公开(公告)号：EP1613389A1

公开(公告)日：2006-01-11

申请号：EP04758751.4

申请日：2004-03-31

申请人： ALZA CORPORATION

发明人： DIONNE, Keith ,  MOSBAUER, Robert ,  DAVIS, Craig ,  PEERY, John

IPC分类号： A61M31/00 ,  A61K9/00

CPC分类号： A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

摘要： The present invention includes an osmotic pump that includes a means for venting an osmotic composition included in the pump before the internal pressure of the pump has the opportunity to build to such an extent that the pump is structurally compromised, such as when one or more components of the pump are physically separated. The means for venting osmotic material included in an osmotic pump according to the present invention includes a vent that allows the material included in the osmotic composition of the pump to dissipate into an environment of operation at a rate that results in dissipation of the pressure created within the osmotic pump and a reduced potential for subject discomfort or irritation.

公开(公告)号：EP1610761A2

公开(公告)日：2006-01-04

申请号：EP04758752.2

申请日：2004-03-31

申请人： ALZA CORPORATION

发明人： FEREIRA, Pamela, J. ,  LAUTENBACH, Scott ,  BERRY, Stephen

IPC分类号： A61K9/00

CPC分类号： A61K9/2013 ,  A61K9/0004 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K31/00 ,  A61K47/10

摘要： The present invention includes devices and methods for reducing the start-up time of osmotically driven drug delivery systems capable of delivering a desired drug at a controlled rate over time. In particular, the present invention includes osmotic pumps that have a preloaded membrane, which includes a semipermeable material that has been preloaded with a nonaqueous, incompressible liquid filler that is miscible with water. The present invention further includes methods for making such osmotic pumps. The preloaded membranes included in the osmotic pumps according to the present invention have proven to provide significant decreases in average start-up times relative to osmotic pumps that include semipermeable membranes that are not preloaded.

公开(公告)号：EP1600154A1

公开(公告)日：2005-11-30

申请号：EP05075190.8

申请日：1999-02-26

申请人： ALZA CORPORATION

发明人： Edgren, David E ,  Li, Shu ,  Bhatti, Gurdish, K ,  Wong, Patrick, S.L. ,  Skluzacek, Robert, R.

IPC分类号： A61K9/24 ,  A61K9/36

CPC分类号： A61K9/0004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/2886

摘要： A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.

摘要翻译： 一种剂型，其包含包含由内部和外壁包围的药物的组合物，其具有用于将药物施用于患者的出口; 并且对于指定的治疗公开了使用剂型的方法。

公开(公告)号：EP1596829A2

公开(公告)日：2005-11-23

申请号：EP04715163.4

申请日：2004-02-26

申请人： ALZA CORPORATION ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： ZALIPSKY, Samuel ,  BARENHOLZ, Yechezkel

IPC分类号： A61K9/127

CPC分类号： A61K9/1272 ,  A61K9/1271

摘要： A method for reducing complement activation upon in vivo administration of a liposome preparation containing an entrapped therapeutic agent is described. The method involves providing liposomes having a polyethylene-glycol-derived neutral lipopolymer.

公开(公告)号：EP1216036B1

公开(公告)日：2005-11-16

申请号：EP00964953.4

申请日：2000-09-08

申请人： ALZA CORPORATION

发明人： VAN OSDOL, William, W. ,  GALE, Robert, M. ,  BRANDWEIN, David, H. ,  PADMANABHAN, Rama ,  SUNRAM, Joan

IPC分类号： A61K9/70 ,  A61K31/155

CPC分类号： A61K9/7061 ,  A61K31/155

摘要： Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.

