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公开(公告)号：EP0589961A1
公开(公告)日：1994-04-06
申请号：EP92912036.0
申请日：1992-04-23
发明人： SQUINTO, Stephen, P. , GLASS, David , ALDRICH, Thomas, H. , DiSTEPHANO, Peter , STITT, Trevor , FURTH, Mark, E. , YANCOPOULOS, George, D. , MAISONPIERRE, Peter, C. , MASIAKOWSKI, Piotr , IP, Nancy
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/71 , C07K14/82 , C12Q1/00 , C12Q1/02 , G01N33/50 , G01N33/573 , G01N33/6872 , G01N33/6896 , G01N2333/475
摘要： L'invention concerne des systèmes d'analyses qui peuvent être utilisés pour détecter et/ou mesurer l'activité de la neurotrophine et pour identifier des agents ayant une activité semblable à celle de la neurotrophine. L'invention se base, au moins en partie, sur la découverte que le proto-oncogène trkB code un récepteur de la tyrosine kinase qui peut servir de protéine de liaison fonctionnelle pour BDNF et NT-3. L'invention concerne également des procédés diagnostiques et thérapeutiques fondés sur l'interaction entre BDNF et/ou NT-3 et trkB, et pour plusieurs molécules réceptrices d'orphan.
摘要翻译： 本发明提供了可用于检测和/或测量神经营养因子活性并鉴定具有与神经营养因子相似活性的药剂的测定系统。 本发明至少部分基于发现trkB原癌基因编码可用作BDNF和NT-3的功能性结合蛋白的酪氨酸激酶受体。 本发明还涉及基于BDNF和/或NT-3和trkB之间以及几种孤儿受体分子之间相互作用的诊断和治疗方法。
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公开(公告)号：EP0821728B1
公开(公告)日：2004-08-11
申请号：EP96910769.7
申请日：1996-04-05
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
CPC分类号： C07K14/515 , A61K38/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
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公开(公告)号：EP0821728A1
公开(公告)日：1998-02-04
申请号：EP96910769.0
申请日：1996-04-05
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
IPC分类号： A61K , C07K , C12N , G01N33 , A61K38 , A61K39 , A61K45 , A61P3 , A61P7 , A61P9 , A61P35 , A61P43 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/515 , A61K38/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
摘要翻译： 本发明提供了编码人TIE-2配体的分离的核酸分子。 另外，本发明提供了特异性结合人TIE-2配体的受体体。 本发明还提供了特异性结合人TIE-2配体的抗体。 本发明进一步提供了人TIE-2的拮抗剂。 本发明还提供治疗组合物以及阻断血管生长的方法，促进新血管生成的方法，促进表达TIE-2受体的细胞的生长或分化的方法，阻断生长或分化的方法 表达TIE-2受体的细胞和减弱或预防人类肿瘤生长的方法。
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公开(公告)号：EP0784683A1
公开(公告)日：1997-07-23
申请号：EP95939501.0
申请日：1995-10-06
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
IPC分类号： C07K , C12N , G01N33 , A61K38 , A61K39 , A61K47 , A61K48 , A61K51 , A61P9 , A61P29 , A61P31 , A61P35 , C07H21 , C07K14 , C07K16 , C07K19 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
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公开(公告)号：EP0589961B1
公开(公告)日：2002-03-20
申请号：EP92912036.8
申请日：1992-04-23
发明人： SQUINTO, Stephen P. , GLASS, David , ALDRICH, Thomas, H. , DiSTEPHANO, Peter , STITT, Trevor , FURTH, Mark, E. , YANCOPOULOS, George, D. , MAISONPIERRE, Peter, C. , MASIAKOWSKI, Piotr , IP, Nancy
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/71 , C07K14/82 , C12Q1/00 , C12Q1/02 , G01N33/50 , G01N33/573 , G01N33/6872 , G01N33/6896 , G01N2333/475
摘要： The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity. It is based, at least in part, on the discovery that the trkB proto-oncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. The present invention also provides for diagnostic and therapeutic methods based on the interaction between BDNF and/or NT-3 and trkB, and for a number of orphan receptor molecules.
