公开(公告)号：EP2508888A1

公开(公告)日：2012-10-10

申请号：EP12174981.6

申请日：2008-11-28

申请人： National University Corporation Hokkaido University ,  Shionogi & Co., Ltd.

发明人： Nishimura, Shin-ichiro ,  Todo, Satoru

IPC分类号： G01N33/576

CPC分类号： G01N33/576 ,  G01N2800/085

摘要： It is intended to provide a novel diagnosis method for a hepatic disease, in particular, HCC. A serum sugar chain usable as a novel biomarker is provided by analyzing the relationship between the quantitative expression profiles of sugar chains in the serum and individual disease conditions and thus finding a sugar chain showing a change with the progression of a hepatic disease.

摘要翻译： 旨在为肝脏疾病，特别是肝癌提供一种新的诊断方法。 通过分析血清中糖链的定量表达谱与个体病情之间的关系，提供可用作新型生物标志物的血清糖链，从而发现随着肝病发展而呈现变化的糖链。

公开(公告)号：EP2241892B1

公开(公告)日：2012-08-08

申请号：EP08868616.7

申请日：2008-12-24

申请人： National University Corporation Hokkaido University

发明人： KOIKE, Takao, c/o National University Corporation ,  NISHIO, Mitsufumi, c/o National University Corporation ,  NISHIHARA, Hiroshi, c/o National University Corporation

IPC分类号： G01N33/574 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： G01N33/57426 ,  G01N2333/70596

摘要： [PROBLEMS] To provide a marker which is useful in diagnosing leukemia and a method of using the same. [MEANS FOR SOLVING PROBLEMS] A method of detecting a leukemic cell which comprises detecting a CD34-positive cell being negative in DOCK180 expression from a blood specimen. According to this method, a DOCK180 expression pattern specific to a tumor cell in leukemia, in particular, acute leukemia is confirmed so that information which is useful in diagnosing leukemia and monitoring and determining the severity and degree of recovery of the same by a doctor can be obtained by a convenient procedure using blood specimens and thus provided.

公开(公告)号：EP2481808A1

公开(公告)日：2012-08-01

申请号：EP10818555.4

申请日：2010-09-22

申请人： National University Corporation Hokkaido University ,  Shionogi & Co., Ltd.

发明人： MITSUTAKE, Susumu ,  IGARASHI, Yasuyuki ,  ZAMA, Kota ,  YOSHIDA, Tetsuya ,  TANAKA, Yoshikazu ,  TAKEMOTO, Hiroshi

IPC分类号： C12Q1/48 ,  C12N5/10 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68 ,  C12N15/09

CPC分类号： C12Q1/48 ,  G01N2333/9129 ,  G01N2800/044

摘要： Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.

摘要翻译： 本发明公开了一种筛选的药剂也可以减少体重的方法，药剂确实可以减少内脏脂肪，药剂确实能减少肝脏甘油三酯和药剂也可以改善肥胖和脂肪肝 ， 该方法包括测量在鞘磷脂合酶的候选物质的抑制活性，worin所述候选物质的步骤是确定性的开采具有选自抗肥胖剂中的至少一种功能，内脏脂肪减少剂， 脂肪肝处理剂和体脂联素表达增强剂当候选物质具有对鞘磷脂合酶抑制活性。

公开(公告)号：EP2476311A1

公开(公告)日：2012-07-18

申请号：EP10815378.4

申请日：2010-09-08

申请人： Forestry And Forest Products Research Institute ,  The University of Electro-Communications ,  National University Corporation Hokkaido University

发明人： TAKANASHI Takuma ,  OHMURA Wakako ,  OHYA Eiji ,  KUBOJIMA Yoshitaka ,  MORI Teruo ,  KOIKE Takuji ,  NISHINO Hiroshi

IPC分类号： A01M1/00 ,  A01M1/02 ,  A01M29/00

摘要： A method for controlling an insect pest with vibrations, including a step of determining a frequency range and an amplitude range of vibrations in a habitat medium of an insect pest that induce or suppress a specific behavior of the insect pest, and a step of controlling the insect pest behavior by applying vibrations in the frequency range and amplitude range once or two or more times in the insect pest habitat medium.

