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公开(公告)号：EP4382137A1
公开(公告)日：2024-06-12
申请号：EP22853494.7
申请日：2022-08-04
发明人： YOO, Jeongsoo , KIM, Kyungwon
IPC分类号： A61K51/12
CPC分类号： A61K51/12 , A61P35/00 , C07B59/00 , C07C69/612 , C07C69/757 , C07C69/74 , C07C309/73 , C07C311/16 , C07C335/20 , C07D257/02
摘要： The present invention relates to a novel compound comprising an ester group and uses thereof and, more particularly, to a novel compound that exhibits excellent visualization ability in a tumor by using the difference in activity of esterase for each organ in the body, and to uses therefor for diagnosing or treating cancer. A novel compound of chemical Formulas 1 to 8 according to the present invention exhibits selectivity according to the difference in activity of esterase for each organ due to ester residue in a structure, and thus is extremely effective in visualizing pancreatic cancer, etc.
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公开(公告)号：EP4374881A1
公开(公告)日：2024-05-29
申请号：EP22846281.8
申请日：2022-07-21
发明人： CHANG, Yong Min , SUNG, Bo Kyung
IPC分类号： A61K49/10
CPC分类号： A61K49/10
摘要： A gadolinium-based compound and an MRI contrast agent comprising same are disclosed. The gadolinium-based compound may be a DO3A-based gadolinium compound bound to protocatechuic acid. The MRI contrast agent may comprise the compound. In addition, disclosed is a pharmaceutical composition for preventing or treating neuroinflammatory diseases, comprising the compound or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4296346A1
公开(公告)日：2023-12-27
申请号：EP22891172.3
申请日：2022-11-11
申请人： Kyungpook National University Industry-Academic Cooperation Foundation , Kyungpook National University Hospital
发明人： HAN, Hyungsoo , LEE, Youngmi , BAE, Mijung
IPC分类号： C12M1/00
摘要： The present invention relates to a portable device for isolating nucleic acid from blood.
The portable device for isolating nucleic acid from blood according to the present invention includes a body, a channel that is formed on an upper surface of the body in a groove shape with a set standard and provides a path for moving the blood, a pair of platinum wires of which ends are in contact with both ends of the channel, and a battery of which both electrodes are connected to the other ends of the pair of platinum wires and which provides an electrical force, wherein the blood dropped into the channel in contact with the platinum wire connected to a negative electrode of the battery is moved toward the channel in contact with the platinum wire connected to a positive electrode of the battery due to the electrical force provided by the battery so that the nucleic acid is isolated from the blood.-
84.发明公开
公开(公告)号：EP4234578A1
公开(公告)日：2023-08-30
申请号：EP21883129.5
申请日：2021-10-14
发明人： KIM, Soyoun , YOO, Jae Do , JEON, In Seon , KIM, Min-Seong , LEE, Byung-Heon
摘要： The present invention relates to a ferritin nanocage fused with PD-L1-binding peptide 1 and a use thereof as an anticancer immunotherapy agent. Prepared in the present invention were nanocages that are formed by fusing a human ferritin monomer with a peptide 1 (PD-L1pep1: CLQKTPKQC) binding to the immune checkpoint receptor PD-L1 overexpressed in many cancers such as breast cancer, colorectal cancer, renal cancer, glioblastoma, etc. and which display 24 Pd-L1prep1. The nanocages of the present invention effectively target colorectal cancer tissues to exhibit an anticancer effect. When loading the anticancer agent doxorubicin thereinto, the nanocages showed higher anticancer effects than the same dose of PD-L1 antibody. Accordingly, the nanocages are expected as a next-generation drug that surmounts the limitation of immune checkpoint blocking therapy using antibodies.
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公开(公告)号：EP4219510A1
公开(公告)日：2023-08-02
申请号：EP21886596.2
申请日：2021-10-05
发明人： CHANG, Yong Min , BAEK, Ah Rum
摘要： The present invention relates to a novel compound and an MRI contrast agent containing same. The compound according to the present invention can minimize MRI contrast agent side effects caused by the release of gadolinium ions within the body, on the basis of the outstanding kinetic stability, and can be very usefully employed as an MRI contrast agent for diagnosing liver diseases, owing to the superior level of contrast enhancement for the liver in an MRI image of the body in comparison with other organs.