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公开(公告)号：EP0784683B1
公开(公告)日：2001-02-21
申请号：EP95939501.3
申请日：1995-10-06
发明人： DAVIS, Samuel , BRUNO, Joanne , GOLDFARB, Mitchell , ALDRICH, Thomas, H. , MAISONPIERRE, Peter, C. , RADZIEJEWSKI, Czeslaw , JONES, Pamela, F. , YANCOPOULOS, George, D.
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00
摘要： The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
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7.发明授权NEUROTROPHIN-3, A NOVEL NEUROTROPHIC FACTOR RELATED TO NERVE GROWTH FACTOR AND BRAIN DERIVED NEUROTROPHIC FACTOR 失效神经营养蛋白-3，A NEW神经营养因子神经生长因子和脑干ENDER亲神经因子相关
公开(公告)号：EP0441947B1
公开(公告)日：1997-05-14
申请号：EP90913954.5
申请日：1990-08-29
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , REGENERON PHARMACEUTICALS, INC.
发明人： HOHN, Andreas , LEIBROCK, Joachim , BAILEY, Karen , BARDE, Yves-Alain , THOENEN, Hans, F., E. , MAISONPIERRE, Peter, C. , FURTH, Mark, E. , LINDSAY, Ronald, M. , YANCOPOULOS, George
IPC分类号： C12P21/00 , C12N15/00 , C12Q1/00 , C07K14/475 , C07H15/12
CPC分类号： C07K14/475 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： The present invention relates to neurotrophin-3 (NT-3), a newly discovered member of the BDNF gene family. It is based, in part, on the identification of regions of nucleic acid sequence homology shared by BDNF and NGF (U.S. patent application Serial No. 400,591, filed August 30, 1989, incorporated by reference herein). According to the present invention, these regions of homology may be used to identify new members of the BDNF/NGF gene family; such methodology was used to identify NT-3. The present invention provides for the genes and gene products of new BDNF/NGF related neurotrophic factors identified by these methods. According to the invention, NT-3 may be used in the diagnosis and/or treatment of neurologic disorders, including, but not limited to, Alzheimer's disease and Parkinson's disease. Because NT-3 has been observed to exhibit a spectrum of activity different from the specificities of BDNF or NGF, NT-3 provides new and valuable options for enducing regrowth and repair in the central nervous system.
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8.发明公开NEUROTROPHIN-3, A NOVEL NEUROTROPHIC FACTOR RELATED TO NERVE GROWTH FACTOR AND BRAIN DERIVED NEUROTROPHIC FACTOR 失效神经营养蛋白-3，A NEW神经营养因子神经生长因子和脑干ENDER神经营养因子相关。
公开(公告)号：EP0441947A1
公开(公告)日：1991-08-21
申请号：EP90913954.0
申请日：1990-08-29
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , REGENERON PHARMACEUTICALS, INC.
发明人： HOHN, Andreas , LEIBROCK, Joachim , BAILEY, Karen , BARDE, Yves-Alain , THOENEN, Hans, F., E. , MAISONPIERRE, Peter, C. , FURTH, Mark, E. , LINDSAY, Ronald, M. , YANCOPOULOS, George
CPC分类号： C07K14/475 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： L'invention concerne la neurotrophine-3 (NT-3), un élément nouvellement découvert de la famille des gènes BDNF. L'invention se fonde en partie sur l'identification de régions d'homologie de fréquence d'acides nucléiques partagée par BDNF et NGF (demande de brevet d'invention US No. 400,591, déposée le 30 Août 1989, citée en référence dans la présente invention). Selon la présente invention, ces régions d'homologie peuvent être uilisées pour identifier de nouveaux éléments de la famille des gènes BDNF/NGF; une telle méthodologie a été utilisée pour identifier NT-3. La présente invention fournit les gènes et les produits génétiques des nouveaux facteurs neurotrophiques relatifs à BDNF/NGF identifiés par ces procédés. Selon l'invention, NT-3 peut être utilisé dans le diagnostic et/ou le traitement de troubles neurologiques, y compris mais de manière non exhaustive, la maladie d'Alzheimer et la maladie de Parkinson. Etant donné qu'on a observé que NT-3 présente un spectre d'activité différent des spécificités de BDNF ou NGF, NT-3 offre de nouvelles options intéressantes pour induire la reprise de la croissance et la réparation du système nerveux central.
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