公开(公告)号：EP0874833A1

公开(公告)日：1998-11-04

申请号：EP96944274.0

申请日：1996-12-12

申请人： HOECHST MARION ROUSSEL, INC.

发明人： HRIB, Nicholas, J.

IPC分类号： A61K31 ,  A61P1 ,  A61P25 ,  A61P43 ,  C07D261 ,  C07D413 ,  C07D451 ,  C07D453

CPC分类号： C07D413/12 ,  C07D261/20 ,  C07D413/14 ,  C07D453/02

摘要： 4,5-Dihydronaphth[1,2-c]isoxazole derivatives of general formula (I), where A, X and n are defined herein are disclosed. Such compounds are useful as serotonin 5-HT3 antagonists. These compounds are useful for the treatment of anxiety, psychiatric disorders, nausea, vomiting and drug dependency.

公开(公告)号：EP0872465A2

公开(公告)日：1998-10-21

申请号：EP98106472.8

申请日：1995-09-18

申请人： HOECHST MARION ROUSSEL, INC.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07C17/16 ,  C07C25/24 ,  C07C231/08 ,  C07C233/90 ,  C07C209/62 ,  C07C211/29

CPC分类号： C07C17/16 ,  C07C25/24 ,  C07C29/147 ,  C07C33/483 ,  C07C69/65 ,  C07C211/29 ,  C07C233/13

摘要： The present invention relates to a novel process for preparing alkali metal salts of diformylamide, and a novel crystalline form of sodium diformylamide.

摘要翻译： 本发明涉及一种制备二酰胺的碱金属盐的新方法，以及二甲酰胺钠的新结晶形式。

公开(公告)号：EP0716093B1

公开(公告)日：1998-10-21

申请号：EP95402744.7

申请日：1995-12-06

申请人： HOECHST MARION ROUSSEL

发明人： Agouridas, Constantin ,  Chantot, Jean-François

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  A61K31/70 ,  Y02A50/478

公开(公告)号：EP0869946A1

公开(公告)日：1998-10-14

申请号：EP96942431.0

申请日：1996-12-19

申请人： HOECHST MARION ROUSSEL

发明人： CLAUSSNER, André ,  GOUBET, François ,  TEUTSCH, Jean-Georges

IPC分类号： A61K31 ,  A61P13 ,  A61P17 ,  A61P43 ,  C07D233

CPC分类号： C07D233/78

摘要： Products of formula (I), wherein R1 and R2 are particularly cyano and trifluoromethyl, R3 is particularly alkyl, alkenyl or alkynyl optionally substituted by nitrooxy or carbonyloxy, R4 and R5 are particularly methyl optionally substituted by fluorine, and X and Y are particularly oxygen, as well as salts and isomers thereof, are disclosed.

公开(公告)号：EP0869121A1

公开(公告)日：1998-10-07

申请号：EP98105256.6

申请日：1998-03-24

申请人： Hoechst Marion Roussel Deutschland GmbH

发明人： Glombik, Heiner, Dr. ,  Enhsen, Alfons, Dr. ,  Kramer, Werner, Dr. Dr. ,  Baringhaus, Karl-Heinz, Dr.

IPC分类号： C07D213/74 ,  A61K31/44 ,  C07D213/38 ,  C07D409/12 ,  C07D213/80 ,  C07D401/12 ,  C07D417/12 ,  C07D411/12

CPC分类号： C07D213/74 ,  C07D213/80 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： Die Erfindung betrifft substituierte Propanolaminderivate und deren Säureadditionssalze.
Es werden Propanolaminderivate der Formel I,
worin R 1 bis R 8 die angegebenen Bedeutungen haben, sowie deren physiologisch verträglichen Salze und Verfahren zu deren Herstellung beschrieben. Die Verbindungen eignen sich z.B. als Hypolipidämika.

摘要翻译： 式（I）的N-3-二取代1,2-二（异）芳基-3-氨基丙醇衍生物及其酸加成盐是新的。 R 1，R 2 = 3-8C环烷基，苯基，萘基，吩噻嗪基，吡啶基，噻吩基，呋喃基，嘧啶基，吲哚基，噻唑基，咪唑基，香豆素基，苯二甲酰亚氨基，喹啉基，哌嗪基，四唑基，三唑基，恶唑基或其噻吩并 - ，吡啶并 - 苯并稠合衍生物（全部由F，Cl，Br，I，OH，CF 3，NO 2，CN，1-8C烷基，1-8C烷氧基，NH 2，NHR 9，NR 9 R 10，CHO，COOH，COOR 11 ，COR12，-Q-OH，-Q（OH）-Ph，-Q-CF3，-Q-NO2，-Q-CN，-Q-NH2，-Q-NHR9，-Q-NR9R10，-Q- ，-Q-COOH，-Q-COOR11，-Q-COR12，-OQ-OH，-OQ-CF3，-OQ-NO2，-OQ-CN，-OQ-NH2，-OQ-NHR9，-OQ-NR9R10 ，-OQ-CHO，-OQ-COOH，-OQ-COOR11，-OQ-COR12，-N-SO3H（sic），SO2Me和-OQOQ-苯基）; Q = 1-6C亚烷基; R3-R8 = H，卤素，CF3，NO2，CN，1-8C烷氧基，1-8C烷基，NH2，NHR9，NR9R10，CHO，COOH，COOR11或COR12; R9-R12 = H或1-8C烷基; X，Y = CH或N; 并且所有烷基和亚烷基任选被一个或多个F取代; 条件是（I; R1，R2 = Ph;和X，Y = CH）被排除。

公开(公告)号：EP0863878A1

公开(公告)日：1998-09-16

申请号：EP96928900.0

申请日：1996-08-15

申请人： HOECHST MARION ROUSSEL, INC.

