公开(公告)号：EP1421943A1

公开(公告)日：2004-05-26

申请号：EP04003133.8

申请日：1998-05-25

申请人： Aventis Pharma S.A.

发明人： Stutzmann, Jean-Marie ,  Uzan, André ,  Wahl, Florence

IPC分类号： A61K31/715

CPC分类号： A61K31/715 ,  A61K31/727

摘要： Utilisation des héparines de bas poids moléculaire pour la prévention et le traitement du trauma du système nerveux central et notamment du traumatisme spinal, crânien ou crânio-spinal.

摘要翻译： 在治疗中用于预防和治疗中枢神经系统损伤的使用低分子量肝素，是新的。

公开(公告)号：EP1387837A1

公开(公告)日：2004-02-11

申请号：EP02730383.3

申请日：2002-05-02

申请人： Aventis Pharma S.A.

发明人： BABIN, Didier ,  WESTON, John

IPC分类号： C07D401/12 ,  C07D233/60 ,  A61K31/4725 ,  A61K31/4164 ,  A61P31/10

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar1, Ar3, A, R1, R5, R6, R7 and B are such as defined in the description, their preparation method and their use as antifungal medicines.

公开(公告)号：EP1235579B1

公开(公告)日：2003-07-16

申请号：EP00981453.4

申请日：2000-11-22

申请人： Aventis Pharma S.A.

发明人： BECOURT, Philippe ,  GEORGES, Robert ,  SEGOT CHICQ, Serge

IPC分类号： A61K31/575 ,  A61K9/20 ,  A61K47/00 ,  A61P15/12 ,  A61P15/18 ,  A61P19/10 ,  A61K31/565

CPC分类号： A61K31/565 ,  A61K2300/00

摘要： The invention concerns a pharmaceutical composition comprising trimegestone optionally associated with an oestrogen, characterised in that it comprises a buffer solution whereof the pH, when it is introduced in the composition, ranging essentially between 2 and 5.5. The invention also concerns the methods for making such a composition and the primary package containing them.

公开(公告)号：EP1140861B1

公开(公告)日：2003-07-02

申请号：EP00900538.0

申请日：2000-01-07

申请人： Aventis Pharma S.A.

发明人： BOUCHARD, Hervé ,  COMMERCON, Alain

IPC分类号： C07D241/12 ,  A61K31/495

CPC分类号： C07D241/12

公开(公告)号：EP1313737A1

公开(公告)日：2003-05-28

申请号：EP01956555.5

申请日：2001-07-23

申请人： Aventis Pharma Deutschland GmbH ,  Genentech Inc.

发明人： PEYMAN, Anushirwan ,  WILL, David ,  GADEK, Thomas, R. ,  McDOWELL, Robert ,  GOURVEST, Jean-François ,  RUXER, Jean-Marie ,  KNOLLE, Jochen

IPC分类号： C07D473/34 ,  C07D487/04 ,  A61K31/52 ,  A61P19/10

CPC分类号： C07D473/00 ,  C07D487/04

摘要： The present invention relates to acylguanidino derivatives of formula (I), in which R?1, R2, R3¿, A, B, X, Y and n have the meanings indicated in claim 1, their physiologically tolerable salts and their prodrugs. The compounds of the formula (I) are valuable pharmaceutically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and bone resorption by osteoclasts. This renders them suitable, for example, for the therapy and prophylaxis of illness which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth muscles. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as pharmaceutical active ingredients, and pharmaceutical compositions comprising them.

公开(公告)号：EP1133491B1

公开(公告)日：2003-02-19

申请号：EP99956121.0

申请日：1999-11-23

申请人： Aventis Pharma S.A. ,  Genentech, Inc.

发明人： CARNIATO, Denis ,  GADEK, Thomas, R. ,  GOURVEST, Jean-François ,  KNOLLE, Jochen ,  PEYMAN, Anurschirwan ,  BODARY, Sarah, C.

