公开(公告)号：EP0800532B1

公开(公告)日：2006-03-08

申请号：EP95943747.6

申请日：1995-12-12

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： RIVIER, Jean E.F.

IPC分类号： C07K14/575 ,  G01N33/50

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C07K14/57509 ,  G01N33/502 ,  G01N33/566 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/74 ,  G01N2333/5751 ,  Y10S514/805 ,  Y10S930/26

摘要： Novel cyclic CRF agonist peptides have the amino acid sequence: (cyclo 30-33)Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-R30-Ala-R32-R33-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 wherein R30 is Glu or Cys; R32 is His or a D-amino acid such as D-His, D-Arg or similar; R33 is Lys, Orn or Cys. The N-terminus may be extended by Ser-Glu-Glu. Lys may be substituted for Arg23, and its side chain connected by a lactam bridge to Glu20 to form a bicyclic peptide. Certain disclosed CRF agonists include: (cyclo 30-33)[Ac-Pro?4, D-Phe12, Nle21,38, D-His32, Glu30, Lys33¿]r/hCRF(4-41), (cyclo 30-33)[Ac-Pro?4, D-Phe12, Nle21,38, D-His32, Glu30, Orn33¿]r/hCRF(4-41), (cyclo 30-33)[Ac-Pro?4, D-Phe12, Nle21,38, Cys30,33, D-His32¿]r/hCRF(4-41), (bicyclo 20-23, 30-33)[Ac-Pro¿4?, D-Phe?12, Nle21,38, Lys23,33, Glu30, D-His32¿]-r/hCRF(4-41), (cyclo 30-33)[Ac-Pro¿4?, D-Phe?12, Nle21,38, CML27, Glu30¿, imBzlD-His?32, Lys33¿]r/hCRF(4-41) and (cyclo 30-33)[Ac-Pro?4, D-Phe12, Nle21,38, Glu30, D-Arg32, Lys33¿]r/hCRF(4-41). Labelled agonists such as (cyclo 30-33)[I?125Tyr0, D-Phe12, Nle21,38, Glu30, D-His32, Lys33¿]r/hCRF and (cyclo 30-33)[I?125D-Tyr3, D-Phe12, Nle21,38, Glu30, D-His32, Lys33¿]r/hCRF(3-41) are useful in screening for more potent agonists.

公开(公告)号：EP0983769A1

公开(公告)日：2000-03-08

申请号：EP98912774.1

申请日：1998-04-13

申请人： Mitsubishi-Tokyo Pharmaceuticals, Inc.

发明人： YAZAKI, Takashi Tokyo Tanabe Company Limited ,  HASHIMOTO, Mitsuo Tokyo Tanabe Company Limited ,  NAKANISHI, Seiki Tokyo Tanabe Company Limited

IPC分类号： A61K47/14

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K38/08 ,  Y10S514/807 ,  Y10S514/808 ,  Y10S930/26

摘要： A permucous composition characterized by comprising Antago-3 or a physiologically acceptable salt thereof and a sucrose/fatty acid ester. The composition can serve as a pharmaceutical preparation which has the high permucous absorbability of physiologically active peptide Antago-3 and is unstimulative and stable for long.

摘要翻译： 一种浸膏组合物，其特征在于含有Antago-3或其生理学上可接受的盐和蔗糖/脂肪酸酯。 该组合物可以用作具有生理活性肽Antago-3的高渗透吸收性并且长期不具有刺激性和稳定性的药物制剂。

公开(公告)号：EP0894002A1

公开(公告)日：1999-02-03

申请号：EP97914964.0

申请日：1997-03-11

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： LAMBRIS, John, D. ,  SAHU, Arvind K.

IPC分类号： A61K38 ,  A61K31 ,  A61P29 ,  C07K7 ,  C07K14

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K7/64 ,  C07K14/472 ,  Y10S930/26

摘要： Peptides capable of inhibiting complement activation are provided. Methods of inhibiting complement activation and complement-mediated tissue injury using these peptides are also provided. In addition, a method of producing compositions capable of inhibiting complement activation using these peptides is provided, along with the peptide analogs and peptidomimetics produced by the method.

公开(公告)号：EP0448126B1

公开(公告)日：1998-12-30

申请号：EP91105948.3

申请日：1985-02-28

申请人： New York Blood Center, Inc. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Neurath, Alexander Robert ,  Kent, Stephen B.H.

