公开(公告)号：EP2145597A1

公开(公告)日：2010-01-20

申请号：EP08761547.2

申请日：2008-04-30

申请人： Universidad de Barcelona ,  Universidad de Zaragoza

发明人： BURDIO PINILLA, Fernando ,  GÜEMES SÁNCHEZ, Antonio

IPC分类号： A61B18/18

CPC分类号： A61B18/148 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00601 ,  A61B2018/1412

摘要： A monopolar electrosurgical instrument comprising a cylindrical metallic electrode which is connected to one pole of a radio frequency generator on one extreme; said electrode comprising a liquid supply for cooling, a handle 7 that covers part of the electrode, a part 6 covered with an insulative material, and a coagulating and cutting uninsulated tip; said tip comprising a round ending part 2 , a part 3 attached to a cutting metal blade 5 near the end, and a part 4 non-attached to a cutting metal blade. It is useful for precisely cut the tissue that it is previously coagulated, using a single instrument, and avoiding risk of bleeding.

摘要翻译： 一种单极电外科器械，包括圆柱形金属电极，其一端与射频发生器的一极连接; 所述电极包括用于冷却的液体供应源，覆盖电极的一部分的手柄7，被绝缘材料覆盖的部分6以及凝固切割未绝缘尖端; 所述尖端包括圆形端部2，附接到切割金属叶片5附近的部分3以及未附接到切割金属叶片的部分4。 使用单个仪器精确切割预先凝固的组织是有用的，并避免出血的风险。

公开(公告)号：EP2143394A2

公开(公告)日：2010-01-13

申请号：EP08761543.1

申请日：2008-04-30

申请人： Universidad Politecnica De Valencia ,  Universidad de Zaragoza

发明人： BERJANO ZANÓN, Enrique ,  BURDIO PINILLA, Fernando ,  GÜEMES SÁNCHEZ, Antonio ,  NAVARRO GONZALO, Ana

IPC分类号： A61B18/14

CPC分类号： A61B18/14 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/1497 ,  A61B2218/002

摘要： An applicator device (1,1) for radiofrequency ablation of biological tissues; the device comprises an electrode whose outer surface is covered with an insulating cover (2, 2") in a proximal portion, and has a conductive distal portion (3,3') whose electrode includes internal refrigeration means (7,7'); an infusion system with a distal end (13, 6) for infusing a fluid in said tissue; wherein said distal end (13, 6) of the infusion system has an electrically insulating outer cover and is located, in the infusion position for said fluid, at a distance between 2 and 5 millimetres from said outer surface of the internally cooled electrode. The invention also concerns a method for ablation by radiofrequency of biological tissues.

摘要翻译： 一种用于生物组织射频消融的敷贴器（1,1）; 该装置包括其外表面在近端部分被绝缘盖（2,2“）覆盖的电极，并且具有其电极包括内部制冷装置（7,7'）的导电远端部分（3,3'）; 输液系统，其具有用于在所述组织中注入流体的远端（13,6）;其中所述输注系统的所述远端（13,6）具有电绝缘的外盖，并且位于所述流体的输液位置 距离内部冷却电极的外表面距离2至5毫米的距离，本发明还涉及通过生物组织的射频消融的方法。

公开(公告)号：EP1371375B1

公开(公告)日：2009-08-19

申请号：EP02702414.0

申请日：2002-02-21

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  Universidad de Zaragoza ,  LABORATORIOS HIPRA, S.A.

发明人： LARRAGA RODRIGUEZ DE VERA, V. E. Ctro. Inv. Biolo. ,  GONZALEZ ASEGUINOLAZA, G. Ctro. Inv. Biolo. ,  RAMIRO IBANEZ, M. J. Ctro. Inv. Biolo. ,  CASTILLO HERNANDEZ, J. A. Univ. de Zaragoza ,  LUCIENTES CURDI, J. Universidad de Zaragoza

IPC分类号： A61K39/008 ,  C07K14/44 ,  C12N15/30 ,  C12N15/26 ,  C12N15/863

CPC分类号： C07K14/44 ,  A61K38/208 ,  A61K39/00 ,  A61K39/008 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55538 ,  A61K2039/57 ,  C12N2799/021 ,  Y02A50/41 ,  A61K2300/00

摘要： The present invention is generally related to the prevention of leishmaniasis in animals, particularly infection caused by Leishmania sp., based on the use of Leishmania infantum P36 protein or an immunogenic fragment of the latter, or involving an expression system for the mentioned protein or fragment - optionally in combination with a compound stimulating the production of a Th1-type cellular immune response - and comprising various vaccination protocols in application to Leishmania sp. based on the mentioned vaccine.

公开(公告)号：EP1550673A1

公开(公告)日：2005-07-06

申请号：EP03795029.2

申请日：2003-08-13

申请人： UNIVERSIDAD DE ZARAGOZA

发明人： SARASA BARRIO, Manuel

IPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  G01N33/68

CPC分类号： C07K14/4711 ,  C07K16/18 ,  G01N33/6896

摘要： Polyclonal antibodies,preparation method thereof and use of same. The invention relates to polyclonal antibodies which specifically recognize, and have a strong affinity with, the two most significant amyloid peptides, Aβ40 and Aβ42. The invention also relates to the use thereof in assessing drugs which activate the degradation of amyloid peptides characteristic of Alzheimer's disease as well as drugs which inhibit the formation of same.

摘要翻译： 多克隆抗体及其制备方法及用途。 本发明涉及与两种最重要的淀粉样蛋白Aβ40和Aβ42特异性识别并具有强亲和力的多克隆抗体。本发明还涉及其在评估激活淀粉样蛋白肽降解的药物中的用途 阿尔茨海默病的特征以及抑制其形成的药物。