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    PROCESS FOR PRODUCING 3-ALKENYLCEPHEM COMPOUNDS
    63.
    发明公开
    PROCESS FOR PRODUCING 3-ALKENYLCEPHEM COMPOUNDS 失效
    用于生产3烯基头孢烯衍生物

    公开(公告)号：EP0990656A4

    公开(公告)日：2001-09-05

    申请号：EP98923112

    申请日：1998-06-04

    申请人： OTSUKA KAGAKU KK

    发明人： KAMEYAMA YUTAKA

    IPC分类号： C07D501/00 ,  C07D501/04 ,  C07D501/22 ,  C07D501/24

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： A process for producing 3-alkenylcephem compounds represented by general formula (3) characterized in that an iodination reagent, an alkali metal hydroxide or carbonate, an arylphosphine, and an aldehyde represented by the general formula (2): R4-CHO are caused to simultaneously act on a 3-chloromethylcephem compound represented by general formula (1) to thereby produce the target compound in one step, wherein R?1, R2, R3 and R4¿ are each as defined in the description.

    ANTIBACTERIAL AGENTS
    65.
    发明公开
    ANTIBACTERIAL AGENTS 审中-公开
    安非他明LE TEL ND ND IN IR IR IR IR IR IR IR IR IR IR IR IR IR IR

    公开(公告)号：EP1072267A1

    公开(公告)日：2001-01-31

    申请号：EP99913624.5

    申请日：1999-04-09

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： MATSUMOTO, Yoshimi ,  TAWARA, Shuichi ,  NISHIO, Hitoshi ,  HARIMOTO, Takashi ,  SEKIYAMA, Ryoji

    IPC分类号： A61K31/43 ,  A61K31/545 ,  C07D499/00 ,  C07D499/68 ,  C07D501/00 ,  C07D501/22

    CPC分类号： A61K31/546 ,  A61K31/43 ,  A61K31/545 ,  A61K2300/00

    摘要： The invention provides an antimicrobial agent capable of producing an excellent effect in the prevention or treatment of bacteria of two or more genera selected from among Streptococcus , Moraxella , Haemophilus , Klebsiella and the like. The agent comprises a penicillin antibiotic, in particular amoxicillin, and a cephem antibiotic, in particular cefixime or cefdinir. The antimicrobial agent of the invention is administered in the form of a mixed preparation containing both or in the form of individual preparations respectively containing them for combined administration.

    摘要翻译： 本发明提供能够在预防或治疗选自链球菌属，莫拉氏菌属，嗜血杆菌属，克雷伯氏菌属等中的两种以上的细菌中产生优异效果的抗微生物剂。 该试剂包括青霉素抗生素，特别是阿莫西林，和头孢类抗生素，特别是头孢克肟或头孢地尼。 本发明的抗微生物剂以混合制剂的形式施用，所述混合制剂同时含有或分别含有它们的单独制剂的形式，用于联合施用。

    PROCESS FOR THE PREPARATIONOF 2-SUBSTITUTED CEPHEM DERIVATIVES
    70.
    发明授权
    PROCESS FOR THE PREPARATIONOF 2-SUBSTITUTED CEPHEM DERIVATIVES 失效
    制备2-取代的头孢吡肟衍生物的方法

    公开(公告)号：EP0118567B1

    公开(公告)日：1994-03-30

    申请号：EP83902901.4

    申请日：1983-09-06

    申请人： OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA

    发明人： TORII, Shigeru ,  TANAKA, Hideo ,  NOGAMI, Junzo ,  SASAOKA, Michio ,  SAITO, Norio ,  SHIROI, Takashi

    IPC分类号： C07D501/22 ,  A61K31/545

    CPC分类号： C07D501/22 ,  Y02P20/55

    摘要： 2-Substituted cephem derivatives represented by the general formula (I), (wherein R1 represents substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, or substituted or unsubstituted phenoxymethyl, R2 represents hydrogen or a carboxylic acid-protecting group, Y represents allyloxy, benzyloxy, alkythio, carboxyalkylthio, or a group represented by the general formula of (II), R4 represents hydrogen or lower alkyl, X represents -O-, -S- or N-CH3, R5 represents hydrogen, lower alkyl or phenyl, and R6 represents hydrogen or lower alkyl), and a process for their preparation.

    摘要翻译： （I）表示的2-取代头孢烯衍生物，其中R1代表取代或未取代的苯基，取代或未取代的苯甲基或取代或未取代的苯氧基甲基，R2代表氢或羧酸保护基，Y代表烯丙氧基，苄氧基 ，烷硫基，羧基烷硫基或由通式（II）表示的基团，R 4表示氢或低级烷基，X表示-O - ， - S-或N-CH 3，R 5表示氢，低级烷基或苯基，并且R 6 代表氢或低级烷基），以及它们的制备方法。