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公开(公告)号：EP0939829B1
公开(公告)日：2008-08-20
申请号：EP97919904.9
申请日：1997-03-27
IPC分类号： C12N15/88 , D06L3/00 , G01N33/53 , G01N33/577
CPC分类号： C12N15/88 , A61K8/11 , A61K8/14 , A61K8/606 , A61K8/64 , A61K2800/782 , A61K2800/86 , A61Q5/08 , A61Q19/02 , D06L4/00
摘要： Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence encoding a peptide, that modulates the protein kinase C-beta-mediated activation of tyrosinase, the rate-limiting enzyme in melanogenesis.
摘要翻译： 描述了通过施用调节蛋白激酶C-β的物质，例如肽，抗体，抗体片段或编码肽的DNA序列的物质，可以使脊椎动物皮肤，毛发，羊毛或毛皮变亮或变暗的方法 介导的酪氨酸酶的活化，黑素生成中的限速酶。
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公开(公告)号：EP1761629A2
公开(公告)日：2007-03-14
申请号：EP05750059.7
申请日：2005-05-19
IPC分类号： C12N9/14
CPC分类号： G01N33/5041 , C12N15/1137 , C12N2310/13 , G01N33/5008 , G01N33/5011 , G01N33/6875 , G01N2510/00
摘要： The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or prolifertative senescence. Methods of identifying modulators of WRN are also described.
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公开(公告)号：EP0939829A1
公开(公告)日：1999-09-08
申请号：EP97919904.0
申请日：1997-03-27
CPC分类号： C12N15/88 , A61K8/11 , A61K8/14 , A61K8/606 , A61K8/64 , A61K2800/782 , A61K2800/86 , A61Q5/08 , A61Q19/02 , D06L4/00
摘要： Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence encoding a peptide, that modulates the protein kinase C-beta-mediated activation of tyrosinase, the rate-limiting enzyme in melanogenesis.
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4.发明授权COMPOSITION FOR INCREASING MELANIN CONTENT OF MELANOCYTES IN-VIVO AND IN-VITRO AND METHODS FOR THE IN-VITRO USE THEREOF 失效成分在体内或 黑色素含量的黑素细胞及其体外使用的体外生长。
公开(公告)号：EP0373195B1
公开(公告)日：1994-06-15
申请号：EP89904310.3
申请日：1989-03-27
IPC分类号： C12N5/00
CPC分类号： A61Q17/04 , A61K8/375 , A61K8/44 , A61K8/606 , A61K8/64 , A61K8/983 , A61K8/985 , A61K8/99 , A61Q5/00 , A61Q5/10 , A61Q19/02 , A61Q19/04 , C12N5/0626 , C12N2500/25 , C12N2501/01 , C12N2501/11 , C12N2501/39 , C12N2501/395
摘要： The present invention provides a variety of unique methods and compositions for inducing melanocyte proliferation and increases of melanin production in-vivo and in-vitro. Alternate compositions for use in these novel methods include a diacylglycerol and a conditioned medium derived from keratinocytes.
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公开(公告)号：EP0831850B1
公开(公告)日：2004-03-03
申请号：EP96919031.3
申请日：1996-06-03
发明人： GILCHREST, Barbara, A. , ELLER, Mark , YAAR, Mina
CPC分类号： A61K31/7048 , A61K31/711
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-induced dermatoses, and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed. The methods comprise administering to the cells of interest an effective amount of DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, or an agent that increases p53 activity. The DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers, or agent that increases p53 activity, can be administered in an appropriate vehicle, such as a liposomal preparation or propylene glycol. Preparations useful in the present methods are additionally disclosed. The preparations comprise DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, or an agent that increases p53 activity, and an appropriate delivery vehicle, such as liposomes or propylene glycol.
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公开(公告)号：EP0831850A1
公开(公告)日：1998-04-01
申请号：EP96919031.0
申请日：1996-06-03
发明人： GILCHREST, Barbara, A. , ELLER, Mark , YAAR, Mina
CPC分类号： A61K31/7048 , A61K31/711
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-induced dermatoses, and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed. The methods comprise administering to the cells of interest an effective amount of DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, or an agent that increases p53 activity. The DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers, or agent that increases p53 activity, can be administered in an appropriate vehicle, such as a liposomal preparation or propylene glycol. Preparations useful in the present methods are additionally disclosed. The preparations comprise DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, or an agent that increases p53 activity, and an appropriate delivery vehicle, such as liposomes or propylene glycol.
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7.发明授权Methods related to Alzheimer's disease for diagnosis, manufacture of medicaments and screening of substances and beta-amyloid related peptides 失效有用于诊断β-淀粉样蛋白肽衍生的阿耳茨海默氏病相关的方法，用于药物的制造和物质的筛选，以及
公开(公告)号：EP0890105B1
公开(公告)日：2006-11-22
申请号：EP97919932.0
申请日：1997-03-28
发明人： GILCHREST, Barbara, A. , YAAR, Mina
CPC分类号： C07K5/0815 , A61K38/00 , C07K14/4711 , C07K14/48 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Methods for evaluating the risk of an individual to develop Alzheimer's disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimer's disease using peptides that bind to the neurotrophin receptor (p75 ) and competitively inhibit the binding of beta -amyloid to the p75 .
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公开(公告)号：EP1053008B1
公开(公告)日：2004-11-03
申请号：EP99904572.7
申请日：1999-02-03
发明人： GILCHREST, Barbara, A. , YAAR, Mina , ELLER, Mark
CPC分类号： A61K8/64 , A61K31/713 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
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公开(公告)号：EP1053008A2
公开(公告)日：2000-11-22
申请号：EP99904572.7
申请日：1999-02-03
发明人： GILCHREST, Barbara, A. , YAAR, Mina , ELLER, Mark
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： A61K8/64 , A61K31/713 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual and a method of treating alopecia areata in an individual.
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公开(公告)号：EP0778779A2
公开(公告)日：1997-06-18
申请号：EP95930306.0
申请日：1995-08-30
发明人： GILCHREST, Barbara, A. , YAAR, Mina , ELLER, Mark
CPC分类号： A61K31/713 , A61K8/64 , A61K38/185 , A61Q7/00 , Y10S514/88
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.
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