IPC分类号： A61K39/385 ,  A61K39/39 ,  A61K47/48

CPC分类号： C07K14/005 ,  A61K9/1271 ,  A61K39/00 ,  A61K47/58 ,  A61K47/645 ,  A61K47/6911 ,  C07K16/082 ,  C12N2730/10122 ,  G01N33/5764 ,  Y02A50/466 ,  Y10S930/221 ,  Y10S930/222 ,  Y10S930/223 ,  Y10S930/26 ,  Y10S930/27

摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

公开(公告)号：EP0777681A2

公开(公告)日：1997-06-11

申请号：EP95931586.0

申请日：1995-08-25

申请人： CYTEL CORPORATION

发明人： ARRHENIUS, Thomas, S. ,  ELICES, Mariano, J. ,  TEMPCZYK, Anna ,  ZHENG, Zhong-Li

IPC分类号： C07K5 ,  C07K14 ,  A61K38

CPC分类号： C07K5/1024 ,  A61K38/00 ,  C07K5/0808 ,  C07K5/1013 ,  C07K5/126 ,  C07K14/78 ,  Y10S930/26 ,  Y10S930/27

摘要： The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated cyclic peptide and processes for treating immunoinflammatory conditions using a binding-inhibitory cyclic peptide are also disclosed.

公开(公告)号：EP0695309A1

公开(公告)日：1996-02-07

申请号：EP94915332.0

申请日：1994-02-09

申请人： NORTHWESTERN UNIVERSITY

发明人： FLOURET, George ,  WILSON, Laird

IPC分类号： A61K38 ,  A61P5 ,  A61P13 ,  A61P15 ,  C07K7

CPC分类号： C07K7/16 ,  A61K38/00 ,  Y10S930/26

摘要： The oxytocin antagonist represented by formula (I) wherein (S-Pmp IS β,β-(3-thiapentamethylene)-β-mercaptopropionic acid, D-Trp is the D form of tryptophan, and Ile, Gln, Asn, Pen (Pen = penicillamine), Pro, and Arg are the L forms of isoleucine, glutamine, asparagine, proline and arginine, respectively. This compound can be administered to pregnant women to arrest premature labor while avoiding unwanted side effects due to antagonism of the antidiuretic hormone, vasopressin.

公开(公告)号：EP0171887B1

公开(公告)日：1993-03-10

申请号：EP85304163.0

申请日：1985-06-12

申请人： ELI LILLY AND COMPANY

发明人： Frank, Bruce Hill ,  Pekar, Allen Howard

IPC分类号： C12P21/02 ,  C07K7/10 ,  A61K37/02

CPC分类号： C07K14/62 ,  A61K38/00 ,  Y10S930/26

公开(公告)号：EP0267179B1

公开(公告)日：1993-02-17

申请号：EP87890244.4

申请日：1987-11-04

申请人： Kabi Pharmacia GmbH

发明人： Naderer,Dr. Rainer ,  Langer, Dr. Klaus ,  Buxbaum, Dr. Lothar

IPC分类号： C07K5/06 ,  A23L1/305

CPC分类号： C07K5/0806 ,  C07K5/06026 ,  C07K5/06078 ,  Y10S930/26

公开(公告)号：EP0515400A1

公开(公告)日：1992-12-02

申请号：EP91902940.0

申请日：1991-01-16

申请人： RADEX-HERAKLITH INDUSTRIEBETEILIGUNGS AKTIENGESELLSCHAFT

发明人： MÖRTL, Günter ,  Siegl, Walter ,  LOOP, Peter

IPC分类号： C04B35

CPC分类号： C04B35/63472 ,  A61K38/00 ,  C04B35/06 ,  C04B35/6316 ,  C04B35/66 ,  C04B2111/00482 ,  C04B2111/00612 ,  C04B2235/3205 ,  C04B2235/3241 ,  C04B2235/3244 ,  C07K14/6555 ,  Y10S930/16 ,  Y10S930/26

摘要： L'invention concerne une matière pour l'enduction d'un garnissage d'un récipient de fusion métallurgique, à base d'oxydes réfractaires tels que magnésie frittée, magnésie-chromite, dolomite frittée, minerai de chrome et/ou dioxyde de zirconium.

公开(公告)号：EP0188400B1

公开(公告)日：1992-07-08

申请号：EP86810007.4

申请日：1986-01-10

申请人： CIBA-GEIGY AG

发明人： Jansz, Hendrik Simons, Prof. Dr. ,  Lips, Cornelis Josephus Maria, Dr. ,  Steenbergh, Paul Herman, Dr. ,  Rink, Hans ,  Sieber, Peter

IPC分类号： C07K7/00 ,  A61K37/02 ,  C12N15/00 ,  C12P21/02

CPC分类号： C07K14/57527 ,  A61K38/00 ,  Y10S930/26