公开(公告)号：EP1236706A4

公开(公告)日：2005-02-16

申请号：EP00970026

申请日：2000-10-24

Applicant: TOSOH F TECH INC

Inventor： NUKUI KAZUNORI ,  ABE HIROYUKI ,  NISHIDA TAKUJI ,  ARAI SHOJI

IPC: C01D3/04 ,  C05D1/02 ,  C07C27/00 ,  C07C29/09 ,  C07C29/124 ,  C07C31/38 ,  C07C67/10 ,  C07C29/58 ,  C07C69/62

CPC classification number: C07C29/095 ,  C05D1/02 ,  C07C67/10 ,  C07C69/63 ,  C07C31/38

Abstract: By making use of potassium chloride by-product that is produced in large amounts in a production process of 2,2,2-trifluoroethanol and its esters, potassium chloride suitable for use as a fertilizer is produced. Accordingly, the present invention makes it possible not only to effectively make use of the potassium chloride by-product, but also to reduce the cost in processing the waste products and prevent environmental pollution. The present invention provides a potassium chloride by-product for use as a fertilizer, the potassium chloride by-product produced in a process in which 1,1,1-trifluoro-2-chloroethane is reacted with a potassium salt of an organic carboxylic acid in the presence of polar aprotic solvent to form 2,2,2-trifluoroethanol and/or 2,2,2-trifluoroethyl ester of organic carboxylic acid, the potassium chloride by-product being characterized in that it contains organic materials in an amount of 3wt% or less.

公开(公告)号：EP1426351A1

公开(公告)日：2004-06-09

申请号：EP02760828.0

申请日：2002-09-13

Applicant: Tosoh F-Tech, Inc.

Inventor： NAGASAKI, Noritaka ,  KAWAMURA, Tsuyoshi ,  NUKUI, Kazunori ,  ARAI, Shoji

IPC: C07C29/124 ,  C07C29/80 ,  C07C31/38 ,  C07C51/09 ,  C07C59/01

CPC classification number: C07C29/124 ,  C07C31/38

Abstract: A method for producing 2,2,2-trifluoroethanol in which a γ-hydroxybutyric acid salt is reacted with 1,1,1-trifluoro-2-chloroethane to generate 2,2,2-trifluoroethanol is provided. This method leads to increased yields of 2,2,2-trifluoroethanol, facilitates the separation of salt byproducts and allows the recycling of an aprotic polar solvent.
The present invention concerns a method for producing 2,2,2-trifluoroethanol in which a γ-hydroxybutyric acid salt is reacted with 1,1,1-trifluoro-2-chloroethane in an aprotic polar solvent to generate 2,2,2-trifluoroethanol. This method is characterized in that the γ-hydroxybutyric acid salt used contains no more than 6wt% of 4,4'-oxybis(butyric acid).

Abstract translation: 提供一种制备2,2,2-三氟乙醇的方法，其中将γ-羟基丁酸盐与1,1,1-三氟-2-氯乙烷反应生成2,2,2-三氟乙醇。 该方法导致2,2,2-三氟乙醇的产率增加，促进了盐副产物的分离并允许非质子极性溶剂的再循环。 本发明涉及一种制备2,2,2-三氟乙醇的方法，其中γ-羟基丁酸盐在非质子极性溶剂中与1,1,1-三氟-2-氯乙烷反应生成2， 2,2-三氟乙醇。 该方法的特征在于所用的γ-羟基丁酸盐含有不超过6重量％的4,4'-氧双（丁酸）。

公开(公告)号：EP1403238A1

公开(公告)日：2004-03-31

申请号：EP02738894.1

申请日：2002-07-01

Applicant: Tosoh F-Tech, Inc.

Inventor： MIMURA, Hideyuki ,  KAWADA, Kosuke ,  ARAI, Shoji

IPC: C07C29/124 ,  C07C31/38

CPC classification number: C07C29/124 ,  C07C31/38

Abstract: A method for producing fluorinated alcohols from fluorinated alkyl halides can produce fluorinated alcohols at high product yield and at high selectivity in a single-step reaction. The method eliminates the need to use heavy metals and other toxic compounds that are difficult to handle or process.
Specifically, the method produces a fluorinated alcohol represented by the following general formula (2):

        Rf(A)OH     (2)

wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms; and A represents a straight-chained or branched saturated hydrocarbon group having 3 to 10 carbon atoms. The method is characterized in that it allows a fluorinated alkyl halide represented by the following general formula (1) to react with an alkali metal salt of 4-hydroxybutyrate in a gamma-butyrolactone solvent:

        Rf(A)X     (1)

wherein Rf and A are as defined above; and X represents a halogen atom.

Abstract translation: 一种制备氟化醇的新方法包括在γ-丁内酯溶剂中使氟代烷基卤化物与4-羟基丁基酸碱金属盐进行一步反应。 制备式R 1> -A-OH（I）的氟化醇的新方法包括使式R 1> -AX（II）的氟代烷基卤化物与γ-羟基丁基酸碱金属盐在γ- 丁内酯溶剂。 R1> 1-10C全氟烷基; A：3-10C饱和烃基; 和X：卤素原子。

公开(公告)号：EP1362842A1

公开(公告)日：2003-11-19

申请号：EP01272302.9

申请日：2001-12-25

Applicant: Tosoh F-Tech, Inc.

Inventor： KONDO, Norihisa ,  MIMURA, Hideyuki ,  NUKUI, Kazunori ,  KAWADA, Kosuke ,  ARAI, Shoji

IPC: C07C67/307 ,  C07C67/54 ,  C07C67/58 ,  C07C69/72 ,  C07C69/716 ,  C07C69/738

CPC classification number: C07C67/58 ,  C07C67/307 ,  C07C69/738 ,  C07C69/716

Abstract: A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3wt% or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated
3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.

Abstract translation: 提供了通过用氟气对3-氧代烷基羧酸酯进行氟化来制备2-氟-3-氧代烷基羧酸酯的方法。 该方法的特征在于，氟化反应混合物中3-氧代烷基羧酸酯的浓度保持在3wt％或更高。 本发明还提供了一种纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于通过洗涤氟化3-氧代烷基羧酸酯3次或更多次而以高收率和低杂质生产2-氟-3-氧代烷基羧酸酯 尽可能多的水作为反应混合物的量。 根据本发明的方法，不仅可以使不需要的副产物的产生最小化，而且可以以有效的方式纯化氟化3-氧代烷基羧酸酯。 因此，本发明允许有效地生产相当纯的2-氟-3-氧代烷基羧酸酯，这是一种用于生产各种医药和农药的有用中间体材料。