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96 条记录 (耗时 0.027 秒)

    Dose counter for inhalers and inhaler
    82.
    发明授权
    Dose counter for inhalers and inhaler 有权
    DosiszählwerkfürInhalatoren und Inhalator

    公开(公告)号：EP2436414B1

    公开(公告)日：2015-03-11

    申请号：EP11004101.9

    申请日：2011-05-18

    申请人： Ivax Pharmaceuticals Ireland ,  Norton Waterford ,  TEVA Parmaceuticals Ireland

    发明人： Uschold, Robert Charles ,  Karg, Jeffrey A. ,  Clancy, Paul ,  Fenlon, Derek ,  Walsh, Declan ,  Kaar, Simon ,  Hazenberg, Jan Geert ,  Buck, Dan

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0078 ,  A61M11/00 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/0065 ,  A61M15/007 ,  A61M15/0071 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/6063 ,  A61M2207/00 ,  A61M2207/10 ,  G06M1/246 ,  Y10T29/49 ,  Y10T29/49764 ,  Y10T29/49826

    摘要： A manually operated measured dose inhaler (12) includes a dose counter chamber (66) including a dose display tape (112) driven by a ratchet wheel (94) which is driven in turn by an actuator pawl (80), actuated by movement of a canister (20); two-step ribs (144, 146) being provided to prevent rocking of the canister (20); a drain hole (194) being provided for preventing misting of a display window (118); and frictional surfaces (132, 134) being provided on a shaft (108) of a tape stock bobbin (110) to prevent tape slippage; a rotation regulator being provided for the stock bobbin and comprising a wavelike engagement surface (300) with concavities (302) which engage against control elements (128, 130) in the form of protrusions on resilient forks of a split pin (108) thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

    摘要翻译： 手动操作的测量剂量吸入器（12）包括剂量计数器室（66），其包括由棘轮（94）驱动的剂量显示带（112），所述剂量显示带由致动器棘爪（80）依次驱动， 罐（20）; 提供两级肋（144,146）以防止罐（20）摇动; 设置用于防止显示窗（118）雾化的排水孔（194）; 并且摩擦表面（132,134）设置在带状线轴（110）的轴（108）上，以防止胶带滑动; 旋转调节器被设置用于股票线轴并且包括具有凹陷（302）的波纹接合表面（300），所述波形接合表面（300）与分裂销（108）的弹性叉上的突起形式的控制元件（128,130）接合，从而允许 如果吸入器落在硬表面上，则库存筒管的增量展开能抵抗过度旋转。

    Dose counters for inhalers, inhalers and shafts thereof
    84.
    发明授权
    Dose counters for inhalers, inhalers and shafts thereof 有权
    DouszählwerkefürInhalatoren，Inhalatoren und derenSchäfte

    公开(公告)号：EP2502644B1

    公开(公告)日：2014-12-31

    申请号：EP12003933.4

    申请日：2011-05-18

    申请人： Ivax Pharmaceuticals Ireland ,  Norton Waterford ,  TEVA Parmaceuticals Ireland

    发明人： Fenlon, Derek ,  Clancy, Paul ,  Uschold, Robert Charles ,  Walsh, Declan ,  Kaar, Simon ,  Hazenberg, Jan Geert ,  Buck, Dan Knockane ,  Karg, Jeffrey A.

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0078 ,  A61M11/00 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/0065 ,  A61M15/007 ,  A61M15/0071 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/6063 ,  A61M2207/00 ,  A61M2207/10 ,  G06M1/246 ,  Y10T29/49 ,  Y10T29/49764 ,  Y10T29/49826

    摘要： A manually operated measured dose inhaler (12) includes a dose counter chamber (66) including a dose display tape (112) driven by a ratchet wheel (94) which is driven in turn by an actuator pawl (80), actuated by movement of a canister (20); two-step ribs (144, 146) being provided to prevent rocking of the canister (20); a drain hole (194) being provided for preventing misting of a display window (118); and frictional surfaces (132, 134) being provided on a shaft (108) of a tape stock bobbin (110) to prevent tape slippage; a rotation regulator being provided for the stock bobbin and comprising a wavelike engagement surface (300) with concavities (302) which engage against control elements (128, 130) in the form of protrusions on resilient forks of a split pin (108) thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