公开(公告)号：EP2051411B1

公开(公告)日：2012-03-07

申请号：EP06782348.4

申请日：2006-08-04

申请人： Mitsubishi Electric Corporation ,  National University Corporation Hokkaido University

发明人： NISHIOKA, Tsuyoshi ,  HASEGAWA, Toshio ,  ABE, Junnichi ,  TAKEUCHI, Shigeki c/o National University Corporation Hokkaido University ,  SOUJAEFF, Alexandre c/o National University Corporation Hokkaido University

IPC分类号： H04B10/00 ,  H04L9/12

CPC分类号： H04L9/0852 ,  H04B10/70

摘要： To accomplish a stable quantum communication having a high efficiency without being affected by the jitters of messenger signals. In a quantum encryption transmitter apparatus (200), a pulse-driven messenger single-photon source (201) generates a pair of photons, one of which is outputted as a quantum signal and the other of which is outputted as a messenger signal. A timing adjuster (202) outputs the messenger signal, as a trigger signal, in synchronism with a clock signal used to pulse drive the pulse-driven messenger single-photon source (201). A quantum signal modulating part (203) modulates the quantum signal in accordance with the timing of the trigger signal, and transmits the modulated quantum signal to a quantum encryption receiver apparatus (300) via a quantum communication path (101). A messenger signal transmitting part (205) transmits the messenger signal to the quantum encryption receiver apparatus (300) via a messenger signal communication part (102). A clock signal transmitting part (206) transmits the clock signal to the quantum encryption receiver apparatus (300) via a clock communication part (103).

公开(公告)号：EP2423685A1

公开(公告)日：2012-02-29

申请号：EP11172241.9

申请日：2008-12-05

申请人： Immuno-Biological Laboratories Co., Ltd. ,  National University Corporation Hokkaido University

发明人： Maeda, Masahiro ,  Seito, Tsutomu ,  Suzuki, Toshiharu ,  Hata, Saori

IPC分类号： G01N33/53 ,  C07K14/705 ,  C07K16/28 ,  A61K45/00 ,  A61P25/28

CPC分类号： G01N33/6896 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  G01N2333/96419 ,  G01N2800/2821

摘要： Disclosed are: an agent, an apparatus and a method for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for providing information for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for monitoring the condition or the degree of progression of a disease associated with the abnormality in γ-secretase; and a method for determining the therapeutic effect of a therapeutic agent on a disease associated with the abnormality in γ-secretase. More specifically disclosed are: a diagnostic agent for a disease associated with the abnormality in γ-secretase, which comprises an antibody capable of recognizing a digestion product of an alcadein with α-secretase or γ-secretase or a fragment of the antibody; and others.

摘要翻译： 公开的是：用于诊断与分泌酶异常有关的疾病的药剂，装置和方法; 提供用于诊断与分泌酶异常有关的疾病的信息的方法; 用于监测与分泌酶异常有关的疾病的状况或进展程度的方法; 以及用于确定治疗剂对与分泌酶异常相关的疾病的治疗效果的方法。 更具体地公开了：与分泌酶异常相关的疾病的诊断剂，其包含能够识别具有±分泌酶或β-分泌酶或抗体片段的alcadein的消化产物的抗体; 和别的。

公开(公告)号：EP2281628A3

公开(公告)日：2011-09-28

申请号：EP10251392.6

申请日：2010-08-04

申请人： Sumitomo Chemical Company, Limited ,  National University Corporation Hokkaido University

