利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

174 条记录 (耗时 0.028 秒)

    Anti-GM-CSF Antibodies and uses therefor
    85.
    发明公开
    Anti-GM-CSF Antibodies and uses therefor 审中-公开
    抗GM-CSF抗体及其用途

    公开(公告)号：EP2468773A2

    公开(公告)日：2012-06-27

    申请号：EP11187236.2

    申请日：2006-05-17

    申请人： MorphoSys AG

    发明人： Steidl, Stefan ,  Thomassen-Wolf, Elisabeth

    IPC分类号： C07K16/24

    CPC分类号： C07K16/243 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

    摘要： The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    摘要翻译： 本发明提供了特异于GM-CSF的重组抗原结合区，抗体及其功能片段，其在各种病症或病症中起着不可缺少的作用。 因此，这些抗体可用于治疗例如类风湿性关节炎等炎症性疾病。 本发明的抗体也可用于诊断领域，以及用于进一步研究GM-CSF在各种疾病进展中的作用。 本发明还提供编码前述抗体的核酸序列，含有其的载体，药物组合物和具有使用说明书的试剂盒。

    DISPLAY VECTORS AND METHODS AND USES THEREOF
    90.
    发明公开
    DISPLAY VECTORS AND METHODS AND USES THEREOF 审中-公开
    展示载体和方法和用途

    公开(公告)号：EP2235181A1

    公开(公告)日：2010-10-06

    申请号：EP09700624.1

    申请日：2009-01-09

    申请人： MorphoSys AG

    发明人： ENZELBERGER, Markus ,  YODER, Stephen ,  NEUN, Rüdiger ,  THIEL, Philippe ,  PETERS, Solveig

    IPC分类号： C12N15/79

    CPC分类号： C12N15/1037

    摘要： The present invention relates, in one aspect, to a vector comprising (a) a first polynucleotide capable of encoding a first (poly)peptide comprising at least one cysteine residue, and (b) a second polynucleotide capable of encoding a second (poly)peptide which is a cell surface anchor comprising at least one cysteine residue, wherein the vector is operable in a eukaryotic host cell to express and to cause or allow the attachment of said first (poly)peptide to said second (poly)peptide by formation of a disulfide bond between said cysteine residues comprised within said first (polypeptide and said second (poly)peptide, respectively, wherein said first (poly)peptide is exhibited at the surface of a eukaryotic host cell.