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公开(公告)号：EP2464754A4
公开(公告)日：2012-11-14
申请号：EP10808855
申请日：2010-08-13
发明人： MULERO JULIO , GREEN ROBERT , LAGACE ROBERT , HENNESSY LORI
CPC分类号： C07H21/04 , C12Q1/6879 , C12Q2600/156
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公开(公告)号：EP2464754A2
公开(公告)日：2012-06-20
申请号：EP10808855.0
申请日：2010-08-13
发明人： MULERO, Julio , GREEN, Robert , LAGACE, Robert , HENNESSY, Lori
CPC分类号： C07H21/04 , C12Q1/6879 , C12Q2600/156
摘要： Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.
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公开(公告)号：EP2258172A3
公开(公告)日：2012-06-13
申请号：EP10176917.2
申请日：2001-05-09
申请人： XY, LLC
CPC分类号： C12Q1/6879 , A61D19/00 , B03B9/00 , C12N5/061 , C12N5/0612 , G01F17/00 , G01N15/14 , G01N15/147 , G01N21/17 , G01N2015/149
摘要： Isolated non-naturally occurring populations of spermatozoa having high purity and technologies to differentiate spermatozoa based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics and detectors.
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公开(公告)号：EP2271772A2
公开(公告)日：2011-01-12
申请号：EP09720284.0
申请日：2009-03-10
申请人： SEQUENOM, INC.
CPC分类号： C12Q1/6879 , C12Q2600/16
摘要： Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid in a high copy number background of female nucleic acid, thereby determining the sex of a fetus and/or amount of fetal nucleic acid in a sample.
摘要翻译： 本文提供了用于从怀孕女性的细胞外核酸样品中无创，早期测定胎儿性别和/或胎儿核酸量的组合物，方法和试剂盒。 这种组合物，方法和试剂盒可用于检测雌性核酸的高拷贝数背景中的雄性胎儿核酸的低基因组拷贝数，由此确定样品中胎儿的性别和/或胎儿核酸的量。
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75.发明公开High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa 审中-公开高纯度的携带X染色体和携带y染色体的精子群体
公开(公告)号：EP2258174A2
公开(公告)日：2010-12-08
申请号：EP10176924.8
申请日：2001-05-09
申请人： XY, LLC
CPC分类号： C12Q1/6879 , A61D19/00 , B03B9/00 , C12N5/061 , C12N5/0612 , G01F17/00 , G01N15/14 , G01N15/147 , G01N21/17 , G01N2015/149
摘要： Isolated non-naturally occurring populations of spermatozoa having high purity and technologies to differentiate spermatozoa based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics and detectors.
摘要翻译： 分离的非天然存在的具有高纯度的精子和基于诸如质量，体积，取向或发射光的特征来区分精子的技术包括分析和设备（例如光束成形光学器件和检测器）的技术。
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公开(公告)号：EP2258173A2
公开(公告)日：2010-12-08
申请号：EP10176919.8
申请日：2001-05-09
申请人： XY, LLC
CPC分类号： C12Q1/6879 , A61D19/00 , B03B9/00 , C12N5/061 , C12N5/0612 , G01F17/00 , G01N15/14 , G01N15/147 , G01N21/17 , G01N2015/149
摘要： Isolated non-naturally occurring populations of spermatozoa having high purity and technologies to differentiate spermatozoa based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics and detectors.
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公开(公告)号：EP2258171A2
公开(公告)日：2010-12-08
申请号：EP10176910.7
申请日：2001-05-09
申请人： XY, LLC
CPC分类号： C12Q1/6879 , A61D19/00 , B03B9/00 , C12N5/061 , C12N5/0612 , G01F17/00 , G01N15/14 , G01N15/147 , G01N21/17 , G01N2015/149
摘要： Isolated non-naturally occurring populations of spermatozoa having high purity and technologies to differentiate spermatozoa based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics and detectors.
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78.发明公开SPERM CELL SEPARATION METHODS AND COMPOSITIONS CONTAINING APTAMERS OR NUCLEIC ACID SEQUENCES FOR USE THEREIN 审中-公开精细胞分离方法和组合物与其中使用的适体或核酸序列
公开(公告)号：EP2061478A4
公开(公告)日：2010-07-07
申请号：EP07841662
申请日：2007-08-30
申请人： BIOCERN INC
CPC分类号： C12Q1/6811 , C12N5/061 , C12N5/0612 , C12N15/115 , C12N2310/16 , C12N2320/10 , C12Q1/6879
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公开(公告)号：EP1886138A4
公开(公告)日：2009-04-15
申请号：EP06721493
申请日：2006-05-11
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/569 , G01N33/68
CPC分类号： C12Q1/6881 , C12Q1/6879 , C12Q1/6883 , C12Q2600/158 , G01N33/5002 , G01N33/5044 , G01N33/5091 , G01N33/5094 , G01N33/54326 , G01N33/56966 , G01N33/573
摘要： The present invention relates to methods of enriching fetal cells from a pregnant female. The present invention relates to removing, from a sample, cells that comprise at least one MHC molecule. The present invention also relates to methods that rely on using telomerase, mRNA encoding components thereof, as well as telomere length, as markers for fetal cells. Enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
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公开(公告)号：EP1886138A1
公开(公告)日：2008-02-13
申请号：EP06721493.2
申请日：2006-05-11
CPC分类号： C12Q1/6881 , C12Q1/6879 , C12Q1/6883 , C12Q2600/158 , G01N33/5002 , G01N33/5044 , G01N33/5091 , G01N33/5094 , G01N33/54326 , G01N33/56966 , G01N33/573
摘要： The present invention relates to methods of enriching fetal cells from a pregnant female. The present invention relates to removing, from a sample, cells that comprise at least one MHC molecule. The present invention also relates to methods that rely on using telomerase, mRNA encoding components thereof, as well as telomere length, as markers for fetal cells. Enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
摘要翻译： 本发明涉及从怀孕女性富集胎儿细胞的方法。 本发明涉及从样品中去除包含至少一个MHC分子的细胞。 本发明还涉及依赖于使用端粒酶，编码其组分的mRNA以及端粒长度作为胎儿细胞的标记物的方法。 富含胎儿细胞可以用于多种程序，包括检测诸如疾病特征或其遗传易感性之类的感兴趣性状，性别分型和亲子鉴定。
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