公开(公告)号：EP1403238A4

公开(公告)日：2006-01-25

申请号：EP02738894

申请日：2002-07-01

Applicant: TOSOH F TECH INC

Inventor： MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C29/124 ,  C07C31/38 ,  C07C31/42 ,  C07C31/44 ,  C07C205/43 ,  C07C233/10 ,  C07C233/28 ,  C07C233/33 ,  C07C233/44 ,  C07C233/55 ,  C07F9/12

CPC classification number: C07C29/124 ,  C07C31/38

Abstract: A process for producing a fluorinated alcohol from a fluoroalkyl halide through a one-stage reaction in high yield with high selectivity without using a highly toxic compound such as a heavy metal compound, which is difficult to handle or treat. The process, which is for producing a fluorinated alcohol represented by the general formula (2): Rf(A)OH (2) (wherein Rf represents C1-10 perfluoroalkyl and A represents a C3-10, linear or branched, saturated hydrocarbon group), is characterized by reacting a fluoroalkyl halide represented by the general formula (1): Rf(A)X (1) (wherein Rf and A are the same as defined above and X represents halogeno) with an alkali metal salt of 4-hydroxybutyric acid in Ϝ-butyrolactone as a solvent.

公开(公告)号：EP1236706A4

公开(公告)日：2005-02-16

申请号：EP00970026

申请日：2000-10-24

Applicant: TOSOH F TECH INC

Inventor： NUKUI KAZUNORI ,  ABE HIROYUKI ,  NISHIDA TAKUJI ,  ARAI SHOJI

IPC: C01D3/04 ,  C05D1/02 ,  C07C27/00 ,  C07C29/09 ,  C07C29/124 ,  C07C31/38 ,  C07C67/10 ,  C07C29/58 ,  C07C69/62

CPC classification number: C07C29/095 ,  C05D1/02 ,  C07C67/10 ,  C07C69/63 ,  C07C31/38

Abstract: By making use of potassium chloride by-product that is produced in large amounts in a production process of 2,2,2-trifluoroethanol and its esters, potassium chloride suitable for use as a fertilizer is produced. Accordingly, the present invention makes it possible not only to effectively make use of the potassium chloride by-product, but also to reduce the cost in processing the waste products and prevent environmental pollution. The present invention provides a potassium chloride by-product for use as a fertilizer, the potassium chloride by-product produced in a process in which 1,1,1-trifluoro-2-chloroethane is reacted with a potassium salt of an organic carboxylic acid in the presence of polar aprotic solvent to form 2,2,2-trifluoroethanol and/or 2,2,2-trifluoroethyl ester of organic carboxylic acid, the potassium chloride by-product being characterized in that it contains organic materials in an amount of 3wt% or less.

公开(公告)号：EP1426351A4

公开(公告)日：2006-03-01

申请号：EP02760828

申请日：2002-09-13

Applicant: TOSOH F TECH INC

Inventor： NAGASAKI NORITAKA ,  KAWAMURA TSUYOSHI ,  NUKUI KAZUNORI ,  ARAI SHOJI

IPC: C07C29/124 ,  C07C29/80 ,  C07C31/38 ,  C07C51/09 ,  C07C59/01

CPC classification number: C07C29/124 ,  C07C31/38

Abstract: The invention provides a process for the preparation of 2,2,2-trifluoroethanol by reacting a Ϝ-hydroxybutyric acid salt with 1,1,1-trifluoro-2-chloroethane which brings about an increase in the yield of 2,2,2-trifluoroethanol and enables easy separation of by-product salts and recovery and recycling of an aprotic polar solvent. The invention relates to a process for the preparation of 2,2,2-trifluoroethanol by reacting a Ϝ-hydroxybutyric acid salt with 1,1,1-trifluoro-2-chloroethane in an aprotic polar solvent, characterized by using a Ϝ-hydroxybutyric acid salt having a 4,4’-oxydibutyric acid content of 6 wt% or below.

公开(公告)号：EP1431269A4

公开(公告)日：2004-12-22

申请号：EP01972523

申请日：2001-09-27

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/54 ,  C07C69/716 ,  C07C67/307 ,  C07C67/58 ,  C07C69/72

CPC classification number: C07C67/54 ,  C07C69/716

Abstract: A method of separating a purified 2-fluoro-3-oxoalkylcarboxylic acid ester as a reaction product from a liquid reaction mixture obtained by fluorinating a 3-oxoalkylcarboxylic acid ester, characterized by comprising removing the hydrogen fluoride yielded as a by-product from the liquid reaction mixture and then separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. Thus, a high-purity 2-fluoro-3-oxoalkylcarboxylic acid ester, which is useful as an intermediate for medicines and agricultural chemicals, can be separated from the liquid reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester.

