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    PROCESS FOR THE PRODUCTION OF BETA-LACTAM COMPOUNDS
    2.
    发明公开
    PROCESS FOR THE PRODUCTION OF BETA-LACTAM COMPOUNDS 失效
    PROCESS FORβ-内酰胺化合物的制备

    公开(公告)号：EP0759428A4

    公开(公告)日：1998-11-11

    申请号：EP96905014

    申请日：1996-03-07

    申请人： OTSUKA KAGAKU KK

    发明人： TORII SIGERU ,  TANAKA HIDEO ,  SASAOKA MICHIO ,  KAMEYAMA YUTAKA

    IPC分类号： C07D205/09 ,  C07D499/00 ,  C07D499/06 ,  C07D205/08

    CPC分类号： C07D499/00 ,  C07D205/09

    摘要： A process for the production of a halogenated β-lactam compound represented by general formula (2) which comprises replacing the hydroxyl group of a halogenated β-lactam compound represented by general formula (1) with a halogen atom or a leaving group. Another process for the production of an exomethylene penam compound represented by general formula (5) which comprises reducing a halogenated β-lactam compound represented by general formula (2) with at least the equimolar amount of a metal having a standard oxidation-reduction potential of -0.3 (V/SCE) or below and 0.0001 to 10 times by mol as much a metal compound having a standard oxidation-reduction potential higher than that of the former metal, or employing the electrolytic reduction method.

    (1'R,3S,4R)4-acylthio azetidinones
    4.
    发明公开
    (1'R,3S,4R)4-acylthio azetidinones 失效
    （1'R，3S，4R）4-酰硫基氮杂环丁酮

    公开(公告)号：EP0574784A1

    公开(公告)日：1993-12-22

    申请号：EP93109103.7

    申请日：1993-06-07

    申请人： PHARMACIA S.p.A.

    发明人： Cabri, Walter ,  Candiani, Ilaria ,  Bedeschi, Angelo ,  Zarini, Franco

    IPC分类号： C07D205/09 ,  C07F7/18 ,  C07D401/12 ,  C07D405/12 ,  C07D499/88

    CPC分类号： C07D401/12 ,  C07D205/09 ,  C07D405/12 ,  C07D499/88 ,  C07F7/186 ,  Y02P20/55

    摘要： There is provided a process for preparing a compound of formula (I)

    wherein R is H or a hydroxy protecting group, R₂ is an organic residue and R₃ is H or a nitrogen protecting group, which process comprises reacting together a compound of formula (II)

    wherein R₁ is a C₁-C₄ alkyl or a phenyl group, R and R₃ are as defined above, a compound of formula (III)

    wherein R₂ is as defined above
    and X is a cation or a silicon-containing residue, and a salt of a group IIa, IIb or transition element. The compounds of formula (I) are intermediates in the synthesis of penem antibiotics.

    摘要翻译： 本发明提供了一种制备式（Ⅰ）化合物的方法，其中R是H或羟基保护基，R 2是有机残基，R 3是H或氮保护基，该方法包括使式（Ⅱ） ）其中R 1是C 1 -C 4烷基或苯基，R和R 3如上定义，式（Ⅲ）化合物（其中R 2如上定义，X​​是阳离子或含硅残基）和盐 的IIa，IIb族或过渡元素。 式（I）化合物是合成青霉烯类抗生素的中间体。

    Process for the preparation of 4-acyloxy-2-azetidinone derivatives
    5.
    发明公开
    Process for the preparation of 4-acyloxy-2-azetidinone derivatives 失效
    Verfahren zur Herstellung von 4-Acyloxy-2-azetidinone Derivate。

    公开(公告)号：EP0372699A1

    公开(公告)日：1990-06-13

    申请号：EP89310730.0

    申请日：1989-10-18

    申请人： SUNTORY LIMITED ,  NIPPON SODA CO., LTD.

    发明人： Ishiguro,Masaji ,  Iwata,Hiromitsu ,  Nakatsuka,Takashi ,  Yamada,Yasuo

    IPC分类号： C07D205/08 ,  C07D205/09

    CPC分类号： C07F7/186 ,  C07D205/08

    摘要： A process for producing 3-[1′-(R)-hydroxyethyl]-4-­acyloxyazetidinone from 3-[1′-(R)-hydroxyethyl]-4-alkyl (or aryl) thioazetidinone using a copper salt of aliphatic or aromatic carboxylic acid is disclosed. The process is an effective route for producing 3-[1′-(R)-hydroxyethyl]-4-acyloxyazetidinone, an intermediate for synthesizing penems or carbapenems, without using a mercury salt which can cause an environmental hazard.

    摘要翻译： 使用脂族或芳族的铜盐从3- [1分钟 - （R） - 羟乙基] -4-烷基（或芳基）硫代氮杂环丁酮生产3- [1分钟 - （R） - 羟乙基] -4-酰氧基氮杂环丁酮的方法 羧酸。 该方法是生产3- [1分钟 - （R） - 羟乙基] -4-酰氧基氮杂环丁酮的有效途径，它是一种用于合成青霉烯或碳青霉烯类的中间体，不使用会引起环境危害的汞盐。