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    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE
    62.
    发明公开
    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开
    MARKER肾衰竭早期诊断

    公开(公告)号：EP3081939A1

    公开(公告)日：2016-10-19

    申请号：EP14868998.7

    申请日：2014-12-11

    申请人： Shiseido Company Ltd. ,  Kyushu University, National University Corporation

    发明人： HAMASE, Kenji ,  MIYOSHI, Yurika ,  MITA, Masashi

    IPC分类号： G01N33/68 ,  G01N33/493

    CPC分类号： G01N33/6812 ,  G01N2800/347

    摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN
    64.
    发明授权
    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN 有权
    皮肤美白剂和皮肤外用制剂

    公开(公告)号：EP2250999B1

    公开(公告)日：2016-04-13

    申请号：EP09707883.6

    申请日：2009-02-06

    申请人： Shiseido Company, Ltd.

    发明人： HANYU, Naoto ,  SAITO, Tomoko ,  SHIBATA, Takako ,  SATO, Kiyoshi ,  OGINO, Kimihiro

    IPC分类号： A61K8/49 ,  A61K31/4439 ,  A61K31/506 ,  A61P17/00 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein A is C 1-6 alkyl, C 5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C 1-6 alkyl, or C 2-6 alkenyl; " - - - " represents a single bond or a double bond whereinn = 1 or 2; Y is S or O; and R 3 and R 4 are each independently H, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R 3 is a group other than C 1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R 4 = Ra = H; X 1 = X 2 = CH; and either p = 0 or R 5 = C 1-6 alkyl.

    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND STORAGE MEDIUM
    66.
    发明公开
    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND STORAGE MEDIUM 有权
    VERFAHREN ZUR BEWERTUNG DER UV-LICHTSCHUTZWIRKUNG，BEWERTUNGSVORRICHTUNG UND SPEICHERMEDIUM

    公开(公告)号：EP2933628A1

    公开(公告)日：2015-10-21

    申请号：EP13862243.6

    申请日：2013-12-06

    申请人： Shiseido Company Ltd.

    发明人： HANYU, Naoto ,  NEGISHI, Eiichi ,  MIBAYASHI, Kazuhiko ,  SUMIYAMA, Takafumi

    IPC分类号： G01N21/33

    CPC分类号： G01N21/33 ,  G01N21/59

    摘要： A method for evaluating an ultraviolet radiation protection effect of a measurement sample applied on an application member includes a first step of selecting a first filter for measuring a spectral transmittance of the measurement sample before photodeterioration in a predetermined wavelength range by emission of light including ultraviolet radiation from a light source according to a preset light emission condition, and measuring the spectral transmittance, a second step of switching the first filter to a second filter for ultraviolet irradiation and causing the photodeterioration of the measurement sample through exposure to the ultraviolet radiation for a predetermined time after the measurement by the first step, and thereafter, switching the second filter to the first filter and measuring the spectral transmittance, and a third step of evaluating the ultraviolet radiation protection effect based on a change over time in the spectral transmittance obtained by repeating the second step over a predetermined time or a predetermined number of times.

    摘要翻译： 用于评估施加在施加构件上的测量样品的紫外线辐射防护效果的方法包括：第一步骤，通过发射包括紫外线的光，选择用于测量在预定波长范围内的光致变化之前的测量样品的光谱透射率的第一滤光器 根据预先设定的发光条件从光源开始，并测量光谱透射率;第二步骤，将第一过滤器切换到第二过滤器以进行紫外线照射，并通过暴露于紫外线照射预定的测量样品的光学变化， 之后，将第二滤波器切换到第一滤波器并测量分光透射率，以及第三步骤，基于通过重复获得的光谱透射率随时间的变化来评估紫外线辐射防护效果 第二 超过预定时间或预定次数。

    COSMETIC METHOD
    69.
    发明公开
    COSMETIC METHOD 审中-公开
    KOSMETISCHES VERFAHREN

    公开(公告)号：EP2907500A1

    公开(公告)日：2015-08-19

    申请号：EP13844768.5

    申请日：2013-10-11

    申请人： Shiseido Company Ltd.

