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公开(公告)号：EP0821728A1
公开(公告)日：1998-02-04
申请号：EP96910769.0
申请日：1996-04-05
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
IPC分类号： A61K , C07K , C12N , G01N33 , A61K38 , A61K39 , A61K45 , A61P3 , A61P7 , A61P9 , A61P35 , A61P43 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/515 , A61K38/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 另外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供了人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新血管生成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 表达TIE-2受体的细胞和减弱或预防人类肿瘤生长的方法。
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公开(公告)号：EP0784683A1
公开(公告)日：1997-07-23
申请号：EP95939501.0
申请日：1995-10-06
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
IPC分类号： C07K , C12N , G01N33 , A61K38 , A61K39 , A61K47 , A61K48 , A61K51 , A61P9 , A61P29 , A61P31 , A61P35 , C07H21 , C07K14 , C07K16 , C07K19 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
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73.发明公开
公开(公告)号：EP0644937A1
公开(公告)日：1995-03-29
申请号：EP93915340.0
申请日：1993-06-11
发明人： IP, Nancy , ALTAR, Charles, A. , DISTEFANO, Peter , VENTIMIGLIA, Roseann , WIEGAND, Stanley , WONG, Vivien , YANCOPOULOS, George, D.
CPC分类号： C07K14/475 , A61K38/00 , C07K14/48 , C07K14/71 , C07K2319/02
摘要： The present invention relates to neurotrophin-4 (NT-4), a newly characterized member of the BDNF/NGF/NT-3 gene family. The present invention provides for nucleic acid molecules encoding NT-4. Such molecules may comprise a sequence substantially as set forth for NT-4 in the figure [SEQ ID NO:1 (NT-4, viper)]. The present invention provides for therapeutic and diagnostic methods based on human NT-4 expression, specifically the potential to treat motor neuron diseases and prostate localized diseases, immunological related neuromuscular disorders, and peripheral and central nervous system disorders including Alzheimer's disease, Parkinson's disease and Huntington's chorea and epilepsy.
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