发明人： Abe, Ryu ,  Kanome, Naoko ,  Sogabe, Kohei ,  Sakatani, Yoshiaki

IPC分类号： B01J23/42 ,  B01J23/44 ,  B01J23/46 ,  B01J23/50 ,  B01J23/52 ,  B01J23/648 ,  B01J23/652 ,  B01J23/847 ,  B01J23/888 ,  B01J35/00 ,  B01J37/02 ,  B01J37/34

CPC分类号： B01J35/004 ,  B01J23/42 ,  B01J23/44 ,  B01J23/46 ,  B01J23/462 ,  B01J23/464 ,  B01J23/468 ,  B01J23/50 ,  B01J23/52 ,  B01J23/6484 ,  B01J23/6527 ,  B01J23/8474 ,  B01J23/888 ,  B01J37/0201 ,  B01J37/34

摘要： A method for producing a photocatalytic, which can produce a photocatalyst showing high photocatalytic activity, is provided.
The present invention relates to a method for producing noble metal-supported photocatalyst particles wherein a noble metal is supported on the surface of the photocatalyst particles, and a method for producing a dispersion of the noble metal-supported photocatalyst particles, the methods comprising steps of: blowing an inert gas into a raw dispersion in which the photocatalyst particles are dispersed and a precursor of the noble metal is dissolved in a dispersion medium; and irradiating the raw dispersion with light having energy larger than that of a bandgap of the photocatalyst particles, thereby supporting the noble metal on the surface of the photocatalyst particles.

公开(公告)号：EP1189364B8

公开(公告)日：2011-09-21

申请号：EP00940798.2

申请日：2000-06-22

申请人： National University Corporation Hokkaido University ,  SANYO ELECTRIC CO., LTD.

发明人： OGAWA, Yasutaka c/o Hokkaido University ,  OHGANE, Takeo c/o Hokkaido University ,  DOI, Yoshiharu c/o Sanyo Electric Co., Ltd.

IPC分类号： H04B7/10 ,  H04B7/08 ,  H04B7/06 ,  H01Q3/26

CPC分类号： H04B7/0848 ,  H01Q1/246 ,  H01Q3/2605 ,  H04B7/0615 ,  H04B7/0851

摘要： A radio device (1000) separates the signal from a specific terminal among from the signals from adaptive array antennas (#1 to #4) according to a reception weight vector calculated by a reception weight vector calculator (20). A reception coefficient vector calculator (22) derives an impulse response of a propagation path of the signal from the specific signal. A transmission coefficient vector inferring device (32) predicts the propagation path at the transmission time from the results of the inference by the reception coefficient vector (22). A transmission weight vector calculator (30) controls the antenna directivity at the transmission time according to the results of the prediction by the transmission coefficient vector inferring device (32). In such a way, the degradation of the error rate of the downstream line due to time difference between the upstream and downstream lines can be suppressed.

摘要翻译： 无线电设备（1000）根据由接收权重矢量计算器（20）计算的接收权重矢量，从来自自适应阵列天线（＃1至＃4）的信号中分离来自特定终端的信号。 接收系数矢量计算器（22）从特定信号中导出信号传播路径的脉冲响应。 透过系数矢量推定器（32）根据接收系数矢量（22）的推断结果，预测发送时的传播路径。 发送权重矢量计算器（30）根据透过系数矢量推定器（32）的预测结果，控制发送时的天线指向性。 以这种方式，可以抑制由于上游线和下游线之间的时间差引起的下游线路的错误率的劣化。

公开(公告)号：EP2365338A1

公开(公告)日：2011-09-14

申请号：EP11157639.3

申请日：2011-03-10

申请人： Fujifilm Corporation ,  National University Corporation Hokkaido University

发明人： Adachi, Takashi ,  Ogikubo, Shinya ,  Ohta, Nobuhiro ,  Nakabayashi, Takakazu