    发明人： KIMURA, Tomoko ,  KANNO, Naomi ,  YAMAKI, Satoshi

    IPC分类号： A61K8/85 ,  A61K8/02 ,  A61K8/87 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00

    CPC分类号： A61K8/0216 ,  A61K8/735 ,  A61K8/85 ,  A61K2800/413 ,  A61K2800/884 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q1/14 ,  A61Q17/04 ,  A61Q19/00

    摘要： The present invention provides a cosmetic method having an excellent roughness correction effect and easily removing makeup cosmetic and sun care cosmetic.
    The cosmetic method of the present invention has a step of pasting the base material film surface of a thin film on the skin, a step of removing the support body of the pasted thin film, a step of applying a makeup cosmetic and/or a sun care cosmetic on the skin, wherein the thin film consists of a base material film of the thickness of 10 to 500 nm and a support body.

    摘要翻译： 本发明提供了一种具有优异的粗糙度校正效果并且容易地去除化妆品和防晒化妆品的化妆方法。 本发明的美容方法具有将薄膜的基材薄膜表面粘贴在皮肤上的步骤，去除粘贴薄膜的支撑体的步骤，涂敷化妆品和/或太阳的步骤 保护皮肤上的化妆品，其中薄膜由厚度为10至500nm的基材膜和支撑体组成。

    MAKEUP BASE COSMETIC FOR SKIN REMOVABLE WITH WARM WATER
    70.
    发明公开
    MAKEUP BASE COSMETIC FOR SKIN REMOVABLE WITH WARM WATER 有权
    MIT WARMWASSER ENTFERNBARE KOSMETISCHE BASISFÜRMAKE-UP

    公开(公告)号：EP2907499A1

    公开(公告)日：2015-08-19

    申请号：EP13845869.0

    申请日：2013-10-11

    申请人： Shiseido Company Ltd.

    发明人： KISHINA, Takahiro ,  KANEKO, Katsuyuki ,  TATSUTA, Amane ,  SATO, Yukiko ,  SHUDO, Minako ,  YAMAGUCHI, Masahiko ,  USUKI, Hiroyo ,  NOSAKA, Mikino ,  TAKESHITA, Nozomi

    IPC分类号： A61K8/81 ,  A61K8/34 ,  A61K8/60 ,  A61K8/86 ,  A61Q1/00 ,  A61Q1/14

    CPC分类号： A61K8/8135 ,  A61K8/062 ,  A61K8/345 ,  A61K8/60 ,  A61K8/86 ,  A61K2800/59 ,  A61Q1/02 ,  A61Q1/14

    摘要： [Problem] To provide a makeup base for skin that is applied to the skin before applying foundation and the like. The makeup base is not smeared or removed by sweat or cold water, but, when rubbed with warm water, it can be easily removed from the skin together with the makeup cosmetic without using a cleanser such as a makeup remover or a face wash.
    [Solution] A makeup base for skin applied to the skin before applying a makeup cosmetic for skin, the makeup base comprising a water-containing aqueous phase as a continuous phase and containing: (a) a vinyl acetate polymer, (b) polyhydric alcohol, and (c) a hydrophilic nonionic surfactant, wherein (a) the vinyl acetate polymer is 0.5 to 7 mass% in the makeup base and is dispersed as particles in the aqueous phase, (b) the polyhydric alcohol is 0.5 to 5.5 parts by mass relative to 1 part by mass of (a) the vinyl acetate polymer, and (c) the hydrophilic nonionic surfactant is 1 to 5 mass % in the makeup base.

    摘要翻译： [问题]提供在施用基础之前施加到皮肤上的皮肤的化妆基础等。 化妆底座不会被汗水或冷水污染或清除，但是当用温水擦拭时，可以与化妆妆品一起轻松地从皮肤上清除，而无需使用清洁剂，如卸妆液或洗面奶。 [解决方案]在施用化妆品皮肤之前，将皮肤施用于皮肤的化妆基底，所述补充基底包含含水水相作为连续相，并且包含：（a）乙酸乙烯酯聚合物，（b）多元醇 ，（c）亲水性非离子表面活性剂，其中，（a）所述补充基质中的乙酸乙烯酯聚合物为0.5〜7质量％，作为颗粒分散在水相中，（b）多元醇为0.5〜5.5份 （a）乙酸乙烯酯聚合物相对于1质量份的质量，和（c）亲水性非离子表面活性剂在化妆基料中为1〜5质量％。