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71.发明公开Methods, compositions and compound assays for inhibiting amyloid-beta protein production 审中-公开方法，组合物和测试化合物抑制β-淀粉样蛋白生产
公开(公告)号：EP2267458A3
公开(公告)日：2011-04-06
申请号：EP10174532.1
申请日：2005-04-20
申请人： Galapagos N.V.
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide (GPR12), or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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72.发明授权TRIAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES 有权三唑并吡啶化合物用于治疗退化性和炎性疾病
公开(公告)号：EP2086540B8
公开(公告)日：2011-03-02
申请号：EP07857236.9
申请日：2007-11-30
申请人： Galapagos N.V.
发明人： BURRITT, Andrew , EDWARDS, Paul John , SCHMIDT, Wolfgang , BIRAULT, Veronique , KROLL, Friedrich Erich Karl , TAO, Xueliang , ANDREWS, Martin James Inglis , MARTINA, Sébastien Laurent Xavier
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00
CPC分类号： C07D471/04
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73.发明公开Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases 审中-公开的退行性疾病和炎性疾病的治疗方法和化合物的识别
公开(公告)号：EP2256198A1
公开(公告)日：2010-12-01
申请号：EP10174544.6
申请日：2005-06-14
申请人： Galapagos N.V.
IPC分类号： C12N15/11
CPC分类号： C12Q1/37 , C12N9/6491 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/6887 , G01N2333/96486 , G01N2500/04 , G01N2800/102
摘要： The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.
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74.发明公开IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开炎症性疾病及适宜IMIDAZOLOPYRIDINVERBINDUNGEN退行性的治疗
公开(公告)号：EP2099798A1
公开(公告)日：2009-09-16
申请号：EP07847622.3
申请日：2007-11-30
申请人： Galapagos N.V.
发明人： EDWARDS, Paul John , MARTINA, Sébastien Laurent Xavier , ANDREWS, Martin James Inglis , BAR, Grégory Louis Joseph , ALLART, Brigitte , BURRITT, Andrew , TAO, Xueliang , KROLL, Friedrich Erich Karl
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel imidazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.
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75.发明公开METHODS, COMPOSITIONS AND COMPOUND ASSAYS FOR INHIBITING AMYLOID-BETA PROTEIN PRODUCTION 有权方法，组成和复合测定为了抑制淀粉样-β蛋白生产
公开(公告)号：EP1745295A2
公开(公告)日：2007-01-24
申请号：EP05744241.0
申请日：2005-04-20
申请人： Galapagos N.V.
IPC分类号： G01N33/68 , G01N33/566
CPC分类号： C12Q1/37 , G01N33/566 , G01N33/6896 , G01N2333/4709 , G01N2333/726 , G01N2500/00 , G01N2800/2821
摘要： A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, (eg. GPR3, GPR6, GPR12) or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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76.发明授权
公开(公告)号：EP3947378B1
公开(公告)日：2024-11-13
申请号：EP20715295.0
申请日：2020-03-24
发明人： MAMMOLITI, Oscar , JARY, Hélène, Marie , ORSULIC, Mislav , VRBAN, Denana , KOMAC, Marijana , BRYS, Reginald, Christophe, Xavier , AKKARI, Rhalid
IPC分类号： C07D471/04 , A61P31/18 , A61K31/662
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77.发明授权
公开(公告)号：EP3958863B1
公开(公告)日：2024-07-03
申请号：EP20721493.3
申请日：2020-04-21
IPC分类号： A61K31/4545 , A61K31/155 , A61K31/55 , A61P13/12 , A61K45/06
CPC分类号： A61P13/12 , A61K31/55 , A61K31/155 , A61K45/06 , A61K31/4545
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公开(公告)号：EP3378862B1
公开(公告)日：2022-03-16
申请号：EP17184834.4
申请日：2012-12-20
发明人： LABÉGUÈRE, Frédéric Gilbert , NEWSOME, Gregory John Robert , ALVEY, Luke Jonathan , SANIÈRE, Laurent Raymond Maurice , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/529 , A61P9/10
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公开(公告)号：EP3523293B1
公开(公告)日：2021-06-16
申请号：EP17794779.3
申请日：2017-10-06
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GRESZLER, Stephen N. , HOUSSEMAN, Christopher Gaëtan , KOENIG, John R. , KYM, Philip R. , LIU, Bo , SCANIO, Marc J. , SEARLE, Xenia , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D405/14 , A61P11/00 , A61K31/4439
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公开(公告)号：EP3365341B1
公开(公告)日：2020-05-13
申请号：EP16794525.2
申请日：2016-10-14
申请人： Galapagos N.V.
发明人： BRYS, Reginald, Christophe, Xavier , GENEY, Raphaël, Jean, Joël , JONCOUR, Agnès, Marie , DOYON, Julien, Georges, Pierre-Olivier , LABÉGUÈRE, Frédéric, Gilbert , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , SCHMITT, Benoît, Antoine , VAN DER PLAS, Steven, Emiel , MENET, Christel, Jeanne, Marie
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , A61P37/00
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