IPC分类号： G01N33/84

CPC分类号： G01N33/84 ,  A61B5/0068 ,  A61B5/0071 ,  G01N21/6408 ,  G01N21/6486

摘要： It is possible to highly accurately measure the oxygen concentration of a substance to be measured without being influenced by the intensity of excitation light (L1), the concentration of fluorescent material, and the surrounding environment. Pulsed excitation light (L1) including a wavelength that can excite a fluorescent material contained in living matter is generated. The fluorescence lifetime (Tf) of the fluorescent material is longer than or equal to 4.8 nanoseconds. A predetermined position in the living matter is illuminated with the pulsed excitation light (L1). Further, light including fluorescence (Lf) emitted from the fluorescent material excited by illumination with the pulsed excitation light (L1) is received. The lifetime (Tf) of the fluorescence (Lf) included in the received light is calculated by time-resolving the intensity of the fluorescence (Lf) . Further, the oxygen concentration of the living matter is measured based on the lifetime (Tf)

摘要翻译： 因此能够高度准确地设定测量物质中的氧浓度而不受激发光的强度（L1）荧光材料，浓度，和周围环境的影响进行测量。 脉冲激发光（L1），其包括波长确实可以激发包含在生命物质产生的荧光材料。 荧光材料的荧光寿命（TF）是长于或等于4.8毫微秒。 在生命物质的预定位置与所述脉冲的激发光（L1）照射。 此外光包括来自通过照明用脉冲的激发光（L1）激发的荧光材料发出的荧光（LF）被接收。 的荧光的寿命（TF）（LF）包括在接收到的光通过时间分辨荧光（LF）的强度来计算。 此外，的生命物质中的氧浓度是基于寿命测定（TF）

公开(公告)号：EP2365336A1

公开(公告)日：2011-09-14

申请号：EP11157637.7

申请日：2011-03-10

申请人： Fujifilm Corporation ,  National University Corporation Hokkaido University

发明人： Adachi, Takashi ,  Ogikubo, Shinya ,  Ohta, Nobuhiro ,  Nakabayashi, Takakazu

IPC分类号： G01N33/84

CPC分类号： G01N33/84 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/6852 ,  G01N21/6408

摘要： The pH of a substance to be measured is accurately measured without being influenced by the intensity of excitation light (L1), the concentration of fluorescent material and surrounding environments. The pH is measured by generating pulsed excitation-light (L1) including a wavelength that can excite a plurality of kinds of fluorescent-material in living matter that act as coenzyme in oxidation/reduction reaction in vivo, and the intensity of the light not damaging a tissue nor a cell and substantially not changing pH, and by illuminating a predetermined position in the living matter with the light (L1), and by receiving fluorescence (Lf), and by resolving the intensity of the fluorescence (Lf) into time domains the number of which is greater than that of the fluorescent-material, and by detecting the intensities of the fluorescence (Lf) in the respective time domains, and by obtaining approximate-curves having gradients unique to the fluorescent-materials based on the intensities in the respective time domains, and by calculating fluorescence lifetimes (Tf) of at least two of the plurality of kinds of fluorescent-material based on the approximate-curves, and by measuring the pH of the living matter based on the lifetimes (Tf).

摘要翻译： 的物质的被测量测得的pH值被精确地设定，不受激发光的强度（L1），荧光材料和周围环境的浓度的影响。 pH通过产生脉冲激励光（L1），其包括波长测量确实能够激发种荧光材料的的多个生命物质做充当在体内氧化/还原反应的辅酶，并且光的强度不损坏 的组织也不是细胞且基本上不改变pH，并通过照射与光（L1）的生命物质的预定位置，并且通过接收荧光（LF），以及通过解析荧光（LF）的强度成时间区域 的所有的数量是大于使荧光材料制成，并通过在respectivement时间域检测荧光（LF）的强度，并且通过获得具有独特的基于强度的荧光材料梯度近似曲线 所述respectivement时间域，并且通过计算荧光寿命（TF）至少两种基于近似曲线荧光材料的多个的，并且通过测量的pH值 在生命的物质基础上的寿命（TF）。