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133 条记录 (耗时 0.06 秒)

    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI
    71.
    发明公开
    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI 审中-公开

    公开(公告)号：EP3912464A1

    公开(公告)日：2021-11-24

    申请号：EP21167679.6

    申请日：2013-03-07

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： MACDONALD, Lynn ,  MCWHIRTHER, John ,  TU, Naxin ,  STEVENS, Sean ,  MURPHY, Andrew J

    IPC分类号： A01K67/027 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46

    摘要： Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V H gene segment, a plurality of human D H gene segments and a plurality of human J H gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI
    72.
    发明公开
    HUMANIZED NON-HUMAN ANIMALS WITH RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN LOCI 审中-公开

    公开(公告)号：EP3597037A1

    公开(公告)日：2020-01-22

    申请号：EP19190845.8

    申请日：2013-03-07

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： MACDONALD, Lynn ,  MCWHIRTHER, John ,  TU, Naxin ,  STEVENS, Sean ,  MURPHY, Andrew J

    IPC分类号： A01K67/027 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46

    摘要： Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V H gene segment, a plurality of human D H gene segments and a plurality of human J H gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

    HUMANIZED UNIVERSAL LIGHT CHAIN MICE
    74.
    发明公开
    HUMANIZED UNIVERSAL LIGHT CHAIN MICE 审中-公开

    公开(公告)号：EP3572517A1

    公开(公告)日：2019-11-27

    申请号：EP19184217.8

    申请日：2012-08-03

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： MCWHIRTER, John ,  MACDONALD, Lynn ,  STEVENS, Sean ,  DAVIS, Samuel ,  BUCKLER, David R ,  HOSIAWA, Karolina A ,  MURPHY, Andrew J

    IPC分类号： C12N15/85 ,  A01K67/027 ,  C12N9/64 ,  C07K16/46

    摘要： Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V/J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided.

    MICE EXPRESSING A LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE
    80.
    发明公开
    MICE EXPRESSING A LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE 审中-公开
    EIN BEGRENZTES IMMUNGLOBULIN-LEICHTKETTENREPERTOIR EXPRIMIERENDEMÄUSE

    公开(公告)号：EP2967013A1

    公开(公告)日：2016-01-20

    申请号：EP14717331.4

    申请日：2014-03-13

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： BABB, Robert ,  MCWHIRTER, John ,  MACDONALD, Lynn ,  STEVENS, Sean ,  DAVIS, Samuel ,  BUCKLER, David R. ,  MEAGHER, Karolina A. ,  MURPHY, Andrew J.

    IPC分类号： A01K67/027 ,  C12N15/85 ,  C07K16/00 ,  C07K16/46

    CPC分类号： A01K67/0275 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/92 ,  C12N15/8509

    摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.

    摘要翻译： 提供遗传修饰的小鼠，其中小鼠表达特征在于有限数量的轻链可变结构域的免疫球蛋白轻链全序列。 提供提供两种人轻链可变基因片段的选择的小鼠，使得小鼠表达的免疫球蛋白轻链包含两个人轻链可变基因片段之一。 提供了使用本文所述的小鼠制备具有通用轻链的双特异性抗体的方法，包括人轻链可变区。 提供了适合用于多特异性结合蛋白（例如双特异性抗体）和宿主细胞的人可变区的方法。