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公开(公告)号：EP4166544A1
公开(公告)日：2023-04-19
申请号：EP20939608.4
申请日：2020-08-25
申请人： Etnova Therapeutics Corp. , Kyungpook National University Industry-Academic Cooperation Foundation
IPC分类号： C07D257/02 , A61K31/395 , A61P25/00 , A61P25/28
摘要： The present invention relates to a compound of formula 1 and a pharmaceutical composition containing same. This compound may be useful as: a therapeutic agent for degenerative brain diseases including dementia or cranial nerve diseases and developmental disorders caused by neural cell damage, various degenerative neural diseases, ischemic nerve diseases, or neural damage diseases; a learning ability-improving agent; and a cognitive function-improving agent. [Formula 1] in formula 1 above, B represents a part derived from retinoic acid.
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87.发明公开
公开(公告)号：EP4070782A3
公开(公告)日：2022-10-19
申请号：EP22165220.9
申请日：2022-03-29
IPC分类号： A61K8/98 , A61P17/14 , A61Q7/00 , A61K35/15 , C12N5/0786
摘要： The present invention relates to a composition for hair regeneration comprising a macrophage-derived extracellular vesicle mimetics, and since macrophage-derived extracellular vesicle mimetics are well absorbed into dermal papilla cells, have an excellent effect in promoting the proliferation of dermal papilla cells, as well as having an activity to increase the level of hair-induced proteins, it is excellent in the effects of proliferation of dermal papilla cells and hair increase and thus a composition comprising macrophage-derived extracellular vesicle mimetics can be provided for hair regeneration.
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88.发明公开
公开(公告)号：EP4070782A2
公开(公告)日：2022-10-12
申请号：EP22165220.9
申请日：2022-03-29
摘要： The present invention relates to a composition for hair regeneration comprising a macrophage-derived extracellular vesicle mimetics, and since macrophage-derived extracellular vesicle mimetics are well absorbed into dermal papilla cells, have an excellent effect in promoting the proliferation of dermal papilla cells, as well as having an activity to increase the level of hair-induced proteins, it is excellent in the effects of proliferation of dermal papilla cells and hair increase and thus a composition comprising macrophage-derived extracellular vesicle mimetics can be provided for hair regeneration.
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89.发明公开
公开(公告)号：EP3910008A1
公开(公告)日：2021-11-17
申请号：EP20739181.4
申请日：2020-01-13
发明人： YOO, Jeong Soo , LEE, Woong Hee , PARK, Wonchoul
IPC分类号： C08J3/28 , C08J3/24 , C08J3/12 , C08L5/08 , A61K51/12 , A61K8/67 , A61K8/73 , A61Q19/00 , A61K47/69
摘要： The present invention relates to a method for preparing cross-linked hyaluronic acid nanoparticles, comprising forming intermolecular or intramolecular cross-linking by irradiating a hyaluronic acid aqueous solution with an electron beam. There are provided uses of synthesized hyaluronic acid nanoparticles as a contrast agent for tumor diagnosis and a therapeutic agent through the skin permeability confirmed by fluorescence labeling and radioactive labeling by uniformly synthesizing hyaluronic acid nanoparticles having various nano-meter sizes reproducibly under an optimized electronic beam condition.
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公开(公告)号：EP3875092A1
公开(公告)日：2021-09-08
申请号：EP19878702.0
申请日：2019-10-30
发明人： PARK, Dong Ho , LEE, In Kyu
IPC分类号： A61K31/506 , A61K9/00 , A61P27/02 , A23L33/10
摘要： The present disclosure pertains to a pharmaceutical composition comprising fursultiamine or a salt thereof for prevention or treatment of macular degeneration. Fursultiamine decreases the upregulated expression of HIF-1α in retinal pigment epithelial cells and suppresses the growth of choroidal vascular endothelial cells. The pharmaceutical composition comprising fursultiamine or salts thereof according to the present disclosure can be used as a therapeutic agent for various neovascular ocular diseases.
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