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公开(公告)号：EP3438675A1
公开(公告)日：2019-02-06
申请号：EP18187059.3
申请日：2018-08-02
申请人： Shimadzu Corporation
发明人： KAWAKAMI, Daisuke
摘要： To provide a preprocessing apparatus with a function of stirring and sucking a sample in a sample container carried on a conveyor line outside the preprocessing apparatus.
The preprocessing apparatus includes a sampling unit, a unit that stirs a sample before suction, and a stirring operation control unit. The sampling unit includes a sample probe that sucks a sample in the sample container, and is configured to move the sample probe to the sample container set in the sample container setting part and to an external suction location set on a conveyor line located outside the preprocessing apparatus. The unit that stirs a sample before suction includes a stirring probe which stirs a sample in the sample container, and moves the stirring probe at least to the external suction location or a location upstream of the external suction location on the conveyor line. The stirring operation control unit is configured to control operation of the sampling unit and the unit that stirs a sample before suction so that a sample in the sample container is stirred by the stirring probe before the sample is sucked by the sample probe.-
82.发明公开
公开(公告)号：EP3428650A2
公开(公告)日：2019-01-16
申请号：EP18183279.1
申请日：2018-07-12
申请人： Shimadzu Corporation
IPC分类号： G01N33/68
摘要： In the present invention, multiple reaction monitoring (MRM) measurements of at least one peptide selected from the group consisting of 14 peptides as biomarkers of cognitive dysfunction diseases contained in a biological sample are performed using a mass spectrometer capable of MS/MS measurement, and the peptide is quantified based on a result thereof. In this case, for each peptide, an MRM transition which is a combination of a mass-to-charge ratio of a precursor ion and a mass-to-charge ratio of a product ion is stored in advance in a storage unit of the mass spectrometer as a measurement condition of the MRM measurement, and the MRM transition is used when cognitive dysfunction disease biomarkers are detected.
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公开(公告)号：EP3428637A1
公开(公告)日：2019-01-16
申请号：EP16893394.3
申请日：2016-03-07
申请人： Shimadzu Corporation
摘要： A GC/MS measurement under an ionization by an electron ionization method is performed for a target sample (S1). Peaks are detected on a chromatogram based on obtained data, and a mass spectrum corresponding to each peak is compared with a compound database to identify a compound (S2-S4). A compound identified with a low degree of similarity is extracted as the measurement compound. For this compound, a measurement window including the retention time of a peak corresponding to the compound is set, and a control program for performing an ionization by a chemical ionization method only within the measurement window is created (S5-S8). According to this control program, a GC/MS measurement for the target sample is performed, with the device controlled so that a reagent gas is supplied into an ionization chamber and a filament for generating thermions is energized within the measurement window, whereas the supply of the reagent gas is discontinued and the filament is deenergized within time ranges other than the measurement window (S9). Since no reagent-gas ion is generated within the time ranges other than the measurement window, the adhesion of the ions to the inside of the ionization chamber and other locations will be reduced. Accordingly, a stable measurement can be performed for a long period of time.
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公开(公告)号：EP3428636A1
公开(公告)日：2019-01-16
申请号：EP16893399.2
申请日：2016-03-07
申请人： Shimadzu Corporation
发明人： AONO, Akira , SAWAMURA, Isao
摘要： A sample introduction device 100 includes a heating unit 102, an ultraviolet irradiation unit 103, and a sample supply part 106. The heating unit 102 vaporizes a sample 22 by heating externally a container 2 in which the sample 22 is enclosed. The ultraviolet irradiation unit 103 causes ultraviolet rays to pass through the container 2 and irradiates the sample 22 with the ultraviolet rays. The sample supply part 106 supplies the sample vaporized in the container 2 to a gas chromatograph 1 side.
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公开(公告)号：EP3425355A1
公开(公告)日：2019-01-09
申请号：EP18182122.4
申请日：2018-07-06
申请人： Shimadzu Corporation
发明人： Kato, Daijiro , Wakuda, Shinya
摘要： The Fourier transform infrared spectrophotometer includes: a light source 11 for generating infrared light having a wavelength width including an absorption wavelength of a compound to be analyzed; an interferometer including a fixed mirror 15 and a movable mirror 16, for generating interfering light from the infrared light; a detector 25 for generating a voltage with a magnitude corresponding to the intensity of the interfering light, and for outputting a voltage obtained by subtracting, from the aforementioned voltage, a voltage with a predetermined magnitude; a high-pass filter 464 for allowing the passage of frequency components equal to or higher than a predetermined frequency in an output voltage from the detector 25; an amplifier 463 for amplifying an output voltage from the high-pass filter 464 by a predetermined multiplying factor; and an analogue-to-digital converter 27 for converting an output voltage from the amplifier 463 into a digital signal.