    摘要翻译： 手动操作的测量剂量吸入器（12）包括剂量计数器室（66），其包括由棘轮（94）驱动的剂量显示带（112），所述剂量显示带由致动器棘爪（80）依次驱动， 罐（20）; 提供两级肋（144,146）以防止罐（20）摇动; 设置用于防止显示窗（118）雾化的排水孔（194）; 并且摩擦表面（132,134）设置在带状线轴（110）的轴（108）上，以防止胶带滑动; 旋转调节器被设置用于股票线轴并且包括具有凹陷（302）的波纹接合表面（300），所述波形接合表面（300）与分裂销（108）的弹性叉上的突起形式的控制元件（128,130）接合，从而允许 如果吸入器落在硬表面上，则库存筒管的增量展开能抵抗过度旋转。

    Heat sterilization of glucocorticoidsteriods
    85.
    发明公开
    Heat sterilization of glucocorticoidsteriods 有权
    糖皮质激素的热消毒

    公开(公告)号：EP2805712A1

    公开(公告)日：2014-11-26

    申请号：EP14001800.3

    申请日：2005-05-17

    申请人： Norton Healthcare Limited

    发明人： Ashley, Adrian. ,  Lamb, Paul. ,  Mcdonald, Donald. ,  Miller, John. ,  Oliver, Martin.J. ,  Pollard, Mathew.

    IPC分类号： A61K9/10

    CPC分类号： A61K9/1682 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61L2/0011 ,  A61L2/0023 ,  C07J5/00

    摘要： The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.

    摘要翻译： 本发明提供了一种不稳定的糖皮质激素的灭菌方法，该方法包括通过湿热对处于悬浮液形式的不稳定的糖皮质激素进行热消毒以达到消毒有效的时间。 根据本发明的方法和组合物可用作预防，逆转和/或减轻哺乳动物患者中过敏性和/或炎性病症症状的治疗工具。 本发明还提供了方法和组合物，其可以被操作并被微调以适应待治疗的病症，同时产生更少的副作用。

    Inhaler
    86.
    发明公开
    Inhaler 审中-公开
    气雾

    公开(公告)号：EP2799102A2

    公开(公告)日：2014-11-05

    申请号：EP14001801.1

    申请日：2010-06-08

    申请人： Ivax Pharmaceuticals Ireland

    发明人： Kaar, Simon G. ,  Walsh, Declan ,  Fenlon, Derek ,  Buck, Dan

    IPC分类号： A61M15/00

    CPC分类号： A61M15/009 ,  A61M15/0026 ,  A61M15/0091 ,  A61M15/0093 ,  A61M15/0096

    摘要： An inhaler (10), such as a breath-actuated metered-dose inhaler, for delivering medicament to a patient. The inhaler (10) comprises a housing for holding the medicament and having an air inlet means (12) and a medicament delivery port which together define an air flow path into which the medicament is dispensed. The air inlet means (12) comprises an array of elongate apertures (24) formed in the housing, the long sides of adjacent apertures (24) facing each other. Each aperture (24) is provided with a respective different opening In an outer surface of the housing. The opening of each aperture (24) extends in two different planes such that, if at least a part of the opening is covered in one of the two different planes during inhalation by the patient, a void space is created between the cover and the aperture (24) so as to provide an air flow path through the void space to the at least one aperture (24).

    摘要翻译： 吸入器（10），例如呼吸致动的计量吸入器，用于将药物输送给患者。 吸入器（10）包括用于保持药物并具有空气入口装置（12）和药物输送端口的壳体，所述空气入口装置和药物输送端口共同限定了分配药物的空气流动路径。 空气入口装置（12）包括形成在壳体中的细长孔（24）的阵列，相邻孔（24）的长边彼此面对。 每个孔（24）在壳体的外表面中设置有相应的不同开口。 每个孔（24）的开口在两个不同的平面中延伸，使得如果在由患者吸入期间至少一部分开口被覆盖在两个不同平面之一中，则在盖和孔之间产生空隙 （24），以便提供通过所述空隙空间到所述至少一个孔（24）的空气流动路径。