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410 条记录 (耗时 0.018 秒)

    NITROSYLATED NEUROPEPTIDES
    61.
    发明授权
    NITROSYLATED NEUROPEPTIDES 失效
    亚硝基化神经肽

    公开(公告)号：EP0822826B1

    公开(公告)日：2001-09-12

    申请号：EP96911649.0

    申请日：1996-04-10

    申请人： BRIGHAM AND WOMEN'S HOSPITAL ,  TRUSTEES OF BOSTON UNIVERSITY

    发明人： STAMLER, Jonathan ,  SAENZ DE TEJADA, Inigo

    IPC分类号： A61K38/00 ,  C07K7/00 ,  C07K17/00

    CPC分类号： C07K14/57563 ,  A61K38/00

    摘要： Neuropeptides, particularly vasoactive intestinal peptide (VIP) and fragments, mutations and derivatives thereof that have corresponding activities to which have been directly or indirectly linked at least one NO or NO2 group, and their uses, including the relaxation of smooth muscle in several tissues, including vascular smooth muscle (e.g., aorta) and nonvascular smooth muscle (e.g. trachea, sphincter of Oddi, gastrointestinal smooth muscle and corpus cavernosum smooth muscle), and particularly also for the diagnosis and treatment of human male impotence.

    STIMULATION OF TANNING BY DNA FRAGMENTS
    67.
    发明授权
    STIMULATION OF TANNING BY DNA FRAGMENTS 失效
    与DNA片段晒黑促进

    公开(公告)号：EP0706369B1

    公开(公告)日：1997-12-17

    申请号：EP94923371.2

    申请日：1994-07-07

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： GILCHREST, Barbara, A. ,  YAAR, Mina ,  ELLER, Mark, S.

    IPC分类号： A61K7/48 ,  A61K7/42 ,  A61K31/70 ,  C12N5/00

    CPC分类号： A61Q19/04 ,  A61K8/606 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7048 ,  A61K45/06

    摘要： A method of stimulating pigment production in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of stimulating pigment production in mammalian cells, a method of stimulating melanogenesis in mammalian melanocytes, and a culture medium for stimulating melanin production. Preparations useful in the present methods are additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, dinucleotides, or dinucleotide dimers, in an appropriate vehicle, such as a liposomal preparation or propylene glycol. The preparations include DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers and an appropriate delivery vehicle, such as liposomes or a propylene glycol. The DNA fragments, deoxynucleotides, or dinucleotides used in the methods or in the preparations can be ultraviolet-irradiated. The preparations are sunlight-independent tanning or melanogenesis-stimulating agent.

    PREDICTIVE SELF-ORGANIZING NEURAL NETWORK
    68.
    发明授权
    PREDICTIVE SELF-ORGANIZING NEURAL NETWORK 失效
    预测自组织神经网络

    公开(公告)号：EP0569549B1

    公开(公告)日：1996-12-18

    申请号：EP92907182.7

    申请日：1992-01-30

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： CARPENTER, Gail, A. ,  GROSSBERG, Stephen ,  REYNOLDS, John, H.

    IPC分类号： G06K9/66

    CPC分类号： G06K9/6222 ,  G06N3/0409

    摘要： An A pattern recognition subsystem responds to an A feature representation input to select an A-category-representation and predict a B-category-representation and its associated B feature representation input. During learning trials, a predicted B-category-representation is compared to that obtained through a B pattern recognition subsystem. With mismatch, a vigilance parameter of the A-pattern-recognition subsystem is increased to cause reset of the first-category-representation selection. Inputs to the pattern recognition subsystems may be preprocessed to complement code the inputs.

    STIMULATION OF TANNING BY DNA FRAGMENTS
    70.
    发明公开
    STIMULATION OF TANNING BY DNA FRAGMENTS 失效
    与DNA片段晒黑促进

    公开(公告)号：EP0706369A1

    公开(公告)日：1996-04-17

    申请号：EP94923371.0

    申请日：1994-07-07

    申请人： TRUSTEES OF BOSTON UNIVERSITY

    发明人： GILCHREST, Barbara, A. ,  YAAR, Mina ,  ELLER, Mark, S.

    IPC分类号： A61K8 ,  A61K45 ,  A61Q19

    CPC分类号： A61Q19/04 ,  A61K8/606 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7048 ,  A61K45/06

    摘要： A method of stimulating pigment production in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of stimulating pigment production in mammalian cells, a method of stimulating melanogenesis in mammalian melanocytes, and a culture medium for stimulating melanin production. Preparations useful in the present methods are additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, dinucleotides, or dinucleotide dimers, in an appropriate vehicle, such as a liposomal preparation or propylene glycol. The preparations include DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers and an appropriate delivery vehicle, such as liposomes or a propylene glycol. The DNA fragments, deoxynucleotides, or dinucleotides used in the methods or in the preparations can be ultraviolet-irradiated. The preparations are sunlight-independent tanning or melanogenesis-stimulating agent.