ACELLULAR AMNION DERIVED THERAPEUTIC COMPOSITIONS

    公开(公告)号:EP3154557A4

    公开(公告)日:2018-04-25

    申请号:EP15810063

    申请日:2015-06-15

    Applicant: AMNIO TECH LLC

    Abstract: Acellular amnion derived therapeutic compositions are described having a number of various compositional embodiments. An acellular amnion derived therapeutic composition has essentially no live or active amniotic stems cells. The amniotic stem cells may be destroyed, and the cells and cell debris may be removed from the acellular amnion derived therapeutic composition. An acellular amnion derived therapeutic composition may comprise micronized amniotic membrane particles, and/or amniotic fluid. An acellular amnion derived therapeutic composition may be a dispersion of micronized amniotic membrane combined with a fluid, such as plasma, saline, amniotic fluid, combinations thereof and the like. An acellular amnion derived therapeutic composition may be combined with a matrix component to form a composite. An acellular amnion derived therapeutic composition may be used in conjunction with a composition comprising viable cells, such as stem cells.

    MICROPROJECTION ARRAY APPLICATOR AND METHOD
    5.
    发明公开
    MICROPROJECTION ARRAY APPLICATOR AND METHOD 审中-公开
    微型阵列阵列施加器和方法

    公开(公告)号:EP3253440A1

    公开(公告)日:2017-12-13

    申请号:EP16746000.5

    申请日:2016-02-02

    Abstract: The present invention relates to applicators for administering microprojection arrays to skin and methods of administering microprojection arrays. One embodiment of the present invention is a device for applying a microprojection array to a skin surface comprising: a) a housing having an upper and lower portion and having an internal face and an external face wherein the external face a flexible section that when collapsed actuates the device; b) a patch guide having a proximal and distal end wherein the proximal end interfaces with the internal face of the housing such that when the flexible section of the external face of the housing is collapsed the patch guide is forced downward; c) a cantilevered ring having an opening through which the patch guide passes and wherein the cantilevered ring is activated by the patch guide; d) a microprojection array that is contacted by the cantilevered ring when the ring is activated; e) a skin contact membrane; and f) a skin contact applicator base that attaches to the housing. A further embodiment of the present invention also includes two or more cantilevered rings having a first and a last ring, wherein the cantilevered rings are stacked such that when the device is actuated the first ring is fired such that each successive ring is contacted by the preceding ring.

    DEVICE FOR DELIVERY OF RHEUMATOID ARTHRITIS MEDICATION
    7.
    发明授权
    DEVICE FOR DELIVERY OF RHEUMATOID ARTHRITIS MEDICATION 有权
    用于输送类风湿关节炎药物的装置

    公开(公告)号:EP2563450B1

    公开(公告)日:2017-07-26

    申请号:EP11774518.2

    申请日:2011-04-27

    Abstract: Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.

    Abstract translation: 公开了用于穿过真皮屏障递送类风湿性关节炎药物的装置。 该装置包括用于穿透角质层的微针,还包括在微针表面上制造的结构以形成纳米形貌。 可以制造随机或非随机的结构图案,诸如包括不同尺寸和/或形状的结构的复杂图案。 微针表面上的结构图案可以包括纳米尺寸的结构。

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