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    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN
    1.
    发明公开
    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN 审中-公开
    HAUTBLEICHMITTEL UND EXTERNESPRÄPARATFÜRDIE HAUT

    公开(公告)号：EP2251001A1

    公开(公告)日：2010-11-17

    申请号：EP09709400.7

    申请日：2009-02-06

    申请人： Shiseido Company, Ltd.

    发明人： HANYU, Naoto ,  SAITO, Tomoko ,  SHIBATA, Takako ,  SATO, Kiyoshi ,  OGINO, Kimihiro

    IPC分类号： A61K8/49 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/506 ,  A61P17/00 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof:

    wherein A is C 1-6 alkyl, C 5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C 1-6 alkyl, or C 2-6 alkenyl; " - - - " represents a single bond or a double bond whereinn = 1 or 2; Y is S or O; and R 3 and R 4 are each independently H, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R 3 is a group other than C 1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R 4 = Ra = H; X 1 = X 2 = CH; and either p = 0 or R 5 = C 1-6 alkyl.

    摘要翻译： 本发明提供了对黑素生成具有优异抑制作用并可用作增白剂的化合物和含有该化合物的皮肤外用制剂。 本发明的增白剂作为活性成分，含有式（1）表示的杂环化合物或其药理学上可接受的盐：其中A为C 1-6烷基，C 5-6环烷基，苄基，苄基羰基，苯甲酰基 ，苯基，吡啶基或嘧啶基; R a是H，C 1-6烷基或C 2-6烯基; “ - - - ”表示单键或双键，其中n = 1或2; Y为S或O; R 3和R 4各自独立地为H，C 1-6烷基，羟基-C 1-6烷基，C 2-7酰基，苯基，吡啶基，嘧啶基等;条件是至少一个R 3为 在含有Y的杂环是噻唑啉环的情况下是C 1-3烷基以外的基团; R 4 = Ra = H; X 1 = X 2 = CH; p = 0或R 5 = C 1-6烷基。

    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN
    4.
    发明授权
    SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN 有权
    皮肤美白剂和皮肤外用制剂

    公开(公告)号：EP2250999B1

    公开(公告)日：2016-04-13

    申请号：EP09707883.6

    申请日：2009-02-06

    申请人： Shiseido Company, Ltd.

    发明人： HANYU, Naoto ,  SAITO, Tomoko ,  SHIBATA, Takako ,  SATO, Kiyoshi ,  OGINO, Kimihiro

    IPC分类号： A61K8/49 ,  A61K31/4439 ,  A61K31/506 ,  A61P17/00 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein A is C 1-6 alkyl, C 5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C 1-6 alkyl, or C 2-6 alkenyl; " - - - " represents a single bond or a double bond whereinn = 1 or 2; Y is S or O; and R 3 and R 4 are each independently H, C 1-6 alkyl, hydroxy-C 1-6 alkyl, C 2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R 3 is a group other than C 1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R 4 = Ra = H; X 1 = X 2 = CH; and either p = 0 or R 5 = C 1-6 alkyl.

    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND STORAGE MEDIUM
    5.
    发明公开
    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND STORAGE MEDIUM 有权
    VERFAHREN ZUR BEWERTUNG DER UV-LICHTSCHUTZWIRKUNG，BEWERTUNGSVORRICHTUNG UND SPEICHERMEDIUM

    公开(公告)号：EP2933628A1

    公开(公告)日：2015-10-21

    申请号：EP13862243.6

    申请日：2013-12-06

    申请人： Shiseido Company Ltd.

    发明人： HANYU, Naoto ,  NEGISHI, Eiichi ,  MIBAYASHI, Kazuhiko ,  SUMIYAMA, Takafumi

    IPC分类号： G01N21/33

    CPC分类号： G01N21/33 ,  G01N21/59

    摘要： A method for evaluating an ultraviolet radiation protection effect of a measurement sample applied on an application member includes a first step of selecting a first filter for measuring a spectral transmittance of the measurement sample before photodeterioration in a predetermined wavelength range by emission of light including ultraviolet radiation from a light source according to a preset light emission condition, and measuring the spectral transmittance, a second step of switching the first filter to a second filter for ultraviolet irradiation and causing the photodeterioration of the measurement sample through exposure to the ultraviolet radiation for a predetermined time after the measurement by the first step, and thereafter, switching the second filter to the first filter and measuring the spectral transmittance, and a third step of evaluating the ultraviolet radiation protection effect based on a change over time in the spectral transmittance obtained by repeating the second step over a predetermined time or a predetermined number of times.

    摘要翻译： 用于评估施加在施加构件上的测量样品的紫外线辐射防护效果的方法包括：第一步骤，通过发射包括紫外线的光，选择用于测量在预定波长范围内的光致变化之前的测量样品的光谱透射率的第一滤光器 根据预先设定的发光条件从光源开始，并测量光谱透射率;第二步骤，将第一过滤器切换到第二过滤器以进行紫外线照射，并通过暴露于紫外线照射预定的测量样品的光学变化， 之后，将第二滤波器切换到第一滤波器并测量分光透射率，以及第三步骤，基于通过重复获得的光谱透射率随时间的变化来评估紫外线辐射防护效果 第二 超过预定时间或预定次数。

    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM
    6.
    发明授权
    METHOD FOR EVALUATING ULTRAVIOLET LIGHT PROTECTION EFFECT, EVALUATION DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM 有权
    评估紫外线保护效果的方法，评估装置和计算机可读存储介质

    公开(公告)号：EP2933628B1

    公开(公告)日：2018-02-14

    申请号：EP13862243.6

    申请日：2013-12-06

    申请人： Shiseido Company Ltd.

    发明人： HANYU, Naoto ,  NEGISHI, Eiichi ,  MIBAYASHI, Kazuhiko ,  SUMIYAMA, Takafumi

    IPC分类号： G01N21/33 ,  G01N21/59

    CPC分类号： G01N21/33 ,  G01N21/59

    摘要： A method for evaluating an ultraviolet radiation protection effect of a measurement sample applied on an application member includes a first step of selecting a first filter for measuring a spectral transmittance of the measurement sample before photodeterioration in a predetermined wavelength range by emission of light including ultraviolet radiation from a light source according to a preset light emission condition, and measuring the spectral transmittance, a second step of switching the first filter to a second filter for ultraviolet irradiation and causing the photodeterioration of the measurement sample through exposure to the ultraviolet radiation for a predetermined time after the measurement by the first step, and thereafter, switching the second filter to the first filter and measuring the spectral transmittance, and a third step of evaluating the ultraviolet radiation protection effect based on a change over time in the spectral transmittance obtained by repeating the second step over a predetermined time or a predetermined number of times.