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公开(公告)号：EP3422388A2
公开(公告)日：2019-01-02
申请号：EP18179957.8
申请日：2018-06-26
申请人： Shimadzu Corporation
摘要： Lipid-derived ions captured within an ion trap are irradiated with hydrogen radicals to induce the reaction of hydrogen extraction (S1, S2). A precursor-ion isolation process is subsequently performed (S3), and the precursor ion is dissociated by low-energy collision-induced dissociation (S4). The thereby generated product ions are subjected to mass spectrometry to create a product-ion spectrum (S5, S6). Since the dissociation achieved by such a procedure does not cause hydrogen rearrangement, a peak pair having a mass difference of +12 Da characteristic of the unsaturated bond site certainly appears on the product-ion spectrum. By searching for this peak pair, the unsaturated bond site can be located (S7, S8). By such a method, a lipid-structure analysis including the determination of the position of the unsaturated bond site in a lipid can be performed in a stable and accurate manner without requiring derivatization or other cumbersome pretreatments.
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公开(公告)号：EP3413261A1
公开(公告)日：2018-12-12
申请号：EP15910215.1
申请日：2015-12-09
申请人： Shimadzu Corporation
发明人： ONO, Koji
摘要： An analysis data collector (11) stores data acquired with an analytical instrument (2) in a file to which a data ID has been given, and registers the file in a database (14). A log information collector (12) registers, in the database (14), log information which shows various operations on each analytical instrument (2) or client terminal (4), state of the device or the like. For a log related to a file operation, the data ID is additionally saved. After one or more data files are selected, a command to create an audit trail is issued, whereupon an audit trail information extractor (43) collects information corresponding to those data files, such as a data ID, device ID, user ID, and date and time of registration. Subsequently, the audit trail information extractor extracts, from the database (14), each piece of log information which contains the data ID as well as all pieces of log information which contain the device ID and user ID and were obtained within a time range from login to logout including the date and time of registration. An audit trail creator (42) creates an audit trail by organizing the log information in time-series order, and registers it in the database (14).
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公开(公告)号：EP2418481B1
公开(公告)日：2018-11-28
申请号：EP09842921.0
申请日：2009-04-07
申请人： Shimadzu Corporation
发明人： YAMAGUCHI, Shinichi
CPC分类号： H01J49/0036 , G01D7/02 , G06F17/40 , G06F19/00 , G06F19/703 , H01J49/26
摘要： From the data obtained by an LC/MS analysis in which an automatic MS n analysis is performed, all MS 2 spectrum data are collected (S1), and a data matrix is created whose elements are peak intensity data with different precursor ions being arrayed in the horizontal direction and the mass-to-charge ratio of the product ions in the vertical direction (S2). By using the data in this data matrix, the correlation coefficients between two precursor ions are computed to create a correlation coefficient matrix (S3). In the correlation coefficient matrix, the diagonal elements whose value is "1" are all replaced by "0" to create an adjacency matrix (S4). A network analysis is performed for the adjacency matrix to create a network map showing the correlations among different precursor ions (MS 2 spectra) (S5). The network map is displayed on a window of a display unit simultaneously with the result of an MS 1 analysis to provide an analysis operator with information on the compounds contained in a sample or the structure thereof (S6).
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公开(公告)号：EP3404696A1
公开(公告)日：2018-11-21
申请号：EP16884942.0
申请日：2016-01-15
申请人： Shimadzu Corporation
CPC分类号： G01N27/62 , H01J49/401
摘要： A multipole ion guide (30) including a plurality of rod electrodes arranged at an angle to the central axis (C) is placed within a collision cell (13) located in the previous stage of an orthogonal accelerator (16). Radio-frequency voltages with opposite phases are applied to the rod electrodes of the ion guide (30) so that any two rod electrodes neighboring each other in the circumferential direction have opposite phases of the voltage. A depth gradient of the pseudopotential is thereby formed from the entrance end toward the exit end within the space surrounded by the rod electrodes, and ions are accelerated by this gradient. During an ion-accumulating process, a direct voltage having the same polarity as the ions is applied to the exit lens electrode (132) to form a potential barrier for accumulating ions. Among the ions repelled by the potential barrier, ions having smaller m/z return closer to the entrance end. Therefore, when the potential barrier is removed and ions are discharged, ions having smaller m/z are discharged at later points in time than those having larger m/z. Therefore, a wide m/z range of ions can be simultaneously accelerated and ejected by an orthogonal accelerator (16).
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公开(公告)号：EP3404397A1
公开(公告)日：2018-11-21
申请号：EP16884975.0
申请日：2016-06-06
申请人： Shimadzu Corporation
发明人： TAKEUCHI Ippei , FUJIYAMA Yoichi , KUDOH Shinobu , INOUE Koji
摘要： This specimen collection device has a channel through which a specimen can be drawn by capillarity. The channel has two channel sections that extend from the tip side to the base side and are connected at the tip side. One of the channel sections is connected to a base side specimen intake port, and the other terminates at a location prior to reaching the base end. An air hole is provided at this terminating location. The specimen collection device is equipped with an extraction unit for collecting a prescribed amount of the specimen. The extraction unit includes the two channel sections on the tip side of the air hole, and can be severed from the other sections of the device body of the specimen collection device via a severable section.
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