公开(公告)号：EP1562626A2

公开(公告)日：2005-08-17

申请号：EP03779390.8

申请日：2003-10-28

申请人： Alza Corporation

发明人： BENTZ, Johanna ,  KANG, Ling-Ling

IPC分类号： A61K38/16

CPC分类号： A61K9/0024 ,  A61K9/19 ,  A61K38/2278 ,  A61K47/02 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26

摘要： The present invention includes solid-state polypeptide particles containing a polypeptide material that is stabilized against degradation at temperatures that approximate or exceed physiological conditions. In each embodiment, the polypeptide particles of the present invention incorporate a polypeptide material that is stabilized against degradation by one or more stabilizing conditions. Because the polypeptide particles of the present invention can be formulated to combine the additive effects of two or\more stabilizing conditions, where the polypeptide particles of the present invention include a stabilizing sugar, the amount of stabilizing sugar needed to achieve acceptable polypeptide stability is significantly reduced.

公开(公告)号：EP1556017A1

公开(公告)日：2005-07-27

申请号：EP03781534.7

申请日：2003-10-31

申请人： ALZA Corporation

发明人： POLLOCK-DOVE, Crystal ,  DONG, Liang ,  WONG, Patrick, S., L. ,  YUM, Si-Hong

IPC分类号： A61K9/52

CPC分类号： A61K9/0004

摘要： The present invention includes a dosage form that releases a liquid active agent formulation over a period of time at an ascending rate. The dosage form of the present invention includes a capsule or other reservoir capable of containing a liquid active agent formulation, a driving means for expelling the liquid active agent formulation from the capsule over an extended period of time and a rate altering means for increasing the rate at which the driving means expels liquid active agent formulation from the capsule. The present invention also includes a method of manufacturing a controlled release dosage form providing the release of liquid active agent formulation at an ascending rate. The method of the present invention includes providing a capsule or reservoir suitable for containing a liquid active agent formulation, filling the capsule with a liquid active agent formulation, providing the capsule with a driving means for expelling the liquid active agent formulation from the capsule to an environment of use, and providing a rate altering means for increasing the rate at which the driving means expels the liquid active agent formulation.

公开(公告)号：EP1341442B1

公开(公告)日：2005-06-29

申请号：EP01977733.3

申请日：2001-10-12

申请人： Alza Corporation

发明人： TRAUTMAN, Joseph, C. ,  KEENAN, Richard, L. ,  CAO, Michael, T.

IPC分类号： A61B5/15

CPC分类号： A61M37/0015 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150282 ,  A61B5/150824 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/205 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44, 90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.

摘要翻译： 提供一种涂抹器装置（10）用于将具有一系列微凸起（90）的贴片（44）施加到角质层。 涂抹器装置（10）包括装置主体（12）和可在装置主体（12）内移动的活塞。 在装置主体（12）上提供帽（16），用于激活装置（10）以用微凸起阵列（44,90）冲击角质层。 装置（10）能够通过使用者的单手操作而被扳起，这允许装置（10）既不具有强度又不具有手动灵活性的患者使用以使其他类型的施用装置关闭。

公开(公告)号：EP1528942A1

公开(公告)日：2005-05-11

申请号：EP03761314.8

申请日：2003-06-24

申请人： Alza Corporation

发明人： GILBERT, Scott ,  DE LA SERNA, Pedro

IPC分类号： A61M5/20

CPC分类号： A61M5/2033 ,  A61M2005/206 ,  A61M2005/2418 ,  A61M2205/0266

摘要： The present invention provides a reusable spring device autoinjector. The drive mechanism of the autoinjector of the present invention includes one or more drive springs formed of a shape memory alloy. Therefore, by alternating the shape memory alloy forming the one or more drive springs between austenite phase before an injection and a martensite phase after injection, the reusable autoinjector of the present invention is capable of providing an injection force that is higher than the compressive force required to cock the drive mechanism in preparation for a subsequent injection operation.

公开(公告)号：EP1274399B1

公开(公告)日：2005-04-13

申请号：EP01906803.0

申请日：2001-01-26

申请人： Alza Corporation ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： ABRA, Robert, M. ,  BARENHOLZ, Yechezkel ,  LASIC, Danilo, D. ,  PELEG-SCHULMAN, Tal

IPC分类号： A61K9/127 ,  A61K33/24

CPC分类号： A61K33/24 ,  A61K9/1271 ,  A61K9/1277

摘要： A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.