,  NEVINS, Joseph, R.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： Provided herein are methods for the use of gene expression profiling to determine whether an individual afflicted with cancer will respond to a therapy, and in particular to therapeutic agents such as platinum-based agents and antimetabolite agents. Methods for the treatment of individuals with the therapeutic agents are also provided. Methods of predicting the efficacy of cancer therapeutic agents such as platinum-based and antimetabolite therapeutic agents are also provided. Kits including gene chips and instructions for predicting responsiveness are also provided.

    ISOLATION OF PROTEIN FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH NUCLEIC ACIDS
    62.
    发明公开
    ISOLATION OF PROTEIN FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH NUCLEIC ACIDS 有权
    明示或暗示的关联蛋白因子WITH NUCLEIC的隔震

    公开(公告)号：EP2191016A1

    公开(公告)日：2010-06-02

    申请号：EP08788385.6

    申请日：2008-08-20

    申请人： The General Hospital Corporation

    发明人： KINGSTON, Robert ,  DEJARDIN, Jerome

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6876 ,  C07K1/14 ,  C12Q1/6834 ,  C12Q2563/149 ,  C12Q2563/131 ,  C12Q2525/113

    摘要： Methods for isolating polypeptides and polypeptide complexes that are associated with a target nucleic acid sequence are provided. The methods comprise the steps of obtaining a sample that comprises a target nucleic acid sequence and one or more polypeptides or proteins associated with that target nucleic acid sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target nucleic acid sequence, wherein the oligonucleotide probe comprises at least one locked nucleic acid (LNA) nucleotide and wherein the oligonucleotide probe further comprises at least one affinity label (e.g. biotin); allowing the at least one oligonucleotide probe and the target nucleic acid sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label (e.g. using streptavidin-coated magnetic beads); and eluting the one or more polypeptides that are associated with the target nucleic acid sequence. Probes (e.g. with long spacer) for use in the methods of screening are also provided.