发明人： THOMAS, Craig, E. ,  FEVIG, Thomas, L. ,  BOWEN, Stephen, M. ,  FARR, Robert, A. ,  CARR, Albert, A. ,  JANOWICK, David, A.

IPC分类号： A61K31 ,  A61P39 ,  C07D209 ,  C07D217 ,  C07D221 ,  C07D223 ,  C07D491 ,  C07D495

CPC分类号： C07D221/20 ,  C07D209/44 ,  C07D217/08 ,  C07D217/24 ,  C07D221/10 ,  C07D223/14 ,  C07D223/16 ,  C07D491/04 ,  C07D491/10 ,  C07D495/04

摘要： The present invention is directed to novel cyclic nitrones of the formula (I) in which R1 and R2 are each independently represented by a C1-3 alkyl or R1 and R2 together form a C5-6 alkylene ring or a ring of structure (a), Z represents (CHx)n, wherein x and n are independently 0 or an integer from 1-2; R3 is represented by a substituent selected from the group consisting of hydrogen, C1-4 alkyl, OH, OAc or (b); and the ring represented by X is a substituent selected from the group consisting of (c), (d), (e) or (f) wherein the area of dark shading represents the side of attachment to the nitrone ring, R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, C1-3 alkyl, OH or C1-3 alkoxy and the pharmaceutically acceptable salts thereof, with the proviso that when R1 and R2 together form a C5-6 alkylene ring and n is 1, then R3 cannot be hydrogen and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.

公开(公告)号：EP0863760A1

公开(公告)日：1998-09-16

申请号：EP96931876.0

申请日：1996-09-19

申请人： HOECHST MARION ROUSSEL

发明人： PETIT, Francis ,  PHILIBERT, Daniel ,  GOEDERS, Nick

IPC分类号： A61K45 ,  A61K31 ,  A61P25

CPC分类号： A61K31/58 ,  A61K31/585

摘要： Compounds having antimineralocorticoid activity suitable for preparing drugs for treating or preventing conditions related to drug dependence or to the spontaneous or induced withdrawal syndrome caused by narcotics or mixtures thereof, and compositions containing same, are disclosed.

摘要翻译： 披露了具有抗盐皮质激素活性的化合物，所述化合物适用于制备用于治疗或预防药物依赖性相关病症或由麻醉药或其混合物引起的自发性或诱导性戒断综合症的药物以及含有它们的组合物。

公开(公告)号：EP0862581A1

公开(公告)日：1998-09-09

申请号：EP96936680.0

申请日：1996-10-17

申请人： HOECHST MARION ROUSSEL, INC.

发明人： BOROWSKI, Marianne

IPC分类号： C07K1 ,  C07K14

CPC分类号： C07K14/505

摘要： The present invention is directed to a simple and efficient process for the recovery of erythropoietins from biological and culture fluids using Heparin Chromatography. The present invention can be used to obtain research and commercial quantities of erythropoietin.

公开(公告)号：EP0862559A1

公开(公告)日：1998-09-09

申请号：EP96939961.0

申请日：1996-11-21

申请人： HOECHST MARION ROUSSEL

发明人： CLAUSSNER, André ,  GOUBET, François ,  TEUTSCH, Jean-Jacques

IPC分类号： A61K31 ,  A61P13 ,  A61P17 ,  A61P35 ,  A61P43 ,  C07D233 ,  C07D235

CPC分类号： C07D235/02 ,  A61K31/4166 ,  C07D233/76

摘要： Products of formula (I), wherein R1 and R2 are particularly cyano and trifluoromethyl, R3 is particularly alkyl, alkenyl or alkynyl, optionally substituted by one or more of halogen, cyano or hydroxyl, R4 and R5 either are particularly methyl optionally substituted by fluorine or form particularly a cyclohexyl radical, and X and Y are particularly oxygen, as well as salts and isomers thereof, are disclosed.

公开(公告)号：EP0846269A1

公开(公告)日：1998-06-10

申请号：EP96924657.0

申请日：1996-07-23

申请人： HOECHST MARION ROUSSEL, INC.

发明人： GOYAL, Shefali ,  PAUL, Joseph, West ,  RIEDEL, Norbert, G. ,  SAHASRABUDHE, Sudhir, R.

IPC分类号： G01N33

CPC分类号： G01N33/6896 ,  G01N2500/02

摘要： A method of determining the degree of aggregation of the βA4 peptide is disclosed. The method comprises reacting the protein with a suitable binding agent which is capable of binding the βA4 peptide only in its non-aggregated state to form an amount of protein bound binding reagent. The amount of protein bound binding agent is then measured.