公开(公告)号：EP1637514A4

公开(公告)日：2006-09-20

申请号：EP04722998

申请日：2004-03-24

Applicant: TOSOH F TECH INC ,  SAGAMI CHEM RES

Inventor： FUCHIKAMI T ,  WAKASA NORIKO ,  TOKUHISA KENJI ,  MIMURA HIDEYUKI ,  ARAI SHOJI

IPC: C07C67/36 ,  B01J31/24 ,  C07C69/653

CPC classification number: C07C67/36 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2603/74 ,  C07C69/653

Abstract: A method for producing a fluorine-containing acrylate represented by CH2=C(Rf)(COOR), characterized in that 1-bromo-1-perfluoroalkylethene represented by CH2=CBr-Rf or 1,2-dibromo-1-perfluoroalkylethene represented by CH2Br-CHBr-Rf is reacted with an alcohol represented by ROH in the presence of a palladium catalyst, carbon monoxide and two or more types of bases. The fluorine-containing acrylate is a useful compound which has found widespread application as a raw material for a medicine, a functional polymer and the like.

Abstract translation: 一种由CH 2 = C（Rf）（COOR）表示的含氟丙烯酸酯的制备方法，其特征在于由CH 2 = CBr-Rf表示的1-溴-1-全氟烷基乙烯基或1,2-二溴-1 在钯催化剂，一氧化碳和两种或更多种碱的存在下，使由CH 2 CBr-CHBr-Rf表示的全氟烷基乙烷与由ROH表示的醇反应。 含氟丙烯酸酯是广泛用于药物和功能性聚合物的材料的有用化合物。

公开(公告)号：EP1623969A4

公开(公告)日：2006-09-20

申请号：EP04723004

申请日：2004-03-24

Applicant: TOSOH F TECH INC

Inventor： TOKUHISA KENJI ,  MIMURA HIDEYUKI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C57/54 ,  C07B61/00 ,  C07C51/10 ,  C07C51/12 ,  C07C57/52

CPC classification number: C07C57/54 ,  C07C57/52

Abstract: An ±-pentafluoroethyl acrylic acid derivative represented by the general formula [I]: [wherein R represents a hydrogen atom, a non-substituted or substituted aromatic ring, or a straight or branched alkyl group having 1 to 20 carbon(s) which may have a cyclic moiety optionally substituted with at least one substituent (halogen atom, hydroxyl group, straight or branched alkoxy group having 1 to 10 carbon(s) which may have a cyclic moiety, non-substituted or substituted aromatic group)].

Abstract translation: 由通式[I]表示的α-五氟乙基丙烯酸衍生物：其中R表示氢，（未）取代的芳族环或任选具有可具有一个或多个取代基的环状部分的C1-20直链或支链烷基 在卤代，羟基，任选具有环状部分的C1-10直链或支链烷氧基和（未）取代的芳香环之中）。

公开(公告)号：EP1362842A4

公开(公告)日：2005-06-29

申请号：EP01272302

申请日：2001-12-25

Applicant: TOSOH F TECH INC

Inventor： KONDO NORIHISA ,  MIMURA HIDEYUKI ,  NUKUI KAZUNORI ,  KAWADA KOSUKE ,  ARAI SHOJI

IPC: C07C67/307 ,  C07C67/54 ,  C07C67/58 ,  C07C69/716 ,  C07C69/72 ,  C07C69/738

CPC classification number: C07C67/58 ,  C07C67/307 ,  C07C69/738 ,  C07C69/716

Abstract: A process for preparing 2-fluoro-3-oxoalkylcarboxylic acid esters by fluorinating a 3-oxoalkylcarboxylic acid ester with fluorine gas, characterized in that the concentration of the 3-oxoalkylcarboxylic acid ester in the reaction fluid is kept at 3 wt% or above; and a process for purifying 2-fluoro-3- oxoalkylcarboxylic acid esters, characterized by washing a product of fluorination of a 3-oxoalkylcarboxylic acid ester with at least thrice as much water as the substrate to thereby obtain a purified 2-fluoro-3-oxoalkylcarboxylic acid ester in a high yield. According to these processes, high-purity 2-fluoro-3-oxoalkylcarboxylic acid esters useful as intermediates for drugs or agricultural chemicals can be efficiently prepared through inhibition of by-product formation or efficient purification of products of fluorination of 3-oxoalkylcarboxylic acid esters.

Abstract translation: 其特征在于，反应液中的3-氧代烷基羧酸酯的浓度保持在3重量％以上，其特征在于，所述反应液中的3-氧代烷基羧酸酯的浓度为3重量％以上。 和纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于用至少为底物3倍的水洗涤3-氧代烷基羧酸酯的氟化产物，从而得到纯化的2-氟-3- 氧代烷基羧酸酯。 根据这些方法，通过抑制副产物形成或有效纯化3-氧代烷基羧酸酯的氟化产物，可以有效地制备用作药物或农药中间体的高纯度2-氟-3-氧代烷基羧酸酯。