IPC分类号： C07D405/12 ,  A61K31/495

CPC分类号： C07D405/12

摘要： The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2 and CONHR6; R1, R2, R4, R5, R6 and R7 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and pharmaceutical compositions containing them.

公开(公告)号：EP1263721A1

公开(公告)日：2002-12-11

申请号：EP01909938.1

申请日：2001-03-01

申请人： Aventis Pharma S.A.

发明人： ACHARD, Daniel ,  BOUCHARD, Hervé ,  BOUQUEREL, Jean ,  FILOCHE, Bruno ,  GRISONI, Serge ,  HITTINGER, Augustin ,  MYERS, Michael

IPC分类号： C07D205/04 ,  C07D403/12 ,  C07D401/12 ,  C07D409/12 ,  A61K31/397 ,  A61P25/00

CPC分类号： C07D401/12 ,  C07D205/04 ,  C07D403/12 ,  C07D409/12

摘要： The invention concerns pharmaceutical compositions containing as active ingredient a compound of formula (I) wherein: R1 represents a -NHCOR4 or -N(R5)-Y-R6 radical; Y is CO or SO2; R4 represents an -alk-SO2R11, -alk-SO2-CH=CH-R11, Het substituted by -SO2R11 or phenyl substituted by -SO2-R11 or -alk-SO2-R11 radical; R5 represents a hydrogen atom or an alkyl radical; R6 represents a phenylalkyl radical, Het or Ar; the novel derivatives of formula (I) and their preparation.

公开(公告)号：EP1263720A1

公开(公告)日：2002-12-11

申请号：EP01909937.3

申请日：2001-03-01

申请人： Aventis Pharma S.A.

发明人： ACHARD, Daniel ,  BOUCHARD, Hervé ,  BOUQUEREL, Jean ,  FILOCHE, Bruno ,  GRISONI, Serge ,  HITTINGER, Augustin ,  MYERS, Michael

IPC分类号： C07D205/04 ,  C07D205/06 ,  C07D403/10 ,  C07D403/04 ,  C07D409/14 ,  C07D403/14 ,  C07D409/06 ,  C07D401/12 ,  C07D409/12 ,  C07D401/06 ,  C07D403/06 ,  A61K31/397 ,  A61P25/00

CPC分类号： C07D401/06 ,  C07D205/04 ,  C07D205/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14

摘要： The invention concerns a compound of formula (I) wherein R represents a CR1R2 radical, C=C(R5)SO2R6 or C=C(R7)SO2alk, their preparation and pharmaceutical compositions containing them.

公开(公告)号：EP1248652A2

公开(公告)日：2002-10-16

申请号：EP01903860.3

申请日：2001-01-03

申请人： Aventis Pharma S.A.

发明人： BASTIN, Richard ,  HART, Malcolm, Charles ,  HUGHES, Nicholas

IPC分类号： A61K47/02 ,  A61K47/12 ,  A61K31/4965

CPC分类号： A61K9/0095 ,  A61K31/4965

摘要： The invention concerns a stable aqueous deoxyfructosazine solution.

公开(公告)号：EP1235579A1

公开(公告)日：2002-09-04

申请号：EP00981453.4

申请日：2000-11-22

申请人： Aventis Pharma S.A.

发明人： BECOURT, Philippe ,  GEORGES, Robert ,  SEGOT CHICQ, Serge

IPC分类号： A61K31/575 ,  A61K9/20 ,  A61K47/00 ,  A61P15/12 ,  A61P15/18 ,  A61P19/10 ,  A61K31/565

CPC分类号： A61K31/565 ,  A61K2300/00

摘要： The invention concerns a pharmaceutical composition comprising trimegestone optionally associated with an oestrogen, characterised in that it comprises a buffer solution whereof the pH, when it is introduced in the composition, ranging essentially between 2 and 5.5. The invention also concerns the methods for making such a composition and the primary package containing them.