公开(公告)号：EP2297120A1

公开(公告)日：2011-03-23

申请号：EP09739419.1

申请日：2009-04-15

申请人： Eli Lilly & Company

发明人： AUDIA, James, Edmund ,  MERGOTT, Dustin, James ,  SHEEHAN, Scott, Martin ,  WATSON, Brian, Morgan

IPC分类号： C07D279/06 ,  A61K31/541 ,  A61P25/28

CPC分类号： C07D279/06

摘要： The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.

公开(公告)号：EP2278968A2

公开(公告)日：2011-02-02

申请号：EP09735889.9

申请日：2009-04-02

申请人： ELI LILLY AND COMPANY

发明人： HU, Jingdan

IPC分类号： A61K31/4439 ,  C07D401/02

CPC分类号： C07D401/02

摘要： CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.

公开(公告)号：EP2238458A1

公开(公告)日：2010-10-13

申请号：EP08867898.2

申请日：2008-12-18

申请人： Eli Lilly & Company

发明人： LEOHR, Jennifer, K.

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N2800/044 ,  G01N2800/52

摘要： Methods for using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by a weight loss pharmaceutical agent. The biomarker may be used for determining if an individual patient will likely respond favorably to a given weight loss pharmaceutical agent.

公开(公告)号：EP2094709B1

公开(公告)日：2010-09-15

申请号：EP07842582.4

申请日：2007-09-17

申请人： ELI LILLY AND COMPANY

发明人： CHEN, Zhaogen ,  HAMDOUCHI, Chafiq, Hamdouchi ,  HEMBRE, Erik, James ,  HIPSKIND, Philip, Arthur ,  MYERS, Jason, Kenneth ,  TAKAKUWA, Takako ,  TOTH, James, Lee

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61P29/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.

摘要翻译： 本发明涉及式（I）化合物，其药物组合物及其作为促肾上腺皮质素释放因子1（CRF1）受体拮抗剂在治疗精神病和神经内分泌疾病，神经疾病和代谢综合征中的用途。

公开(公告)号：EP2162169A1

公开(公告)日：2010-03-17

申请号：EP08756103.1

申请日：2008-05-22

申请人： Eli Lilly & Company

发明人： MACK, Adam, Mekeel ,  RITSHER, Kenneth, Alan

IPC分类号： A61M5/20

CPC分类号： A61M5/20 ,  A61M5/008 ,  A61M5/326 ,  A61M2005/004 ,  A61M2005/14252 ,  A61M2005/1581 ,  A61M2005/206 ,  A61M2205/12 ,  A61M2205/6027 ,  A61M2205/6072 ,  A61M2205/6081

摘要： A cartridge (260) with injection needles for an injection device. The cartridge includes a plurality of injection needle assemblies (385), each including a hub and a needle. Each needle has ends that both face in a first direction. Each hub has one portion movable relative to another hub portion between a ready arrangement and a needle assembly lifting arrangement. The cartridge includes a needle assembly support that defines a plurality of mutually parallel, needle assembly accommodating cavities in which the needle assemblies are mounted to be shiftable in the first direction from a retracted position to an injection position.

公开(公告)号：EP2148880A1

公开(公告)日：2010-02-03

申请号：EP08747285.8

申请日：2008-05-01

申请人： ELI LILLY AND COMPANY

发明人： DALLY, Robert, Dean ,  HUANG, Jianping ,  JOSEPH, Sajan ,  SHEPHERD, Timothy, Alan ,  HOLST, Christian L.

IPC分类号： C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.

公开(公告)号：EP2099784A2

公开(公告)日：2009-09-16

申请号：EP07871196.7

申请日：2007-10-22

申请人： Eli Lilly & Company

发明人： SCHAUS, John Mehnert ,  HEATH, Perry Clark

IPC分类号： C07D401/12 ,  C07D207/38 ,  A61K31/4025 ,  A61P25/00

CPC分类号： C07D401/12 ,  C07D207/38

摘要： Compound and pharmaceutical compositions of Forumla by blockade of the CB1 receptors via an inverse agonism mechanism, and are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailabilty.

公开(公告)号：EP2040781A1

公开(公告)日：2009-04-01

申请号：EP07873504.0

申请日：2007-06-27

申请人： Eli Lilly & Company

发明人： ADLER, Ari, Tao ,  COLLINS, James, J., Jr. ,  COLUCCI, Jose, Jr. ,  JUDSON, Jared, Alden

IPC分类号： A61M5/315

CPC分类号： A61M5/31513 ,  A61J1/065 ,  A61M5/31515 ,  A61M2005/31516

摘要： A medication cartridge piston of a cartridge for an injection device. In one form, the piston includes a body (32) formed of a first material and including an interior hollow with a rearward facing mouth allowing for insertion of a drive member of the injection device. The body includes a first portion and a second portion disposed rearwared of the first portion, a sealing gland (34) secured to the body and formed of a material that is less rigid than the first material, the sealing gland ringing at least an axial segment of the second portion and having at least one exterior periphery region for sealingly engaging an interior surface of the cartridge barrel, and the body first portion including a thrust surface (4S) within the interior hollow for direct abutment by the drive member, at least a portion of the thrust surface disposed forward of a forward edge of a forwardmost sealing gland exterior periphery region of the at least one exterior periphery region. This piston can be operatively pulled by the drive member in a forward direction within the cartridge barrel to dispense medication from the cartridge. In an alternate embodiment, a piston is provided which is adapted for use with different drive members of injection devices.

公开(公告)号：EP4073051B1

公开(公告)日：2024-02-07

申请号：EP20829133.6

申请日：2020-12-07

发明人： COLE, Kevin Paul

IPC分类号： C07D305/06

公开(公告)号：EP4302826A2

公开(公告)日：2024-01-10

申请号：EP23206307.3

申请日：2020-06-19

申请人： Eli Lilly and Company

发明人： COATES, David Andrew ,  FIELDS, Todd ,  HO, Joseph Daniel ,  QU, Fucheng

IPC分类号： A61P3/10

摘要： In an embodiment, the present invention provides a compound of the formula:

or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.