公开(公告)号：EP1223916B1

公开(公告)日：2004-09-22

申请号：EP00970729.0

申请日：2000-10-10

申请人： ALZA Corporation

发明人： HUANG, Shi, Kun ,  ZALIPSKY, Samuel ,  ZHANG, Wei-Ming ,  JIN, Bei ,  QUINN, Yolanda, P.

IPC分类号： A61K9/127

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K47/542 ,  A61K47/543 ,  A61K48/00 ,  C07D233/54 ,  C07D233/64 ,  Y10T428/2984

摘要： A lipid represented by formula (I), wherein each of R?1 and R2¿ is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n = 1-20; L is selected from the group consisting of (i) -X-(C=O)-Y-CH¿2?-, (ii) -X-(C=O)-, and (iii) -X-CH2-, wherein X and Y are independently selected from oxygen, NH and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

公开(公告)号：EP1446100A2

公开(公告)日：2004-08-18

申请号：EP02793941.2

申请日：2002-11-14

申请人： ALZA CORPORATION

发明人： CHEN, Guohua ,  HOUSTON, Paul, Ricky ,  KLEINER, Lothar, Walther ,  WRIGHT, Jeremy, Corwin

IPC分类号： A61K9/00

CPC分类号： A61K9/0024 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, an aromatic alcohol having miscibility in water of less than or equal to 7 wt.% at 25°C, in an amount effective to plasticize the polymer and form a gel therewith, and a beneficial agent. The composition may additionally contain an ester of an aromatic acid, or an aromatic ketone. The compositions are readily implanted beneath a patient's body surface by injection, as the aromatic alcohol not only facilitates solubilization of the polymer, but also acts as a thixotropic agent, substantially increasing the shear thinning behavior of the composition.

公开(公告)号：EP1150658B1

公开(公告)日：2004-08-04

申请号：EP00907183.8

申请日：2000-02-03

申请人： Alza Corporation

发明人： SLATER, James, L. ,  ZETTER, Adam, A. ,  ZHU, George, Z.

IPC分类号： A61K9/127 ,  A61K9/133

CPC分类号： A61K9/1277

摘要： A method of preparing liposomes to a selected particle size is described. In the method, a vesicle-forming lipid dissolved in a lipid solvent is hydrated with a second solvent to form a hydration mixture having greater than 10 and less than 50 weight percent of the lipid solvent. The target amount of lipid solvent in the lipid solvent is selected to obtain a desired particle size.

公开(公告)号：EP1393724A3

公开(公告)日：2004-03-17

申请号：EP03022248.3

申请日：1997-07-15

申请人： ALZA CORPORATION

发明人： Gale, Robert M. ,  Nelson, Melinda K. ,  Cormier, Michael J.N. ,  Gupta, Suneel K. ,  Campbell, Patricia S.

IPC分类号： A61K31/70 ,  A61K31/135

CPC分类号： A61K9/7084 ,  A61K31/135

摘要： A device for the transdermal administration of fluoxetine (10) at a therapeutically effective rate comprises: (a) a reservoir (12) containing a composition comprising an amount of a pharmaceutically acceptable salt of fluoxetine; (b) a backing (14) behind the body contacting-distal surface of the reservoir; and (c) means (16) for maintaining the reservoir in fluoxetine transmitting relation with a body surface or membrane.

公开(公告)号：EP1393724A2

公开(公告)日：2004-03-03

申请号：EP03022248.3

申请日：1997-07-15

申请人： ALZA CORPORATION

发明人： Gale, Robert M. ,  Nelson, Melinda K. ,  Cormier, Michael J.N. ,  Gupta, Suneel K. ,  Campbell, Patricia S.

IPC分类号： A61K31/138 ,  A61K9/70

CPC分类号： A61K9/7084 ,  A61K31/135

摘要： A device for the transdermal administration of fluoxetine (10) at a therapeutically effective rate comprises:

(a) a reservoir (12) containing a composition comprising an amount of a pharmaceutically acceptable salt of fluoxetine;
(b) a backing (14) behind the body contacting-distal surface of the reservoir; and
(c) means (16) for maintaining the reservoir in fluoxetine transmitting relation with a body surface or membrane.

摘要翻译： 用于以治疗有效速率透皮施用氟西汀（10）的装置包括：（a）含有一定量的药物可接受的氟西汀盐的组合物的储存器（12） （b）在容器的身体接触远侧表面后面的背衬（14）; 和（c）用于维持储存器与体表或膜的氟西汀传递关系的装置（16）。

公开(公告)号：EP1041968B1

公开(公告)日：2004-03-03

申请号：EP98963215.3

申请日：1998-12-15

申请人： Alza Corporation

发明人： AYER, Rupal

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

公开(公告)号：EP0836512B1

公开(公告)日：2004-03-03

申请号：EP96921500.3

申请日：1996-06-07

申请人： ALZA CORPORATION

发明人： PHIPPS, J., Bradley ,  LATTIN, Gary, A. ,  HAAK, Ronald, P. ,  THEEUWES, Felix ,  GUPTA, Suneel

IPC分类号： A61N1/32

CPC分类号： A61N1/325 ,  A61N1/044 ,  A61N1/0448

摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.

公开(公告)号：EP0909177B1

公开(公告)日：2004-02-11

申请号：EP97932237.7

申请日：1997-07-01

申请人： ALZA CORPORATION

发明人： ECKENHOFF, James, B. +di ,  STEVENSON, Cynthia, L. ,  TAO, Sally, A. ,  PRESTRELSKI, Steven, J. ,  WRIGHT, Jeremy, C. ,  LEONARD, Joe

IPC分类号： A61K38/04 ,  A61K38/08 ,  A61K38/09 ,  A61K38/24 ,  A61K47/08 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/02

CPC分类号： A61K38/09 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/20

公开(公告)号：EP1385479A1

公开(公告)日：2004-02-04

申请号：EP02733895.3

申请日：2002-03-26

申请人： Alza Corporation

发明人： ZALIPSKY, Samuel ,  ALLEN, Theresa, M.,University of Alberta ,  HUANG, Shi, Kun

IPC分类号： A61K9/127 ,  A61K9/133

CPC分类号： A61K9/1272 ,  A61K9/1271 ,  A61K47/6913

摘要： A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.

公开(公告)号：EP1383571A2

公开(公告)日：2004-01-28

申请号：EP02739170.5

申请日：2002-04-22

申请人： Alza Corporation

发明人： CORMIER, Michael, J. ,  DADDONA, Peter, E. ,  JOHNSON, Juanita, A. ,  YOUNG, Wendy, A. ,  MATRIANO, James, A. ,  KEENAN, Richard, L. ,  TRAUTMAN, Joseph, C.

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.